Abstract：
:Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characterize the multimodal architectural properties and interplay of the Alba1 and Alba2 proteins using single-molecule imaging and manipulation techniques. We demonstrate that the two paralogues can bridge and rigidify DNA and that the interplay between the two proteins influences the balance between these effects. Our data yield a structural model that explains the multimodal behaviour of Alba proteins and its impact on genome folding.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Laurens N,Driessen RP,Heller I,Vorselen D,Noom MC,Hol FJ,White MF,Dame RT,Wuite GJdoi
10.1038/ncomms2330subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1328issn
2041-1723pii
ncomms2330journal_volume
3pub_type
杂志文章abstract：:Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9745
更新日期：2015-10-26 00:00:00
abstract：:UV vision is prevalent, but we know little about its utility in common general tasks, as in resolving habitat structure. Here we visualize vegetated habitats using a multispectral camera with channels mimicking bird photoreceptor sensitivities across the UV-visible spectrum. We find that the contrast between upper and...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08142-5
更新日期：2019-01-22 00:00:00
abstract：:Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we d...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8947
更新日期：2015-08-06 00:00:00
abstract：:Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2893
更新日期：2013-01-01 00:00:00
abstract：:An essential issue in the development of materials presenting an accurately functionalized surface is to achieve control of layer structuring. Whereas the very popular method based on the spontaneous adsorption of alkanethiols on metal faces stability problems, the reductive electrografting of aryldiazonium salts yiel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2121
更新日期：2012-01-01 00:00:00
abstract：:Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) nanostructures, designed to be precisely motion-controlled. Although two-dimensional (2D) imaging of DNA nanoma...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03018-0
更新日期：2018-02-09 00:00:00
abstract：:Quantum point contacts exhibit mysterious conductance anomalies in addition to well-known conductance plateaus at multiples of 2e(2)/h. These 0.7 and zero-bias anomalies have been intensively studied, but their microscopic origin in terms of many-body effects is still highly debated. Here we use the charged tip of a s...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5290
更新日期：2014-06-30 00:00:00
abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18119-y
更新日期：2020-08-28 00:00:00
abstract：:In high magnetic fields, two-dimensional electron systems can form a number of phases in which interelectron repulsion plays the central role, since the kinetic energy is frozen out by Landau quantization. These phases include the well-known liquids of the fractional quantum Hall effect, as well as solid phases with b...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5154
更新日期：2014-06-20 00:00:00
abstract：:Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14505
更新日期：2017-02-21 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms15533. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms16129
更新日期：2017-07-04 00:00:00
abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07339-y
更新日期：2018-11-29 00:00:00
abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9143
更新日期：2015-09-03 00:00:00
abstract：:Stress is a major cause of poor health and mortality in humans and other social mammals. Close social bonds buffer stress, however much of the underlying physiological mechanism remains unknown. Here, we test two key hypotheses: bond partner effects occur only during stress (social buffering) or generally throughout d...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13361
更新日期：2016-11-01 00:00:00
abstract：:A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de no...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01082-6
更新日期：2017-10-19 00:00:00
abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2580
更新日期：2013-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-10951-1
更新日期：2019-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-11801-w
更新日期：2019-08-19 00:00:00
abstract：:Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive ceph...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16151-6
更新日期：2020-06-02 00:00:00
abstract：:Any experienced event may be encoded and retained in detail as part of our episodic memory, and may also refer and contribute to our generalized knowledge stored in semantic memory. The beginnings of this declarative memory formation are only poorly understood. Even less is known about the interrelation between episod...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14850-8
更新日期：2020-03-10 00:00:00
abstract：:TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17097-5
更新日期：2020-07-03 00:00:00
abstract：:High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle in the Rocky Mountains, USA. Although multiple genes are likely involved in the genesis of HAPH, to date no major gene variant has been identified. Using whole-exome sequencing, we report the high association of ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7863
更新日期：2015-04-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-11151-7
更新日期：2019-07-22 00:00:00
abstract：:In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9557
更新日期：2015-10-15 00:00:00
abstract：:How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19936-x
更新日期：2020-12-02 00:00:00
abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15588-z
更新日期：2020-04-08 00:00:00
abstract：:HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fu...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1681
更新日期：2012-02-21 00:00:00
abstract：:Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00166-7
更新日期：2017-08-04 00:00:00
abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15761
更新日期：2017-06-08 00:00:00
abstract：:Selection rules are of vital importance in determining the basic optical properties of atoms, molecules and semiconductors. They provide general insights into the symmetry of the system and the nature of relevant electronic states. A two-dimensional electron gas in a magnetic field is a model system where optical tran...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16844-y
更新日期：2020-06-10 00:00:00
