Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.

abstract：:Biodiversity changes are lagging behind current climate warming. The underlying determinants of this climatic debt are unknown and yet critical to understand the impacts of climate change on the present biota and improve forecasts of biodiversity changes. Here we assess determinants of climatic debt accumulated in Fre...

journal_title：Nature communications

authors： Bertrand R,Riofrío-Dillon G,Lenoir J,Drapier J,de Ruffray P,Gégout JC,Loreau M

更新日期：2016-08-26 00:00:00

abstract：:Seismic tomography provides unique constraints on the morphology, the deformation, and (indirectly) the rheology of subducting slabs. We use teleseismic double-difference P-wave tomography to image with unprecedented clarity the structural complexity of the Izu-Bonin slab. We resolve a tear in the slab in the mantle t...

journal_title：Nature communications

authors： Zhang H,Wang F,Myhill R,Guo H

更新日期：2019-03-21 00:00:00

abstract：:Quantum magnets provide the simplest example of strongly interacting quantum matter, yet they continue to resist a comprehensive understanding above one spatial dimension. We explore a promising framework in two dimensions, the Dirac spin liquid (DSL) - quantum electrodynamics (QED3) with 4 Dirac fermions coupled to p...

journal_title：Nature communications

authors： Song XY,Wang C,Vishwanath A,He YC

更新日期：2019-09-18 00:00:00

abstract：:A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...

journal_title：Nature communications

authors： Yang M,Li CJ,Sun X,Guo Q,Xiao Y,Su T,Tu ML,Peng H,Lu Q,Liu Q,He HB,Jiang TJ,Lei MX,Wan M,Cao X,Luo XH

更新日期：2017-07-07 00:00:00

abstract：:Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...

journal_title：Nature communications

authors： Chatelain L,Louyriac E,Douair I,Lu E,Tuna F,Wooles AJ,Gardner BM,Maron L,Liddle ST

更新日期：2020-01-17 00:00:00

abstract：:We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...

journal_title：Nature communications

authors： Zhang X,Liao Q,Liu S,Kang Z,Zhang Z,Du J,Li F,Zhang S,Xiao J,Liu B,Ou Y,Liu X,Gu L,Zhang Y

更新日期：2017-06-22 00:00:00

abstract：:The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...

journal_title：Nature communications

authors： Mihnev MT,Kadi F,Divin CJ,Winzer T,Lee S,Liu CH,Zhong Z,Berger C,de Heer WA,Malic E,Knorr A,Norris TB

更新日期：2016-05-25 00:00:00

abstract：:xrRNAs from flaviviruses survive in host cells because of their exceptional dichotomic response to the unfolding action of different enzymes. They can be unwound, and hence copied, by replicases, and yet can resist degradation by exonucleases. How the same stretch of xrRNA can encode such diverse responses is an open ...

journal_title：Nature communications

authors： Suma A,Coronel L,Bussi G,Micheletti C

更新日期：2020-07-27 00:00:00

abstract：:Room-temperature infrared sub-band gap photoresponse in silicon is of interest for telecommunications, imaging and solid-state energy conversion. Attempts to induce infrared response in silicon largely centred on combining the modification of its electronic structure via controlled defect formation (for example, vacan...

journal_title：Nature communications

authors： Mailoa JP,Akey AJ,Simmons CB,Hutchinson D,Mathews J,Sullivan JT,Recht D,Winkler MT,Williams JS,Warrender JM,Persans PD,Aziz MJ,Buonassisi T

更新日期：2014-01-01 00:00:00

abstract：:Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...

journal_title：Nature communications

authors： Runge J,Petoukhov V,Donges JF,Hlinka J,Jajcay N,Vejmelka M,Hartman D,Marwan N,Paluš M,Kurths J

更新日期：2015-10-07 00:00:00

abstract：:Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...

journal_title：Nature communications

authors： Apaolaza I,San José-Eneriz E,Tobalina L,Miranda E,Garate L,Agirre X,Prósper F,Planes FJ

更新日期：2017-09-06 00:00:00

abstract：:Folding processes play a crucial role in the development of function in biomacromolecules. Recreating this feature on synthetic systems would not only allow understanding and reproducing biological functions but also developing new functions. This has inspired the development of conformationally ordered synthetic olig...

journal_title：Nature communications

authors： Carini M,Ruiz MP,Usabiaga I,Fernández JA,Cocinero EJ,Melle-Franco M,Diez-Perez I,Mateo-Alonso A

更新日期：2017-05-18 00:00:00

abstract：:Deep subwavelength integration of high-definition plasmonic nanostructures is of key importance in the development of future optical nanocircuitry for high-speed communication, quantum computation and lab-on-a-chip applications. To date, the experimental realization of proposed extended plasmonic networks consisting o...

journal_title：Nature communications

authors： Huang JS,Callegari V,Geisler P,Brüning C,Kern J,Prangsma JC,Wu X,Feichtner T,Ziegler J,Weinmann P,Kamp M,Forchel A,Biagioni P,Sennhauser U,Hecht B

更新日期：2010-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15587. ...

journal_title：Nature communications

authors： Yu T,Zhou YJ,Wenning L,Liu Q,Krivoruchko A,Siewers V,Nielsen J,David F

更新日期：2018-07-13 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show th...

journal_title：Nature communications

authors： Hirori H,Shinokita K,Shirai M,Tani S,Kadoya Y,Tanaka K

更新日期：2011-12-20 00:00:00

abstract：:Efficient organic light-emitting diodes have been developed using emitters containing rare metals, such as platinum and iridium complexes. However, there is an urgent need to develop emitters composed of more abundant materials. Here we show a thermally activated delayed fluorescence material for organic light-emittin...

journal_title：Nature communications

authors： Kaji H,Suzuki H,Fukushima T,Shizu K,Suzuki K,Kubo S,Komino T,Oiwa H,Suzuki F,Wakamiya A,Murata Y,Adachi C

更新日期：2015-10-19 00:00:00

abstract：:Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps (NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been documented for other cells and organisms, thus highlighting the evolutionary conservation of this process. Moreover, dysregulated NETosis has be...

journal_title：Nature communications

authors： Neubert E,Meyer D,Rocca F,Günay G,Kwaczala-Tessmann A,Grandke J,Senger-Sander S,Geisler C,Egner A,Schön MP,Erpenbeck L,Kruss S

更新日期：2018-09-14 00:00:00

abstract：:In weakly spin-orbit coupled materials, the spin-selective nature of recombination can give rise to large magnetic-field effects, e.g. on the electro-luminescence of molecular semiconductors. Although silicon has weak spin-orbit coupling, observing spin-dependent recombination through magneto-electroluminescence is ch...

journal_title：Nature communications

authors： Chiodi F,Bayliss SL,Barast L,Débarre D,Bouchiat H,Friend RH,Chepelianskii AD

更新日期：2018-01-26 00:00:00

abstract：:NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...

journal_title：Nature communications

authors： Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R

更新日期：2018-12-05 00:00:00

abstract：:Active biofluid management is central to the realization of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, here, a programmable epidermal microfluidic valving system is de...

journal_title：Nature communications

authors： Lin H,Tan J,Zhu J,Lin S,Zhao Y,Yu W,Hojaiji H,Wang B,Yang S,Cheng X,Wang Z,Tang E,Yeung C,Emaminejad S

更新日期：2020-09-02 00:00:00

abstract：:Dynamics are fundamental to the functions of biomolecules and can occur on a wide range of time and length scales. Here we develop and apply high-speed AFM height spectroscopy (HS-AFM-HS), a technique whereby we monitor the sensing of a HS-AFM tip at a fixed position to directly detect the motions of unlabeled molecul...

journal_title：Nature communications

authors： Heath GR,Scheuring S

更新日期：2018-11-26 00:00:00

abstract：:Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...

journal_title：Nature communications

authors： Huang W,Peng Y,Kiselar J,Zhao X,Albaqami A,Mendez D,Chen Y,Chakravarthy S,Gupta S,Ralston C,Kao HY,Chance MR,Yang S

更新日期：2018-08-30 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Chen S,Wang Q,Yu H,Capitano ML,Vemula S,Nabinger SC,Gao R,Yao C,Kobayashi M,Geng Z,Fahey A,Henley D,Liu SZ,Barajas S,Cai W,Wolf ER,Ramdas B,Cai Z,Gao H,Luo N,Sun Y,Wong TN,Link DC,Liu Y,Boswell HS,Mayo L

更新日期：2020-07-28 00:00:00

abstract：:Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling. A protein corona is a protein l...

journal_title：Nature communications

authors： Blume JE,Manning WC,Troiano G,Hornburg D,Figa M,Hesterberg L,Platt TL,Zhao X,Cuaresma RA,Everley PA,Ko M,Liou H,Mahoney M,Ferdosi S,Elgierari EM,Stolarczyk C,Tangeysh B,Xia H,Benz R,Siddiqui A,Carr SA,Ma P,Lan

更新日期：2020-07-22 00:00:00

abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...

journal_title：Nature communications

authors： Krishnan ML,Van Steenwinckel J,Schang AL,Yan J,Arnadottir J,Le Charpentier T,Csaba Z,Dournaud P,Cipriani S,Auvynet C,Titomanlio L,Pansiot J,Ball G,Boardman JP,Walley AJ,Saxena A,Mirza G,Fleiss B,Edwards AD,Petretto

更新日期：2017-09-05 00:00:00

abstract：:Proximity-ligation methods such as Hi-C allow us to map physical DNA-DNA interactions along the genome, and reveal its organization into topologically associating domains (TADs). As the Hi-C data accumulate, computational methods were developed for identifying domain borders in multiple cell types and organisms. Here,...

journal_title：Nature communications

authors： Ron G,Globerson Y,Moran D,Kaplan T

更新日期：2017-12-21 00:00:00

abstract：:Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation...

journal_title：Nature communications

authors： Díaz-Muñoz MD,Kiselev VY,Le Novère N,Curk T,Ule J,Turner M

更新日期：2017-09-13 00:00:00

abstract：:Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary s...

journal_title：Nature communications

authors： Pazoki R,Evangelou E,Mosen-Ansorena D,Pinto RC,Karaman I,Blakeley P,Gill D,Zuber V,Elliott P,Tzoulaki I,Dehghan A

更新日期：2019-08-13 00:00:00

abstract：:Water resources are being challenged to meet domestic, agricultural, and industrial needs. To complement finite surface water supplies that are being stressed by changes in precipitation and increased demand, groundwater is increasingly being used. Sustaining groundwater use requires considering both water quantity an...

journal_title：Nature communications

authors： Smith R,Knight R,Fendorf S

更新日期：2018-06-05 00:00:00