Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity.

abstract：:Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...

journal_title：Nature communications

authors： Jin M,O'Nuallain B,Hong W,Boyd J,Lagomarsino VN,O'Malley TT,Liu W,Vanderburg CR,Frosch MP,Young-Pearse T,Selkoe DJ,Walsh DM

更新日期：2018-07-11 00:00:00

abstract：:Topological insulators exhibit a metallic surface state in which the directions of the carriers' momentum and spin are locked together. This characteristic property, which lies at the heart of proposed applications of topological insulators, protects carriers in the surface state from back-scattering unless the scatte...

journal_title：Nature communications

authors： Nam MS,Williams BH,Chen Y,Contera S,Yao S,Lu M,Chen YF,Timco GA,Muryn CA,Winpenny REP,Ardavan A

更新日期：2018-01-04 00:00:00

abstract：:Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung ca...

journal_title：Nature communications

authors： Zhang XC,Wang J,Shao GG,Wang Q,Qu X,Wang B,Moy C,Fan Y,Albertyn Z,Huang X,Zhang J,Qiu Y,Platero S,Lorenzi MV,Zudaire E,Yang J,Cheng Y,Xu L,Wu YL

更新日期：2019-04-16 00:00:00

abstract：:Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...

journal_title：Nature communications

authors： Chung PED,Gendoo DMA,Ghanbari-Azarnier R,Liu JC,Jiang Z,Tsui J,Wang DY,Xiao X,Li B,Dubuc A,Shih D,Remke M,Ho B,Garzia L,Ben-David Y,Kang SG,Croul S,Haibe-Kains B,Huang A,Taylor MD,Zacksenhaus E

更新日期：2020-04-14 00:00:00

abstract：:Droplet-based microfluidic devices hold immense potential in becoming inexpensive alternatives to existing screening platforms across life science applications, such as enzyme discovery and early cancer detection. However, the lack of a predictive understanding of droplet generation makes engineering a droplet-based p...

journal_title：Nature communications

authors： Lashkaripour A,Rodriguez C,Mehdipour N,Mardian R,McIntyre D,Ortiz L,Campbell J,Densmore D

更新日期：2021-01-04 00:00:00

abstract：:Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...

journal_title：Nature communications

authors： Arnold F,Shekhar C,Wu SC,Sun Y,Dos Reis RD,Kumar N,Naumann M,Ajeesh MO,Schmidt M,Grushin AG,Bardarson JH,Baenitz M,Sokolov D,Borrmann H,Nicklas M,Felser C,Hassinger E,Yan B

更新日期：2016-05-17 00:00:00

abstract：:Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p a...

journal_title：Nature communications

authors： Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

更新日期：2015-10-05 00:00:00

abstract：:Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number variation and point ...

journal_title：Nature communications

authors： Dölle C,Flønes I,Nido GS,Miletic H,Osuagwu N,Kristoffersen S,Lilleng PK,Larsen JP,Tysnes OB,Haugarvoll K,Bindoff LA,Tzoulis C

更新日期：2016-11-22 00:00:00

abstract：:Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...

journal_title：Nature communications

authors： Stock MJ,Geist D,Neave DA,Gleeson MLM,Bernard B,Howard KA,Buisman I,Maclennan J

更新日期：2020-07-28 00:00:00

abstract：:Protein tyrosine phosphatases regulate a myriad of essential subcellular signaling events, yet they remain difficult to study in their native biophysical context. Here we develop a minimally disruptive optical approach to control protein tyrosine phosphatase 1B (PTP1B)-an important regulator of receptor tyrosine kinas...

journal_title：Nature communications

authors： Hongdusit A,Zwart PH,Sankaran B,Fox JM

更新日期：2020-02-07 00:00:00

abstract：:The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar material, PCM), and an atypical centriole (distal centriole, DC) ...

journal_title：Nature communications

authors： Fishman EL,Jo K,Nguyen QPH,Kong D,Royfman R,Cekic AR,Khanal S,Miller AL,Simerly C,Schatten G,Loncarek J,Mennella V,Avidor-Reiss T

更新日期：2018-06-07 00:00:00

abstract：:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...

journal_title：Nature communications

authors： Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi H

更新日期：2016-03-11 00:00:00

abstract：:The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor ...

journal_title：Nature communications

authors： Feierabend M,Berghäuser G,Knorr A,Malic E

更新日期：2017-03-15 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...

journal_title：Nature communications

authors： Setaro A,Adeli M,Glaeske M,Przyrembel D,Bisswanger T,Gordeev G,Maschietto F,Faghani A,Paulus B,Weinelt M,Arenal R,Haag R,Reich S

更新日期：2017-01-30 00:00:00

abstract：:Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisat...

journal_title：Nature communications

authors： Shin JJH,Crook OM,Borgeaud AC,Cattin-Ortolá J,Peak-Chew SY,Breckels LM,Gillingham AK,Chadwick J,Lilley KS,Munro S

更新日期：2020-11-25 00:00:00

abstract：:Electrocatalysts for oxygen reduction are a critical component that may dramatically enhance the performance of fuel cells and metal-air batteries, which may provide the power for future electric vehicles. Here we report a novel bio-inspired composite electrocatalyst, iron phthalocyanine with an axial ligand anchored ...

journal_title：Nature communications

authors： Cao R,Thapa R,Kim H,Xu X,Gyu Kim M,Li Q,Park N,Liu M,Cho J

更新日期：2013-01-01 00:00:00

abstract：:The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient het...

journal_title：Nature communications

authors： Desai N,Neyaz A,Szabolcs A,Shih AR,Chen JH,Thapar V,Nieman LT,Solovyov A,Mehta A,Lieb DJ,Kulkarni AS,Jaicks C,Xu KH,Raabe MJ,Pinto CJ,Juric D,Chebib I,Colvin RB,Kim AY,Monroe R,Warren SE,Danaher P,Reeves JW,

更新日期：2020-12-09 00:00:00

abstract：:Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remodelling INO80 complex promote...

journal_title：Nature communications

authors： Prendergast L,McClurg UL,Hristova R,Berlinguer-Palmini R,Greener S,Veitch K,Hernandez I,Pasero P,Rico D,Higgins JMG,Gospodinov A,Papamichos-Chronakis M

更新日期：2020-09-10 00:00:00

abstract：:Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the localization of other factors, including 53BP1, to DSB sites. Here, by using CRISPR-Cas9 engi...

journal_title：Nature communications

authors： Salguero I,Belotserkovskaya R,Coates J,Sczaniecka-Clift M,Demir M,Jhujh S,Wilson MD,Jackson SP

更新日期：2019-11-15 00:00:00

abstract：:In the original version of this Article, equation three contained a sign error whereby the term RT was added when it should have been subtracted. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Jung C,Bandilla P,von Reutern M,Schnepf M,Rieder S,Unnerstall U,Gaul U

更新日期：2019-02-05 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing ...

journal_title：Nature communications

authors： Kinoshita M,Kato R,Isa K,Kobayashi K,Kobayashi K,Onoe H,Isa T

更新日期：2019-01-11 00:00:00

abstract：:Eumelanin is a ubiquitous biological pigment, and the origin of its broadband absorption spectrum has long been a topic of scientific debate. Here, we report a first-principles computational investigation to explain its broadband absorption feature. These computations are complemented by experimental results showing a...

journal_title：Nature communications

authors： Chen CT,Chuang C,Cao J,Ball V,Ruch D,Buehler MJ

更新日期：2014-05-22 00:00:00

abstract：:Membranes with nano-apertures are versatile templates that possess a wide range of electronic, optical and biomedical applications. However, such membranes have been limited to silicon-based inorganic materials to utilize standard semiconductor processes. Here we report a new type of flexible and free-standing polymer...

journal_title：Nature communications

authors： Cho H,Kim J,Park H,Won Bang J,Seop Hyun M,Bae Y,Ha L,Yoon Kim D,Min Kang S,Jung Park T,Seo S,Choi M,Suh KY

更新日期：2014-01-01 00:00:00

abstract：:Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...

journal_title：Nature communications

authors： Skowron A,Lee DS,De León RR,Lim LL,Owen B

更新日期：2021-01-25 00:00:00

abstract：:It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

journal_title：Nature communications

authors： Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

更新日期：2014-04-28 00:00:00

abstract：:It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

journal_title：Nature communications

authors： Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

更新日期：2018-01-31 00:00:00

abstract：:The Ångström-sized probe of the scanning transmission electron microscope can visualize and collect spectra from single atoms. This can unambiguously resolve the chemical structure of materials, but not their isotopic composition. Here we differentiate between two isotopes of the same element by quantifying how likely...

journal_title：Nature communications

authors： Susi T,Hofer C,Argentero G,Leuthner GT,Pennycook TJ,Mangler C,Meyer JC,Kotakoski J

更新日期：2016-10-10 00:00:00

abstract：:Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...

journal_title：Nature communications

authors： Shen FY,Harrington MM,Walker LA,Cheng HPJ,Boyden ES,Cai D

更新日期：2020-09-15 00:00:00