Microbial metabolite sensor GPR43 controls severity of experimental GVHD.

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:Currently, solar-thermal energy storage within phase-change materials relies on adding high thermal-conductivity fillers to improve the thermal-diffusion-based charging rate, which often leads to limited enhancement of charging speed and sacrificed energy storage capacity. Here we report the exploration of a magnetica...

journal_title：Nature communications

authors： Wang Z,Tong Z,Ye Q,Hu H,Nie X,Yan C,Shang W,Song C,Wu J,Wang J,Bao H,Tao P,Deng T

更新日期：2017-11-14 00:00:00

abstract：:Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they...

journal_title：Nature communications

authors： Zheng X,Tizzano M,Redding K,He J,Peng X,Jiang P,Xu X,Zhou X,Margolskee RF

更新日期：2019-10-03 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...

journal_title：Nature communications

authors： Aghion S,Ahlén O,Amsler C,Ariga A,Ariga T,Belov AS,Berggren K,Bonomi G,Bräunig P,Bremer J,Brusa RS,Cabaret L,Canali C,Caravita R,Castelli F,Cerchiari G,Cialdi S,Comparat D,Consolati G,Derking H,Di Domizio S,Di N

更新日期：2014-07-28 00:00:00

abstract：:Controlling the domain size and degree of crystallization in organic films is highly important for electronic applications such as organic photovoltaics, but suitable nanoscale mapping is very difficult. Here we apply infrared-spectroscopic nano-imaging to directly determine the local crystallinity of organic thin fil...

journal_title：Nature communications

authors： Westermeier C,Cernescu A,Amarie S,Liewald C,Keilmann F,Nickel B

更新日期：2014-06-11 00:00:00

abstract：:Developing single-site catalysts featuring maximum atom utilization efficiency is urgently desired to improve oxidation-reduction efficiency and cycling capability of lithium-oxygen batteries. Here, we report a green method to synthesize isolated cobalt atoms embedded ultrathin nitrogen-rich carbon as a dual-catalyst ...

journal_title：Nature communications

authors： Wang P,Ren Y,Wang R,Zhang P,Ding M,Li C,Zhao D,Qian Z,Zhang Z,Zhang L,Yin L

更新日期：2020-03-27 00:00:00

abstract：:Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...

journal_title：Nature communications

authors： Umeshappa CS,Singha S,Blanco J,Shao K,Nanjundappa RH,Yamanouchi J,Parés A,Serra P,Yang Y,Santamaria P

更新日期：2019-05-14 00:00:00

abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

journal_title：Nature communications

authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

更新日期：2013-01-01 00:00:00

abstract：:Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...

journal_title：Nature communications

authors： Nerli S,De Paula VS,McShan AC,Sgourakis NG

更新日期：2021-01-29 00:00:00

abstract：:Genomic evidence is increasingly underpinning that hybridization between taxa is commonplace, challenging our views on the mechanisms that maintain their boundaries. Here, we focus on seven catadromous eel species (genus Anguilla) and use genome-wide sequence data from more than 450 individuals sampled across the trop...

journal_title：Nature communications

authors： Barth JMI,Gubili C,Matschiner M,Tørresen OK,Watanabe S,Egger B,Han YS,Feunteun E,Sommaruga R,Jehle R,Schabetsberger R

更新日期：2020-03-18 00:00:00

abstract：:In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

journal_title：Nature communications

authors： Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

更新日期：2018-08-20 00:00:00

abstract：:The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...

journal_title：Nature communications

authors： Santodonato LJ,Zhang Y,Feygenson M,Parish CM,Gao MC,Weber RJ,Neuefeind JC,Tang Z,Liaw PK

更新日期：2015-01-20 00:00:00

abstract：:During plant radial growth typically seen in trees, procambial and cambial cells act as meristematic cells in the vascular system to self-proliferate and differentiate into xylem cells. These two processes are regulated by a signalling pathway composed of a peptide ligand and its receptor; tracheary element differenti...

journal_title：Nature communications

authors： Kondo Y,Ito T,Nakagami H,Hirakawa Y,Saito M,Tamaki T,Shirasu K,Fukuda H

更新日期：2014-03-24 00:00:00

abstract：:The reported progressive change of vegetation activity along elevational gradients has important aesthetic and conservation values. With climate change, cooler locations are suggested to warm faster than warmer ones, raising concerns of a more homogenized landscape along the elevation. Here, we use global satellite da...

journal_title：Nature communications

authors： Gao M,Piao S,Chen A,Yang H,Liu Q,Fu YH,Janssens IA

更新日期：2019-07-05 00:00:00

abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

journal_title：Nature communications

authors： Handley C,Mathew S

更新日期：2020-02-04 00:00:00

abstract：:MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...

journal_title：Nature communications

authors： Meng L,Liu C,Lü J,Zhao Q,Deng S,Wang G,Qiao J,Zhang C,Zhen L,Lu Y,Li W,Zhang Y,Pestell RG,Fan H,Chen YH,Liu Z,Yu Z

更新日期：2017-01-03 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P re...

journal_title：Nature communications

authors： Nussbaum C,Bannenberg S,Keul P,Gräler MH,Gonçalves-de-Albuquerque CF,Korhonen H,von Wnuck Lipinski K,Heusch G,de Castro Faria Neto HC,Rohwedder I,Göthert JR,Prasad VP,Haufe G,Lange-Sperandio B,Offermanns S,Sperandio M,Lev

更新日期：2015-04-02 00:00:00

abstract：:Rabies virus (RABV) causes fatal encephalitis in more than 59,000 people yearly. Upon the bite of an infected animal, the development of clinical disease can be prevented with post-exposure prophylaxis (PEP), which includes the administration of Rabies immunoglobulin (RIG). However, the high cost and limited availabil...

journal_title：Nature communications

authors： Hellert J,Buchrieser J,Larrous F,Minola A,de Melo GD,Soriaga L,England P,Haouz A,Telenti A,Schwartz O,Corti D,Bourhy H,Rey FA

更新日期：2020-01-30 00:00:00

abstract：:Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. He...

journal_title：Nature communications

authors： Sultana N,Zhang L,Yan J,Chen J,Cai W,Razzaque S,Jeong D,Sheng W,Bu L,Xu M,Huang GY,Hajjar RJ,Zhou B,Moon A,Cai CL

更新日期：2015-10-30 00:00:00

abstract：:The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such inter...

journal_title：Nature communications

authors： Ait-Bouziad N,Lv G,Mahul-Mellier AL,Xiao S,Zorludemir G,Eliezer D,Walz T,Lashuel HA

更新日期：2017-11-22 00:00:00

abstract：:The Dead Sea is one of the most hypersaline habitats on Earth. The fungus Eurotium rubrum (Eurotiomycetes) is among the few species able to survive there. Here we highlight its adaptive strategies, based on genome analysis and transcriptome profiling. The 26.2 Mb genome of E. rubrum shows, for example, gains in gene f...

journal_title：Nature communications

authors： Kis-Papo T,Weig AR,Riley R,Peršoh D,Salamov A,Sun H,Lipzen A,Wasser SP,Rambold G,Grigoriev IV,Nevo E

更新日期：2014-05-09 00:00:00

abstract：:The outcome of adult cochlear implantation is predicted positively by the involvement of visual cortex in speech processing, and negatively by the cross-modal recruitment of the right temporal cortex during and after deafness. How these two neurofunctional predictors concur to modulate cochlear implant (CI) performanc...

journal_title：Nature communications

authors： Lazard DS,Giraud AL

更新日期：2017-03-28 00:00:00

abstract：:Bacteriophage Q protein engages σ-dependent paused RNA polymerase (RNAP) by binding to a DNA site embedded in late gene promoter and renders RNAP resistant to termination signals. Here, we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact Q-engaged arrested complex. The structure revea...

journal_title：Nature communications

authors： Shi J,Gao X,Tian T,Yu Z,Gao B,Wen A,You L,Chang S,Zhang X,Zhang Y,Feng Y

更新日期：2019-07-02 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00

abstract：:Various quantum applications can be reduced to estimating expectation values, which are inevitably deviated by operational and environmental errors. Although errors can be tackled by quantum error correction, the overheads are far from being affordable for near-term technologies. To alleviate the detrimental effects o...

journal_title：Nature communications

authors： Zhang S,Lu Y,Zhang K,Chen W,Li Y,Zhang JN,Kim K

更新日期：2020-01-30 00:00:00

abstract：:Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populations retaining or l...

journal_title：Nature communications

authors： Muzumdar MD,Dorans KJ,Chung KM,Robbins R,Tammela T,Gocheva V,Li CM,Jacks T

更新日期：2016-09-02 00:00:00

abstract：:Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging...

journal_title：Nature communications

authors： Ravagli E,Mastitskaya S,Thompson N,Iacoviello F,Shearing PR,Perkins J,Gourine AV,Aristovich K,Holder D

更新日期：2020-12-07 00:00:00

abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

journal_title：Nature communications

authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

更新日期：2016-09-23 00:00:00

abstract：:The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...

journal_title：Nature communications

authors： Boers N

更新日期：2018-07-02 00:00:00