Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution.

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...

journal_title：Nature communications

authors： Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

更新日期：2020-11-02 00:00:00

abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...

journal_title：Nature communications

authors： Bénard A,Klimm K,Woodland AB,Arculus RJ,Wilke M,Botcharnikov RE,Shimizu N,Nebel O,Rivard C,Ionov DA

更新日期：2018-08-29 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00

abstract：:Scattering-type scanning near-field optical microscopy (s-SNOM) allows spectroscopic imaging with spatial resolution below the diffraction limit. With suitable light sources, s-SNOM is instrumental in numerous discoveries at the nanoscale. So far, the light sources have been limited to continuous wave or high-repetiti...

journal_title：Nature communications

authors： Wang H,Wang L,Xu XG

更新日期：2016-10-17 00:00:00

abstract：:Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...

journal_title：Nature communications

authors： Zhang Q,Li X,Ma Q,Zhang Q,Bai H,Yi W,Liu J,Han J,Xi G

更新日期：2017-04-24 00:00:00

abstract：:The development of stimulus-responsive polymeric materials is of great importance, especially for the development of remotely manipulated materials not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host-guest interactions and photoswitching ability in a hyd...

journal_title：Nature communications

authors： Takashima Y,Hatanaka S,Otsubo M,Nakahata M,Kakuta T,Hashidzume A,Yamaguchi H,Harada A

更新日期：2012-01-01 00:00:00

abstract：:New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...

journal_title：Nature communications

authors： Picón A,Lehmann CS,Bostedt C,Rudenko A,Marinelli A,Osipov T,Rolles D,Berrah N,Bomme C,Bucher M,Doumy G,Erk B,Ferguson KR,Gorkhover T,Ho PJ,Kanter EP,Krässig B,Krzywinski J,Lutman AA,March AM,Moonshiram D,Ray D,

更新日期：2016-05-23 00:00:00

abstract：:Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the binding affinities between their extracellular domains, an improved kinetic...

journal_title：Nature communications

authors： Lee JR,Bechstein DJ,Ooi CC,Patel A,Gaster RS,Ng E,Gonzalez LC,Wang SX

更新日期：2016-07-22 00:00:00

abstract：:Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...

journal_title：Nature communications

authors： Qian Q,Zhang J,Cui M,Han B

更新日期：2016-05-11 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...

journal_title：Nature communications

authors： Basiri-Esfahani S,Armin A,Forstner S,Bowen WP

更新日期：2019-01-10 00:00:00

abstract：:Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus Candida albicans. Soluble β-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monoc...

journal_title：Nature communications

authors： Halder LD,Jo EAH,Hasan MZ,Ferreira-Gomes M,Krüger T,Westermann M,Palme DI,Rambach G,Beyersdorf N,Speth C,Jacobsen ID,Kniemeyer O,Jungnickel B,Zipfel PF,Skerka C

更新日期：2020-05-11 00:00:00

abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

journal_title：Nature communications

authors： Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

更新日期：2019-01-14 00:00:00

abstract：:Trimethylation of histone H3 on lysine-4 (H3K4me3) is associated with gene-regulatory elements, but its transcription-independent function in cell division is unclear. CxxC-finger protein-1 (CFP1) is a major mediator of H3K4 trimethylation in mouse oocytes. Here we report that oocyte-specific knockout of Cxxc1, inhibi...

journal_title：Nature communications

authors： Sha QQ,Dai XX,Jiang JC,Yu C,Jiang Y,Liu J,Ou XH,Zhang SY,Fan HY

更新日期：2018-08-28 00:00:00

abstract：:A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be...

journal_title：Nature communications

authors： Qin J,Guo Y,Xue B,Shi P,Chen Y,Su QP,Hao H,Zhao S,Wu C,Yu L,Li D,Sun Y

更新日期：2020-09-08 00:00:00

abstract：:Thousands of tons of isotopic mixtures are processed annually for heavy-water production and tritium decontamination. The existing technologies remain extremely energy intensive and require large capital investments. New approaches are needed to reduce the industry's footprint. Recently, micrometre-size crystals of gr...

journal_title：Nature communications

authors： Lozada-Hidalgo M,Zhang S,Hu S,Esfandiar A,Grigorieva IV,Geim AK

更新日期：2017-05-09 00:00:00

abstract：:Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...

journal_title：Nature communications

authors： Gladyshev E,Kleckner N

更新日期：2014-04-03 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa. However, the crosstalk between these two signaling pathways remains unclear. Here we show tha...

journal_title：Nature communications

authors： Wang F,He Q,Yin J,Xu S,Hu W,Gu L

更新日期：2018-07-02 00:00:00

abstract：:Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning among bacterial isol...

journal_title：Nature communications

authors： Swenson TL,Karaoz U,Swenson JM,Bowen BP,Northen TR

更新日期：2018-01-02 00:00:00

abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...

journal_title：Nature communications

authors： Krah FS,Büntgen U,Schaefer H,Müller J,Andrew C,Boddy L,Diez J,Egli S,Freckleton R,Gange AC,Halvorsen R,Heegaard E,Heideroth A,Heibl C,Heilmann-Clausen J,Høiland K,Kar R,Kauserud H,Kirk PM,Kuyper TW,Krisai-Greilhub

更新日期：2019-06-28 00:00:00

abstract：:Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...

journal_title：Nature communications

authors： Lencz T,Guha S,Liu C,Rosenfeld J,Mukherjee S,DeRosse P,John M,Cheng L,Zhang C,Badner JA,Ikeda M,Iwata N,Cichon S,Rietschel M,Nöthen MM,Cheng AT,Hodgkinson C,Yuan Q,Kane JM,Lee AT,Pisanté A,Gregersen PK,Pe'er I

更新日期：2013-01-01 00:00:00

abstract：:dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regulation. dDsk2 interacts with the dHP1c complex, localizes at promoters of developmental genes and is required for transcription. T...

journal_title：Nature communications

authors： Kessler R,Tisserand J,Font-Burgada J,Reina O,Coch L,Attolini CS,Garcia-Bassets I,Azorín F

更新日期：2015-04-28 00:00:00

abstract：:The turnover of messenger RNAs (mRNAs) is a key regulatory step of gene expression in eukaryotic cells. Due to the complexity of the mammalian degradation machinery, the contribution of decay factors to the directionality of mRNA decay is poorly understood. Here we characterize a molecular tool to interrogate mRNA tur...

journal_title：Nature communications

authors： Boehm V,Gerbracht JV,Marx MC,Gehring NH

更新日期：2016-12-05 00:00:00

abstract：:Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malign...

journal_title：Nature communications

authors： Ma R,Zhang W,Tang K,Zhang H,Zhang Y,Li D,Li Y,Xu P,Luo S,Cai W,Ji T,Katirai F,Ye D,Huang B

更新日期：2013-01-01 00:00:00

abstract：:Multiple hypotheses propose an ostensibly disparate array of drivers of food chain length (FCL), with contradictory support from natural settings. Here we posit that the magnitude of vertical energy flux in food webs underlies several drivers of FCL. We show that rising energy flux fuels top-heavy biomass pyramids, pr...

journal_title：Nature communications

authors： Ward CL,McCann KS

更新日期：2017-12-11 00:00:00

abstract：:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily ch...

journal_title：Nature communications

authors： Asokan MM,Williamson RS,Hancock KE,Polley DB

更新日期：2018-06-25 00:00:00

abstract：:Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be altered either wit...

journal_title：Nature communications

authors： Eroshenko N,Church GM

更新日期：2013-01-01 00:00:00