Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.

abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

journal_title：Nature communications

authors： Ryu KS,Yang SH,Thomas L,Parkin SS

更新日期：2014-05-23 00:00:00

abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...

journal_title：Nature communications

authors： Krishnan ML,Van Steenwinckel J,Schang AL,Yan J,Arnadottir J,Le Charpentier T,Csaba Z,Dournaud P,Cipriani S,Auvynet C,Titomanlio L,Pansiot J,Ball G,Boardman JP,Walley AJ,Saxena A,Mirza G,Fleiss B,Edwards AD,Petretto

更新日期：2017-09-05 00:00:00

abstract：:In the human hematopoietic system, rare self-renewing multipotent long-term hematopoietic stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the rational target for clinical regenerative therapies. However, the heterogeneity in the hematopoietic stem cell compartment and var...

journal_title：Nature communications

authors： Wagenblast E,Azkanaz M,Smith SA,Shakib L,McLeod JL,Krivdova G,Araújo J,Shultz LD,Gan OI,Dick JE,Lechman ER

更新日期：2019-10-18 00:00:00

abstract：:Although research on human-mediated exchanges of species has substantially intensified during the last centuries, we know surprisingly little about temporal dynamics of alien species accumulations across regions and taxa. Using a novel database of 45,813 first records of 16,926 established alien species, we show that ...

journal_title：Nature communications

authors： Seebens H,Blackburn TM,Dyer EE,Genovesi P,Hulme PE,Jeschke JM,Pagad S,Pyšek P,Winter M,Arianoutsou M,Bacher S,Blasius B,Brundu G,Capinha C,Celesti-Grapow L,Dawson W,Dullinger S,Fuentes N,Jäger H,Kartesz J,Kenis M

更新日期：2017-02-15 00:00:00

abstract：:Monolayer molybdenum disulfide (MoS2) has attracted tremendous attention due to its promising applications in high-performance field-effect transistors, phototransistors, spintronic devices and nonlinear optics. The enhanced photoluminescence effect in monolayer MoS2 was discovered and, as a strong tool, was employed ...

journal_title：Nature communications

authors： Liu Z,Amani M,Najmaei S,Xu Q,Zou X,Zhou W,Yu T,Qiu C,Birdwell AG,Crowne FJ,Vajtai R,Yakobson BI,Xia Z,Dubey M,Ajayan PM,Lou J

更新日期：2014-11-18 00:00:00

abstract：:Winter Eurasian cooling after the mid-1990s has been verified by numerous studies, although in recent decades, the mid-latitudes of the Northern Hemisphere have been rapidly warming globally. Because the cooling is not uniform at different spatial and temporal scales, over time, this change may not truly reflect the n...

journal_title：Nature communications

authors： Li B,Li Y,Chen Y,Zhang B,Shi X

更新日期：2020-10-15 00:00:00

abstract：:Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require N...

journal_title：Nature communications

authors： dos Santos G,Rogel MR,Baker MA,Troken JR,Urich D,Morales-Nebreda L,Sennello JA,Kutuzov MA,Sitikov A,Davis JM,Lam AP,Cheresh P,Kamp D,Shumaker DK,Budinger GR,Ridge KM

更新日期：2015-03-12 00:00:00

abstract：:How rapidly natural selection sorts genome-wide standing genetic variation during adaptation remains largely unstudied experimentally. Here, we present a genomic release-recapture experiment using paired threespine stickleback fish populations adapted to selectively different lake and stream habitats. First, we use po...

journal_title：Nature communications

authors： Laurentino TG,Moser D,Roesti M,Ammann M,Frey A,Ronco F,Kueng B,Berner D

更新日期：2020-04-21 00:00:00

abstract：:Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride a...

journal_title：Nature communications

authors： Spalding KL,Bernard S,Näslund E,Salehpour M,Possnert G,Appelsved L,Fu KY,Alkass K,Druid H,Thorell A,Rydén M,Arner P

更新日期：2017-05-23 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (...

journal_title：Nature communications

authors： Blomme A,Ford CA,Mui E,Patel R,Ntala C,Jamieson LE,Planque M,McGregor GH,Peixoto P,Hervouet E,Nixon C,Salji M,Gaughan L,Markert E,Repiscak P,Sumpton D,Blanco GR,Lilla S,Kamphorst JJ,Graham D,Faulds K,MacKay GM,

更新日期：2020-05-19 00:00:00

abstract：:CRISPR-Cas9 has led to great advances in gene editing for a broad spectrum of applications. To further the utility of Cas9 there have been efforts to achieve temporal control over its nuclease activity. While different approaches have focused on regulation of CRISPR interference or editing in mammalian cells, none of ...

journal_title：Nature communications

authors： Iwasaki RS,Ozdilek BA,Garst AD,Choudhury A,Batey RT

更新日期：2020-03-13 00:00:00

abstract：:Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs....

journal_title：Nature communications

authors： Ishihara H,Sugimoto K,Tarr PT,Temman H,Kadokura S,Inui Y,Sakamoto T,Sasaki T,Aida M,Suzuki T,Inagaki S,Morohashi K,Seki M,Kakutani T,Meyerowitz EM,Matsunaga S

更新日期：2019-04-16 00:00:00

abstract：:The burial of terrestrial organic carbon (terrOC) in marine sediments contributes to the regulation of atmospheric CO2 on geological timescales and may mitigate positive feedback to present-day climate warming. However, the fate of terrOC in marine settings is debated, with uncertainties regarding its degradation duri...

journal_title：Nature communications

authors： Bröder L,Tesi T,Andersson A,Semiletov I,Gustafsson Ö

更新日期：2018-02-23 00:00:00

abstract：:Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid ce...

journal_title：Nature communications

authors： Denninger P,Bleckmann A,Lausser A,Vogler F,Ott T,Ehrhardt DW,Frommer WB,Sprunck S,Dresselhaus T,Grossmann G

更新日期：2014-08-22 00:00:00

abstract：:The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...

journal_title：Nature communications

authors： Jacobse PH,Kimouche A,Gebraad T,Ervasti MM,Thijssen JM,Liljeroth P,Swart I

更新日期：2017-07-25 00:00:00

abstract：:Selection rules are of vital importance in determining the basic optical properties of atoms, molecules and semiconductors. They provide general insights into the symmetry of the system and the nature of relevant electronic states. A two-dimensional electron gas in a magnetic field is a model system where optical tran...

journal_title：Nature communications

authors： Ju L,Wang L,Li X,Moon S,Ozerov M,Lu Z,Taniguchi T,Watanabe K,Mueller E,Zhang F,Smirnov D,Rana F,McEuen PL

更新日期：2020-06-10 00:00:00

abstract：:Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation module from Pseudomonas syringae. The device comprises two co...

journal_title：Nature communications

authors： Wang B,Kitney RI,Joly N,Buck M

更新日期：2011-10-18 00:00:00

abstract：:In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow...

journal_title：Nature communications

authors： Hornbach MJ,DeShon HR,Ellsworth WL,Stump BW,Hayward C,Frohlich C,Oldham HR,Olson JE,Magnani MB,Brokaw C,Luetgert JH

更新日期：2015-04-21 00:00:00

abstract：:Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

journal_title：Nature communications

authors： Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

更新日期：2020-02-11 00:00:00

abstract：:Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma (HCC) cells. Speci...

journal_title：Nature communications

authors： Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G

更新日期：2019-12-17 00:00:00

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase at a transitional st...

journal_title：Nature communications

authors： Kii I,Sumida Y,Goto T,Sonamoto R,Okuno Y,Yoshida S,Kato-Sumida T,Koike Y,Abe M,Nonaka Y,Ikura T,Ito N,Shibuya H,Hosoya T,Hagiwara M

更新日期：2016-04-22 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00

abstract：:Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...

journal_title：Nature communications

authors： Tagliacozzo L,Celi A,Orland P,Mitchell MW,Lewenstein M

更新日期：2013-01-01 00:00:00

abstract：:Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...

journal_title：Nature communications

authors： Kernstock S,Davydova E,Jakobsson M,Moen A,Pettersen S,Mælandsmo GM,Egge-Jacobsen W,Falnes PØ

更新日期：2012-01-01 00:00:00

abstract：:Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa,...

journal_title：Nature communications

authors： Pernet O,Schneider BS,Beaty SM,LeBreton M,Yun TE,Park A,Zachariah TT,Bowden TA,Hitchens P,Ramirez CM,Daszak P,Mazet J,Freiberg AN,Wolfe ND,Lee B

更新日期：2014-11-18 00:00:00

abstract：:Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...

journal_title：Nature communications

authors： Sun Y,Ma K,Kao T,Spoth KA,Sai H,Zhang D,Kourkoutis LF,Elser V,Wiesner U

更新日期：2017-08-15 00:00:00

abstract：:Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...

journal_title：Nature communications

authors： Mortensen NA,Raza S,Wubs M,Søndergaard T,Bozhevolnyi SI

更新日期：2014-05-02 00:00:00

abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

journal_title：Nature communications

authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

更新日期：2019-11-20 00:00:00