Wall mechanics and exocytosis define the shape of growth domains in fission yeast.

abstract：:Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, on-demand products are currently missing from the PrEP deve...

journal_title：Nature communications

authors： Derby N,Lal M,Aravantinou M,Kizima L,Barnable P,Rodriguez A,Lai M,Wesenberg A,Ugaonkar S,Levendosky K,Mizenina O,Kleinbeck K,Lifson JD,Peet MM,Lloyd Z,Benson M,Heneine W,O'Keefe BR,Robbiani M,Martinelli E,Grasperg

更新日期：2018-09-24 00:00:00

abstract：:Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (...

journal_title：Nature communications

authors： Vandoorne T,Veys K,Guo W,Sicart A,Vints K,Swijsen A,Moisse M,Eelen G,Gounko NV,Fumagalli L,Fazal R,Germeys C,Quaegebeur A,Fendt SM,Carmeliet P,Verfaillie C,Van Damme P,Ghesquière B,De Bock K,Van Den Bosch L

更新日期：2019-09-12 00:00:00

abstract：:The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...

journal_title：Nature communications

authors： Liang W,Yao J,Chen A,Lv Q,Zanin M,Liu J,Wong S,Li Y,Lu J,Liang H,Chen G,Guo H,Guo J,Zhou R,Ou L,Zhou N,Chen H,Yang F,Han X,Huan W,Tang W,Guan W,Chen Z,Zhao Y,Sang L,Xu Y,Wang W,Li S,Lu L,Zhang N

更新日期：2020-07-15 00:00:00

abstract：:During plant radial growth typically seen in trees, procambial and cambial cells act as meristematic cells in the vascular system to self-proliferate and differentiate into xylem cells. These two processes are regulated by a signalling pathway composed of a peptide ligand and its receptor; tracheary element differenti...

journal_title：Nature communications

authors： Kondo Y,Ito T,Nakagami H,Hirakawa Y,Saito M,Tamaki T,Shirasu K,Fukuda H

更新日期：2014-03-24 00:00:00

abstract：:Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstra...

journal_title：Nature communications

authors： Li M,Zhi M,Zhu H,Wu WY,Xu QH,Jhon MH,Chan Y

更新日期：2015-09-30 00:00:00

abstract：:An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high...

journal_title：Nature communications

authors： You J,Dou L,Yoshimura K,Kato T,Ohya K,Moriarty T,Emery K,Chen CC,Gao J,Li G,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...

journal_title：Nature communications

authors： Li M,Wang X,Dong B,Sitti M

更新日期：2020-08-10 00:00:00

abstract：:Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression-methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a w...

journal_title：Nature communications

authors： Fleischer T,Tekpli X,Mathelier A,Wang S,Nebdal D,Dhakal HP,Sahlberg KK,Schlichting E,Oslo Breast Cancer Research Consortium (OSBREAC).,Børresen-Dale AL,Borgen E,Naume B,Eskeland R,Frigessi A,Tost J,Hurtado A,Kristensen VN

更新日期：2017-11-09 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result of non-radiative relaxation pathways, the plasmons in...

journal_title：Nature communications

authors： de Nijs B,Benz F,Barrow SJ,Sigle DO,Chikkaraddy R,Palma A,Carnegie C,Kamp M,Sundararaman R,Narang P,Scherman OA,Baumberg JJ

更新日期：2017-10-20 00:00:00

abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

journal_title：Nature communications

authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

更新日期：2013-01-01 00:00:00

abstract：:Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface ...

journal_title：Nature communications

authors： Wodlei F,Sebilleau J,Magnaudet J,Pimienta V

更新日期：2018-02-26 00:00:00

abstract：:Bipolaron states, in which two electrons or two holes occupy a single molecule or conjugated polymer segment, are typically considered to be negligible in organic semiconductor devices due to Coulomb repulsion between the two charges. Here we use charge modulation spectroscopy to reveal a bipolaron sheet density >1010...

journal_title：Nature communications

authors： Dhanker R,Gray CL,Mukhopadhyay S,Nunez S,Cheng CY,Sokolov AN,Giebink NC

更新日期：2017-12-21 00:00:00

abstract：:Topological superconductor is attracting growing interest for its potential application to topological quantum computation. The superconducting proximity effect on the topological insulator surface state is one promising way to yield topological superconductivity. The superconductivity realized at the interface betwee...

journal_title：Nature communications

authors： Yasuda K,Yasuda H,Liang T,Yoshimi R,Tsukazaki A,Takahashi KS,Nagaosa N,Kawasaki M,Tokura Y

更新日期：2019-06-21 00:00:00

abstract：:Plasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that...

journal_title：Nature communications

authors： Gessner S,Adli E,Allen JM,An W,Clarke CI,Clayton CE,Corde S,Delahaye JP,Frederico J,Green SZ,Hast C,Hogan MJ,Joshi C,Lindstrøm CA,Lipkowitz N,Litos M,Lu W,Marsh KA,Mori WB,O'Shea B,Vafaei-Najafabadi N,Walz D,Y

更新日期：2016-06-02 00:00:00

abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

journal_title：Nature communications

authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

更新日期：2014-08-08 00:00:00

abstract：:Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cance...

journal_title：Nature communications

authors： Zheng X,Wang X,Mao H,Wu W,Liu B,Jiang X

更新日期：2015-01-05 00:00:00

abstract：:The original version of this Article contained an error in Fig. 3. The scale bars in Figs 3c and 3d were incorrectly labelled as 50 μA. In the correct version, the scale bars are labelled as 0.5 μA. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Li X,Zhai T,Gao P,Cheng H,Hou R,Lou X,Xia F

更新日期：2018-02-08 00:00:00

abstract：:Plants influence extreme heat events by regulating land-atmosphere water and energy exchanges. The contribution of plants to changes in future heat extremes will depend on the responses of vegetation growth and physiology to the direct and indirect effects of elevated CO2. Here we use a suite of earth system models to...

journal_title：Nature communications

authors： Skinner CB,Poulsen CJ,Mankin JS

更新日期：2018-03-15 00:00:00

abstract：:Enhancers are critical for developmental stage-specific gene expression, but their dynamic regulation in plants remains poorly understood. Here we compare genome-wide localization of H3K27ac, chromatin accessibility and transcriptomic changes during flower development in Arabidopsis. H3K27ac prevalently marks promoter...

journal_title：Nature communications

authors： Yan W,Chen D,Schumacher J,Durantini D,Engelhorn J,Chen M,Carles CC,Kaufmann K

更新日期：2019-04-12 00:00:00

abstract：:The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β-barrel domain that is essential for OM protein biogenesis, but its mechanism of action is unknown. To elucidate its function, here we dev...

journal_title：Nature communications

authors： Doyle MT,Bernstein HD

更新日期：2019-07-26 00:00:00

abstract：:Arriving rapidly to the hospital after a heart attack or stroke is critical for patients to be within time windows for treatment. Prior research in heart attacks has suggested a paradoxical role of the social environment: those who arrive early are surrounded by nonrelatives, while those who arrive late are surrounded...

journal_title：Nature communications

authors： Dhand A,Luke D,Lang C,Tsiaklides M,Feske S,Lee JM

更新日期：2019-03-14 00:00:00

abstract：:Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibo...

journal_title：Nature communications

authors： Ku Z,Xie X,Davidson E,Ye X,Su H,Menachery VD,Li Y,Yuan Z,Zhang X,Muruato AE,I Escuer AG,Tyrell B,Doolan K,Doranz BJ,Wrapp D,Bates PF,McLellan JS,Weiss SR,Zhang N,Shi PY,An Z

更新日期：2021-01-20 00:00:00

abstract：:Vibrio parahaemolyticus is the leading cause of seafood-borne diarrheal diseases. Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decreased intestinal colonization, which suggests that T3SS1 repression is required for maximal virulence. However, the mechanisms by which T3SS1 ...

journal_title：Nature communications

authors： Gu D,Zhang Y,Wang Q,Zhou X

更新日期：2020-11-13 00:00:00

abstract：:Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively study the epigenetic dimension of cancer evolution, we integrate DNAme analysis with histone modification mappin...

journal_title：Nature communications

authors： Pastore A,Gaiti F,Lu SX,Brand RM,Kulm S,Chaligne R,Gu H,Huang KY,Stamenova EK,Béguelin W,Jiang Y,Schulman RC,Kim KT,Alonso A,Allan JN,Furman RR,Gnirke A,Wu CJ,Melnick AM,Meissner A,Bernstein BE,Abdel-Wahab O,L

更新日期：2019-04-23 00:00:00

abstract：:As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different types of cancer, chronic lymphocytic leukaemia and medulloblastoma, we conduct a benchmarking e...

journal_title：Nature communications

authors： Alioto TS,Buchhalter I,Derdak S,Hutter B,Eldridge MD,Hovig E,Heisler LE,Beck TA,Simpson JT,Tonon L,Sertier AS,Patch AM,Jäger N,Ginsbach P,Drews R,Paramasivam N,Kabbe R,Chotewutmontri S,Diessl N,Previti C,Schmidt S

更新日期：2015-12-09 00:00:00

abstract：:URu2Si2 is one of the most enigmatic strongly correlated electron systems and offers a fertile testing ground for new concepts in condensed matter science. In spite of >30 years of intense research, no consensus on the order parameter of its low-temperature hidden-order phase exists. A strong magnetic field transforms...

journal_title：Nature communications

authors： Knafo W,Duc F,Bourdarot F,Kuwahara K,Nojiri H,Aoki D,Billette J,Frings P,Tonon X,Lelièvre-Berna E,Flouquet J,Regnault LP

更新日期：2016-10-20 00:00:00

abstract：:Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...

journal_title：Nature communications

authors： Kruskal PB,Li L,MacLean JN

更新日期：2013-01-01 00:00:00

abstract：:The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult...

journal_title：Nature communications

authors： Carrascosa E,Meyer J,Zhang J,Stei M,Michaelsen T,Hase WL,Yang L,Wester R

更新日期：2017-06-21 00:00:00

abstract：:Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify...

journal_title：Nature communications

authors： Hiraoka Y,Matsuoka T,Ohno M,Nakamura K,Saijo S,Matsumura S,Nishi K,Sakamoto J,Chen PM,Inoue K,Fushiki T,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00