Field-programmable silicon temporal cloak.

abstract：:Graphene nanoribbons (GNRs)-narrow stripes of graphene-have emerged as promising building blocks for nanoelectronic devices. Recent advances in bottom-up synthesis have allowed production of atomically well-defined armchair GNRs with different widths and doping. While all experimentally studied GNRs have exhibited wid...

journal_title：Nature communications

authors： Kimouche A,Ervasti MM,Drost R,Halonen S,Harju A,Joensuu PM,Sainio J,Liljeroth P

更新日期：2015-12-14 00:00:00

abstract：:Prokaryotes and eukaryotes alike endogenously generate the gaseous molecule hydrogen sulfide (H2S). Bacterial H2S acts as a cytoprotectant against antibiotics-induced stress and promotes redox homeostasis. In E. coli, endogenous H2S production is primarily dependent on 3-mercaptopyruvate sulfurtransferase (3MST), enco...

journal_title：Nature communications

authors： Luhachack L,Rasouly A,Shamovsky I,Nudler E

更新日期：2019-06-28 00:00:00

abstract：:The ability to link soil microbial diversity to soil processes requires technologies that differentiate active microbes from extracellular DNA and dormant cells. Here, we use BONCAT (bioorthogonal non-canonical amino acid tagging) to measure translationally active cells in soils. We compare the active population of tw...

journal_title：Nature communications

authors： Couradeau E,Sasse J,Goudeau D,Nath N,Hazen TC,Bowen BP,Chakraborty R,Malmstrom RR,Northen TR

更新日期：2019-06-24 00:00:00

abstract：:Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of femtosecond duration from an X-ray free-electron laser. Due to the very low background scattering from the graphene support and mutual alignment of filaments, diff...

journal_title：Nature communications

authors： Seuring C,Ayyer K,Filippaki E,Barthelmess M,Longchamp JN,Ringler P,Pardini T,Wojtas DH,Coleman MA,Dörner K,Fuglerud S,Hammarin G,Habenstein B,Langkilde AE,Loquet A,Meents A,Riek R,Stahlberg H,Boutet S,Hunter MS,Ko

更新日期：2018-05-09 00:00:00

abstract：:Forests impact regional hydrology and climate directly by regulating water and heat fluxes. Indirect effects through cloud formation and precipitation can be important in facilitating continental-scale moisture recycling but are poorly understood at regional scales. In particular, the impact of temperate forest on clo...

journal_title：Nature communications

authors： Teuling AJ,Taylor CM,Meirink JF,Melsen LA,Miralles DG,van Heerwaarden CC,Vautard R,Stegehuis AI,Nabuurs GJ,de Arellano JV

更新日期：2017-01-11 00:00:00

abstract：:Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In th...

journal_title：Nature communications

authors： Satoh K,Ozawa S,Mizutani M,Nagai K,Kamigaito M

更新日期：2010-04-12 00:00:00

abstract：:The physical nature of the bacterial chromosome has important implications for its function. Using high-resolution dynamic tracking, we observe the existence of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics. This suggests that these movements are either driven by an activ...

journal_title：Nature communications

authors： Javer A,Kuwada NJ,Long Z,Benza VG,Dorfman KD,Wiggins PA,Cicuta P,Lagomarsino MC

更新日期：2014-05-30 00:00:00

abstract：:When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, a...

journal_title：Nature communications

authors： Bein O,Duncan K,Davachi L

更新日期：2020-07-10 00:00:00

abstract：:Interactions between a protein and a ligand are essential to all biological processes. Binding and dissociation are the two fundamental steps of ligand-protein interactions, and determine the binding affinity. Intrinsic conformational dynamics of proteins have been suggested to play crucial roles in ligand binding and...

journal_title：Nature communications

authors： Seo MH,Park J,Kim E,Hohng S,Kim HS

更新日期：2014-04-24 00:00:00

abstract：:The exocyst is an essential component of the secretory pathway required for delivery of basolateral proteins to the plasma membranes of epithelial cells. Delivery occurs adjacent to tight junctions (TJ), suggesting that it recognizes a receptor at this location. However, no such receptor has been identified. The Par3 ...

journal_title：Nature communications

authors： Ahmed SM,Macara IG

更新日期：2017-03-30 00:00:00

abstract：:Metal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemica...

journal_title：Nature communications

authors： Wei TH,Wu SH,Huang YD,Lo WS,Williams BP,Chen SY,Yang HC,Hsu YS,Lin ZY,Chen XH,Kuo PE,Chou LY,Tsung CK,Shieh FK

更新日期：2019-11-01 00:00:00

abstract：:Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...

journal_title：Nature communications

authors： Järvå M,Lay FT,Phan TK,Humble C,Poon IKH,Bleackley MR,Anderson MA,Hulett MD,Kvansakul M

更新日期：2018-05-17 00:00:00

abstract：:Age, as a threshold of floral competence acquisition, prevents precocious flowering when there is insufficient biomass, and ensures flowering independent of environmental conditions; however, the underlying regulatory mechanisms are largely unknown. In this study, silencing the expression of a nuclear factor gene, CmN...

journal_title：Nature communications

authors： Wei Q,Ma C,Xu Y,Wang T,Chen Y,Lü J,Zhang L,Jiang CZ,Hong B,Gao J

更新日期：2017-10-10 00:00:00

abstract：:The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa. However, the crosstalk between these two signaling pathways remains unclear. Here we show tha...

journal_title：Nature communications

authors： Wang F,He Q,Yin J,Xu S,Hu W,Gu L

更新日期：2018-07-02 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We report that suppleme...

journal_title：Nature communications

authors： Tan HWS,Sim AYL,Long YC

更新日期：2017-08-24 00:00:00

abstract：:The Fanconi anaemia (FA) pathway is important for the repair of DNA interstrand crosslinks (ICL). The FANCD2-FANCI complex is central to the pathway, and localizes to ICLs dependent on its monoubiquitination. It has remained elusive whether the complex is recruited before or after the critical monoubiquitination. Here...

journal_title：Nature communications

authors： Liang CC,Li Z,Lopez-Martinez D,Nicholson WV,Vénien-Bryan C,Cohn MA

更新日期：2016-07-13 00:00:00

abstract：:Three-dimensional (3D) assemblies based on carbon nanomaterials still lag behind their individual one-dimensional building blocks in terms of mechanical and electrical properties. Here we demonstrate a simple strategy for the fabrication of an open porous 3D self-organized double-hierarchical carbon nanotube tube stru...

journal_title：Nature communications

authors： Schütt F,Signetti S,Krüger H,Röder S,Smazna D,Kaps S,Gorb SN,Mishra YK,Pugno NM,Adelung R

更新日期：2017-10-31 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00

abstract：:G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe DC-34, a small molec...

journal_title：Nature communications

authors： Calabrese DR,Chen X,Leon EC,Gaikwad SM,Phyo Z,Hewitt WM,Alden S,Hilimire TA,He F,Michalowski AM,Simmons JK,Saunders LB,Zhang S,Connors D,Walters KJ,Mock BA,Schneekloth JS Jr

更新日期：2018-10-12 00:00:00

abstract：:Autophagosomes are double-membrane vesicles that sequester cytoplasmic material for lysosomal degradation. Their biogenesis is initiated by recruitment of Atg9-vesicles to the phagophore assembly site. This process depends on the regulated activation of the Atg1-kinase complex. However, the underlying molecular mechan...

journal_title：Nature communications

authors： Rao Y,Perna MG,Hofmann B,Beier V,Wollert T

更新日期：2016-01-12 00:00:00

abstract：:Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, there...

journal_title：Nature communications

authors： Nogueira R,Abolafia JM,Drugowitsch J,Balaguer-Ballester E,Sanchez-Vives MV,Moreno-Bote R

更新日期：2017-03-24 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppress...

journal_title：Nature communications

authors： Straub T,Freudenberg MA,Schleicher U,Bogdan C,Gasteiger G,Pircher H

更新日期：2018-10-08 00:00:00

abstract：:To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...

journal_title：Nature communications

authors： Chakraborty S,Arora A,Begg CB,Shen R

更新日期：2019-12-03 00:00:00

abstract：:Maintenance of working memory is thought to involve the activity of prefrontal neuronal populations with strong recurrent connections. However, it was recently shown that distractors evoke a morphing of the prefrontal population code, even when memories are maintained throughout the delay. How can a morphing code main...

journal_title：Nature communications

authors： Parthasarathy A,Tang C,Herikstad R,Cheong LF,Yen SC,Libedinsky C

更新日期：2019-11-01 00:00:00

abstract：:The realization of low-cost photodetectors with high sensitivity, high quantum efficiency, high gain and fast photoresponse in the visible and short-wave infrared remains one of the challenges in optoelectronics. Two classes of photodetectors that have been developed are photodiodes and phototransistors, each of them ...

journal_title：Nature communications

authors： Nikitskiy I,Goossens S,Kufer D,Lasanta T,Navickaite G,Koppens FH,Konstantatos G

更新日期：2016-06-17 00:00:00

abstract：:A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...

journal_title：Nature communications

authors： Devièse T,Massilani D,Yi S,Comeskey D,Nagel S,Nickel B,Ribechini E,Lee J,Tseveendorj D,Gunchinsuren B,Meyer M,Pääbo S,Higham T

更新日期：2019-01-30 00:00:00

abstract：:Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key e...

journal_title：Nature communications

authors： Infante P,Faedda R,Bernardi F,Bufalieri F,Lospinoso Severini L,Alfonsi R,Mazzà D,Siler M,Coni S,Po A,Petroni M,Ferretti E,Mori M,De Smaele E,Canettieri G,Capalbo C,Maroder M,Screpanti I,Kool M,Pfister SM,Guardavac

更新日期：2018-03-07 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and progressive weakness. There is considerable inter-patient variability in disease onset and progression, which can confound the results of clinical trials. Here we show that a common null polymorphism (R577X) in ACTN3 results in significantly...

journal_title：Nature communications

authors： Hogarth MW,Houweling PJ,Thomas KC,Gordish-Dressman H,Bello L,Cooperative International Neuromuscular Research Group (CINRG).,Pegoraro E,Hoffman EP,Head SI,North KN

更新日期：2017-01-31 00:00:00