Author Correction: Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane.

abstract：:Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc impact on their agonistic functions have been disputed. Here, we show that different natural human IgGs confer divergent ago...

journal_title：Nature communications

authors： Liu X,Zhao Y,Shi H,Zhang Y,Yin X,Liu M,Zhang H,He Y,Lu B,Jin T,Li F

更新日期：2019-09-27 00:00:00

abstract：:Microfluidics by soft lithography has proven to be of key importance for biophysics and life science research. While being based on replicating structures of a master mold using benchtop devices, design modifications are time consuming and require sophisticated cleanroom equipment. Here, we introduce virtual fluidic c...

journal_title：Nature communications

authors： Panhwar MH,Czerwinski F,Dabbiru VAS,Komaragiri Y,Fregin B,Biedenweg D,Nestler P,Pires RH,Otto O

更新日期：2020-05-04 00:00:00

abstract：:Due to the non-flammable nature of water-based electrolytes, aqueous lithium-ion batteries are resistant to catching fire. However, they are not immune to the risk of explosion, since the sealing structure adopted by current batteries limits the dissipation of heat and pressure within the cells. Here, we report a safe...

journal_title：Nature communications

authors： Chen L,Cao L,Ji X,Hou S,Li Q,Chen J,Yang C,Eidson N,Wang C

更新日期：2020-05-26 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often accompanied by obesity. In this study, we show that disruption of thioredoxin binding protein-2 (TBP-2, also called Txnip) in obese mice (ob/ob) dramatically improves hyp...

journal_title：Nature communications

authors： Yoshihara E,Fujimoto S,Inagaki N,Okawa K,Masaki S,Yodoi J,Masutani H

更新日期：2010-11-23 00:00:00

abstract：:In Drosophila melanogaster the single male chromosome X undergoes an average twofold transcriptional upregulation for balancing the transcriptional output between sexes. Previous literature hypothesised that a global change in chromosome structure may accompany this process. However, recent studies based on Hi-C faile...

journal_title：Nature communications

authors： Pal K,Forcato M,Jost D,Sexton T,Vaillant C,Salviato E,Mazza EMC,Lugli E,Cavalli G,Ferrari F

更新日期：2019-11-25 00:00:00

abstract：:In 2016 the World Health Organization identified 21 countries that could eliminate malaria by 2020. Monitoring progress towards this goal requires tracking ongoing transmission. Here we develop methods that estimate individual reproduction numbers and their variation through time and space. Individual reproduction num...

journal_title：Nature communications

authors： Routledge I,Chevéz JER,Cucunubá ZM,Rodriguez MG,Guinovart C,Gustafson KB,Schneider K,Walker PGT,Ghani AC,Bhatt S

更新日期：2018-06-26 00:00:00

abstract：:While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...

journal_title：Nature communications

authors： Chi C,Wang JQ,Hu HS,Zhang YY,Li WL,Meng L,Luo M,Zhou M,Li J

更新日期：2019-10-17 00:00:00

abstract：:The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...

journal_title：Nature communications

authors： Adhikari S,Nice EC,Deutsch EW,Lane L,Omenn GS,Pennington SR,Paik YK,Overall CM,Corrales FJ,Cristea IM,Van Eyk JE,Uhlén M,Lindskog C,Chan DW,Bairoch A,Waddington JC,Justice JL,LaBaer J,Rodriguez H,He F,Kostrzewa M

更新日期：2020-10-16 00:00:00

abstract：:Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expre...

journal_title：Nature communications

authors： Wei Y,de Lange SC,Scholtens LH,Watanabe K,Ardesch DJ,Jansen PR,Savage JE,Li L,Preuss TM,Rilling JK,Posthuma D,van den Heuvel MP

更新日期：2019-10-24 00:00:00

abstract：:Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been investigated. Here, we show that patients with newly diagnosed rheumatoid arthritis have expanded CD8+ T-cell clones...

journal_title：Nature communications

authors： Savola P,Kelkka T,Rajala HL,Kuuliala A,Kuuliala K,Eldfors S,Ellonen P,Lagström S,Lepistö M,Hannunen T,Andersson EI,Khajuria RK,Jaatinen T,Koivuniemi R,Repo H,Saarela J,Porkka K,Leirisalo-Repo M,Mustjoki S

更新日期：2017-06-21 00:00:00

abstract：:Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...

journal_title：Nature communications

authors： Touati SA,Buffin E,Cladière D,Hached K,Rachez C,van Deursen JM,Wassmann K

更新日期：2015-04-21 00:00:00

abstract：:The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...

journal_title：Nature communications

authors： Abid Ali F,Renault L,Gannon J,Gahlon HL,Kotecha A,Zhou JC,Rueda D,Costa A

更新日期：2016-02-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-08-14 00:00:00

abstract：:Potassium-ion batteries are a compelling technology for large scale energy storage due to their low-cost and good rate performance. However, the development of potassium-ion batteries remains in its infancy, mainly hindered by the lack of suitable cathode materials. Here we show that a previously known frustrated magn...

journal_title：Nature communications

authors： Ji B,Yao W,Zheng Y,Kidkhunthod P,Zhou X,Tunmee S,Sattayaporn S,Cheng HM,He H,Tang Y

更新日期：2020-03-06 00:00:00

abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

journal_title：Nature communications

authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

更新日期：2016-08-17 00:00:00

abstract：:As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

journal_title：Nature communications

authors： Davy M,Shi Z,Park J,Tian C,Genack AZ

更新日期：2015-04-20 00:00:00

abstract：:Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal l...

journal_title：Nature communications

authors： El-Kalliny MM,Wittig JH Jr,Sheehan TC,Sreekumar V,Inati SK,Zaghloul KA

更新日期：2019-01-14 00:00:00

abstract：:Self-assembly of electroactive molecules is a promising route to new types of functional semiconductors. Here we report a capsule-shaped molecule that assembles itself into a cellular semiconducting material. The interior space of the capsule with a volume of ~415 Å3 is a nanoenvironment that can accommodate a guest. ...

journal_title：Nature communications

authors： Zhang B,Hernández Sánchez R,Zhong Y,Ball M,Terban MW,Paley D,Billinge SJL,Ng F,Steigerwald ML,Nuckolls C

更新日期：2018-05-16 00:00:00

abstract：:The global urbanization rate is accelerating; however, data limitations have far prevented robust estimations of either global urban expansion or its effects on terrestrial net primary productivity (NPP). Here, using a high resolution dataset of global land use/cover (GlobeLand30), we show that global urban areas expa...

journal_title：Nature communications

authors： Liu X,Pei F,Wen Y,Li X,Wang S,Wu C,Cai Y,Wu J,Chen J,Feng K,Liu J,Hubacek K,Davis SJ,Yuan W,Yu L,Liu Z

更新日期：2019-12-05 00:00:00

abstract：:Textural properties provide information on the ingestibility, digestibility and state of ripeness or decay of sources of nutrition. Compared with our understanding of the chemosensory assessment of food, little is known about the mechanisms of texture detection. Here we show that Drosophila melanogaster can discrimina...

journal_title：Nature communications

authors： Sánchez-Alcañiz JA,Zappia G,Marion-Poll F,Benton R

更新日期：2017-01-27 00:00:00

abstract：:Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...

journal_title：Nature communications

authors： Hirano Y,Ihara K,Masuda T,Yamamoto T,Iwata I,Takahashi A,Awata H,Nakamura N,Takakura M,Suzuki Y,Horiuchi J,Okuno H,Saitoe M

更新日期：2016-11-14 00:00:00

abstract：:5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, an...

journal_title：Nature communications

authors： Li S,Dong M,Yang J,Cheng X,Shen X,Liu S,Wang ZQ,Gong XQ,Liu H,Han B

更新日期：2021-01-26 00:00:00

abstract：:The Earth's biggest magmatic events are believed to originate from massive melting when hot mantle plumes rising from the lowermost mantle reach the base of the lithosphere. Classical models predict large plume heads that cause kilometre-scale surface uplift, and narrow (100 km radius) plume tails that remain in the m...

journal_title：Nature communications

authors： Dannberg J,Sobolev SV

更新日期：2015-04-24 00:00:00

abstract：:Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which lead to high-level a...

journal_title：Nature communications

authors： Xing R,Zhou Y,Yu J,Yu Y,Nie Y,Luo W,Yang C,Xiong T,Wu WKK,Li Z,Bing Y,Lin S,Zhang Y,Hu Y,Li L,Han L,Yang C,Huang S,Huang S,Zhou R,Li J,Wu K,Fan D,Tang G,Dou J,Zhu Z,Ji J,Fang X,Lu Y

更新日期：2019-05-02 00:00:00

abstract：:Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment for melanoma. However, many patients do not display therapeutic response or eventually relapse. Moreover, patients treated with anti-PD-1 develop immune-related adverse events that can be cured with anti-tumor necrosis factor α (...

journal_title：Nature communications

authors： Bertrand F,Montfort A,Marcheteau E,Imbert C,Gilhodes J,Filleron T,Rochaix P,Andrieu-Abadie N,Levade T,Meyer N,Colacios C,Ségui B

更新日期：2017-12-22 00:00:00

abstract：:The same odorant can induce attractive or repulsive responses depending on its concentration in various animals including humans. However, little is understood about the neuronal basis of this behavioural phenomenon. Here we show that Caenorhabditis elegans avoids high concentrations of odorants that are attractive at...

journal_title：Nature communications

authors： Yoshida K,Hirotsu T,Tagawa T,Oda S,Wakabayashi T,Iino Y,Ishihara T

更新日期：2012-03-13 00:00:00

abstract：:Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces statistical variability and inaccurate re...

journal_title：Nature communications

authors： Kim TH,Wang Y,Oliver CR,Thamm DH,Cooling L,Paoletti C,Smith KJ,Nagrath S,Hayes DF

更新日期：2019-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Zheng J,Fan R,Wu H,Yao H,Yan Y,Liu J,Ran L,Sun Z,Yi L,Dang L,Gan P,Zheng P,Yang T,Zhang Y,Tang T,Wang Y

更新日期：2020-07-27 00:00:00

abstract：:The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p53, is frequently overexpressed in human tumors, indicating a proliferative advantage that it can confer to tu...

journal_title：Nature communications

authors： Li L,Li L,Li W,Chen T,Bin Zou,Zhao L,Wang H,Wang X,Xu L,Liu X,Wang D,Li B,Mak TW,Du W,Yang X,Jiang P

更新日期：2018-11-08 00:00:00