Abstract:
:Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+, an algorithm that improves on the previous approaches for identifying peptidic natural products, and extends them for identification of polyketides, terpenes, benzenoids, alkaloids, flavonoids, and other classes of natural products. We show that DEREPLICATOR+ can search all spectra in the recently launched Global Natural Products Social molecular network and identify an order of magnitude more natural products than previous dereplication efforts. We further demonstrate that DEREPLICATOR+ enables cross-validation of genome-mining and peptidogenomics/glycogenomics results.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Mohimani H,Gurevich A,Shlemov A,Mikheenko A,Korobeynikov A,Cao L,Shcherbin E,Nothias LF,Dorrestein PC,Pevzner PAdoi
10.1038/s41467-018-06082-8subject
Has Abstractpub_date
2018-10-02 00:00:00pages
4035issue
1issn
2041-1723pii
10.1038/s41467-018-06082-8journal_volume
9pub_type
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