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Are microtubules tension sensors?

Abstract：

:Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitude and direction. Here we propose a parsimonious mechanism for the perception of the principal stress direction. In vitro experiments show that microtubules are stabilized under tension. Based on these results, we explore the possibility that such microtubule stabilization operates in vivo, most notably in plant cells where turgor-driven tensile stresses exceed greatly those observed in animal cells.

journal_name

Nat Commun

journal_title

Nature communications

authors

Hamant O,Inoue D,Bouchez D,Dumais J,Mjolsness E

doi

10.1038/s41467-019-10207-y

subject

Has Abstract

pub_date

2019-05-29 00:00:00

pages

2360

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10207-y

journal_volume

10

pub_type

杂志文章,评审

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