Abstract:
:Transition metal-catalyzed C-H activation and radical reactions are two versatile strategies to construct diverse organic skeletons. Here we show the construction of a class of flavylium fluorophores via the merge of radical chemistry and C-H activation starting from (hetero)aryl ketones and alkynes. This protocol is not only applicable to aryl ketones but also to heteroaryl ketones such as thiophene, benzothiophene and benzofuran, thus leading to structural diversity. Mechanism studies, including control experiments, intermediate separation, radical trapping, EPR and ESI-HRMS experiments, demonstrate that the key step lies in the addition of the acyl radical generated by the copper-catalyzed C-C bond cleavage of aryl ketone to the rhodacycle formed via the C-H activation of aryl ketone. The flavylium fluorophores feature butterfly symmetrical configuration, nearly planar skeleton and delocalized positive charge, and exhibit intriguing photophysical properties, such as tunable absorption and emission wavelengths and high quantum yields.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yin J,Zhang Y,Li J,Zhu L,Lan Y,You Jdoi
10.1038/s41467-019-13611-6subject
Has Abstractpub_date
2019-12-11 00:00:00pages
5664issue
1issn
2041-1723pii
10.1038/s41467-019-13611-6journal_volume
10pub_type
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