Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR.

abstract：:Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative...

journal_title：Nature communications

authors： Yamada M,Chen LJ,Yoo J,Wang S,Fox W,Jara-Almonte J,Ji H,Daughton W,Le A,Burch J,Giles B,Hesse M,Moore T,Torbert R

更新日期：2018-12-06 00:00:00

abstract：:Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of recepto...

journal_title：Nature communications

authors： Zhang Y,Su SS,Zhao S,Yang Z,Zhong CQ,Chen X,Cai Q,Yang ZH,Huang D,Wu R,Han J

更新日期：2017-02-08 00:00:00

abstract：:In LaAlO(3)/SrTiO(3) heterointerfaces, charge carriers migrate from the LaAlO(3) to the interface in an electronic reconstruction. Magnetism has been observed in LaAlO(3)/SrTiO(3), but its relationship to the interface conductivity is unknown. Here we show that reconstruction is necessary, but not sufficient, for the ...

journal_title：Nature communications

authors： Kalisky B,Bert JA,Klopfer BB,Bell C,Sato HK,Hosoda M,Hikita Y,Hwang HY,Moler KA

更新日期：2012-06-26 00:00:00

abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...

journal_title：Nature communications

authors： Porubsky D,Garg S,Sanders AD,Korbel JO,Guryev V,Lansdorp PM,Marschall T

更新日期：2017-11-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： McGlynn JC,Dankwort T,Kienle L,Bandeira NAG,Fraser JP,Gibson EK,Cascallana-Matías I,Kamarás K,Symes MD,Miras HN,Ganin AY

更新日期：2019-11-20 00:00:00

abstract：:The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....

journal_title：Nature communications

authors： Bunnik EM,Cook KB,Varoquaux N,Batugedara G,Prudhomme J,Cort A,Shi L,Andolina C,Ross LS,Brady D,Fidock DA,Nosten F,Tewari R,Sinnis P,Ay F,Vert JP,Noble WS,Le Roch KG

更新日期：2018-05-15 00:00:00

abstract：:Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...

journal_title：Nature communications

authors： Karl M,Glackin JME,Schubert M,Kronenberg NM,Turnbull GA,Samuel IDW,Gather MC

更新日期：2018-05-01 00:00:00

abstract：:Supercooling of aqueous solutions is a fundamentally and practically important physical phenomenon with numerous applications in biopreservation and beyond. Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume (> 1 ml), and low temperature...

journal_title：Nature communications

authors： Huang H,Yarmush ML,Usta OB

更新日期：2018-08-10 00:00:00

abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...

journal_title：Nature communications

authors： Joshi PK,Fischer K,Schraut KE,Campbell H,Esko T,Wilson JF

更新日期：2016-03-31 00:00:00

abstract：:The study of multicellular development is grounded in two complementary domains: cell biomechanics, which examines how physical forces shape the embryo, and genetic regulation and molecular signalling, which concern how cells determine their states and behaviours. Integrating both sides into a unified framework is cru...

journal_title：Nature communications

authors： Delile J,Herrmann M,Peyriéras N,Doursat R

更新日期：2017-01-23 00:00:00

abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...

journal_title：Nature communications

authors： Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A

更新日期：2015-10-28 00:00:00

abstract：:Insect vectors are required for the transmission of many species of parasitic nematodes, but the mechanisms by which the vectors and nematodes coordinate their life cycles are poorly understood. Here, we report that ascarosides, an evolutionarily conserved family of nematode pheromones, are produced not only by a plan...

journal_title：Nature communications

authors： Zhao L,Zhang X,Wei Y,Zhou J,Zhang W,Qin P,Chinta S,Kong X,Liu Y,Yu H,Hu S,Zou Z,Butcher RA,Sun J

更新日期：2016-08-01 00:00:00

abstract：:The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their po...

journal_title：Nature communications

authors： Kaittanis C,Shaffer TM,Ogirala A,Santra S,Perez JM,Chiosis G,Li Y,Josephson L,Grimm J

更新日期：2014-03-04 00:00:00

abstract：:Creating micro/nanostructures on fibers is beneficial for extending the application range of fiber-based devices. To achieve this using thermal fiber drawing is particularly important for the mass production of longitudinally uniform fibers up to tens of kilometers. However, the current thermal fiber drawing technique...

journal_title：Nature communications

authors： Wang Z,Wu T,Wang Z,Zhang T,Chen M,Zhang J,Liu L,Qi M,Zhang Q,Yang J,Liu W,Chen H,Luo Y,Wei L

更新日期：2020-07-31 00:00:00

abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

journal_title：Nature communications

authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

更新日期：2020-08-10 00:00:00

abstract：:X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...

journal_title：Nature communications

authors： Hsieh WC,Hsu TS,Chang YJ,Lai MZ

更新日期：2018-01-31 00:00:00

abstract：:Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histone arginine methyl-transferase PRMT5, a molecule catalyzing symmetric ...

journal_title：Nature communications

authors： Scaglione A,Patzig J,Liang J,Frawley R,Bok J,Mela A,Yattah C,Zhang J,Teo SX,Zhou T,Chen S,Bernstein E,Canoll P,Guccione E,Casaccia P

更新日期：2018-07-19 00:00:00

abstract：:Microbial fermentation of lignocellulosic biomass to produce industrial chemicals is exacerbated by the recalcitrant network of lignin, cellulose and hemicelluloses comprising the plant secondary cell wall. In this study, we show that transgenic poplar (Populus trichocarpa) lines can be solubilized without any pretrea...

journal_title：Nature communications

authors： Straub CT,Khatibi PA,Wang JP,Conway JM,Williams-Rhaesa AM,Peszlen IM,Chiang VL,Adams MWW,Kelly RM

更新日期：2019-08-07 00:00:00

abstract：:Hepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hep...

journal_title：Nature communications

authors： Winer BY,Huang TS,Pludwinski E,Heller B,Wojcik F,Lipkowitz GE,Parekh A,Cho C,Shrirao A,Muir TW,Novik E,Ploss A

更新日期：2017-07-25 00:00:00

abstract：:Models of visual attention postulate the existence of a saliency map whose function is to guide attention and gaze to the most conspicuous regions in a visual scene. Although cortical representations of saliency have been reported, there is mounting evidence for a subcortical saliency mechanism, which pre-dates the ev...

journal_title：Nature communications

authors： White BJ,Berg DJ,Kan JY,Marino RA,Itti L,Munoz DP

更新日期：2017-01-24 00:00:00

abstract：:Electrically pumped organic lasing is one of the most challenging issues in organic optoelectronics. We present a systematic theoretical investigation to screen out electrical pumping lasing molecules over a wide range of organic materials. With the electronic structure information obtained from time-dependent density...

journal_title：Nature communications

authors： Ou Q,Peng Q,Shuai Z

更新日期：2020-09-08 00:00:00

abstract：:Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

journal_title：Nature communications

authors： Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

更新日期：2015-07-14 00:00:00

abstract：:Magnetic skyrmion, a topologically stable spin-swirling object, can host emergent electromagnetism, as exemplified by the topological Hall effect and electric-current-driven skyrmion motion. To achieve efficient manipulation of nano-sized functional spin textures, it is imperative to exploit the resonant motion of sky...

journal_title：Nature communications

authors： Okamura Y,Kagawa F,Mochizuki M,Kubota M,Seki S,Ishiwata S,Kawasaki M,Onose Y,Tokura Y

更新日期：2013-01-01 00:00:00

abstract：:Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including modifications by mass spectrometry (MS). A critical limitation is sample input requirements that exceed many sources of clinically important material. Here we ...

journal_title：Nature communications

authors： Satpathy S,Jaehnig EJ,Krug K,Kim BJ,Saltzman AB,Chan DW,Holloway KR,Anurag M,Huang C,Singh P,Gao A,Namai N,Dou Y,Wen B,Vasaikar SV,Mutch D,Watson MA,Ma C,Ademuyiwa FO,Rimawi MF,Schiff R,Hoog J,Jacobs S,Malov

更新日期：2020-01-27 00:00:00

abstract：:Gas-sensing materials are becoming increasingly important in our society, requiring high sensitivity to differentiate similar gases like N2 and O2. For the design of such materials, the driving force of electronic host-guest interaction or host-framework changes during the sorption process has commonly been considered...

journal_title：Nature communications

authors： Kosaka W,Liu Z,Zhang J,Sato Y,Hori A,Matsuda R,Kitagawa S,Miyasaka H

更新日期：2018-12-21 00:00:00

abstract：:Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitu...

journal_title：Nature communications

authors： Hamant O,Inoue D,Bouchez D,Dumais J,Mjolsness E

更新日期：2019-05-29 00:00:00

abstract：:GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GFI1 is required in T...

journal_title：Nature communications

authors： Vadnais C,Chen R,Fraszczak J,Yu Z,Boulais J,Pinder J,Frank D,Khandanpour C,Hébert J,Dellaire G,Côté JF,Richard S,Orthwein A,Drobetsky E,Möröy T

更新日期：2018-04-12 00:00:00

abstract：:Around 40% of preterm births are attributed to ascending intrauterine infection, and Ureaplasma parvum (UP) is commonly isolated in these cases. Here we present a mouse model of ascending UP infection that resembles human disease, using vaginal inoculation combined with mild cervical injury induced by a common spermic...

journal_title：Nature communications

authors： Pavlidis I,Spiller OB,Sammut Demarco G,MacPherson H,Howie SEM,Norman JE,Stock SJ

更新日期：2020-01-10 00:00:00

abstract：:Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and mor...

journal_title：Nature communications

authors： Banjo T,Grajcarek J,Yoshino D,Osada H,Miyasaka KY,Kida YS,Ueki Y,Nagayama K,Kawakami K,Matsumoto T,Sato M,Ogura T

更新日期：2013-01-01 00:00:00

abstract：:Twisted Laguerre-Gaussian lasers, with orbital angular momentum and characterized by doughnut-shaped intensity profiles, provide a transformative set of tools and research directions in a growing range of fields and applications, from super-resolution microcopy and ultra-fast optical communications to quantum computin...

journal_title：Nature communications

authors： Vieira J,Trines RM,Alves EP,Fonseca RA,Mendonça JT,Bingham R,Norreys P,Silva LO

更新日期：2016-01-28 00:00:00