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Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota.

Abstract：

:Clostridium difficile is the leading cause of nosocomial diarrhea and colitis in the industrialized world. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug-resistant C. difficile, which secrete up to three different protein toxins that are responsible for the gastrointestinal sequelae. Oral agents that inhibit the damage induced by toxins, without altering the gut microbiota, are urgently needed to prevent primary disease and break the cycle of antibiotic-induced disease recurrence. Here, we show that the anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for entry into colonocytes by each toxin. In mice infected with an epidemic strain of C. difficile, expressing all three toxins, niclosamide reduced both primary disease and recurrence, without disrupting the diversity or composition of the gut microbiota. Given its excellent safety profile, niclosamide may address an important unmet need in preventing C. difficile primary and recurrent diseases.

journal_name

Nat Commun

journal_title

Nature communications

authors

Tam J,Hamza T,Ma B,Chen K,Beilhartz GL,Ravel J,Feng H,Melnyk RA

doi

10.1038/s41467-018-07705-w

subject

Has Abstract

pub_date

2018-12-07 00:00:00

pages

5233

issue

1

issn

2041-1723

pii

10.1038/s41467-018-07705-w

journal_volume

9

pub_type

杂志文章

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