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Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro.

Abstract：

:Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing culture-induced dedifferentiation of adult cardiac tissue using rat, rabbit and human heart failure myocardial slices. Here we report that the application of a preload equivalent to sarcomere length (SL) = 2.2 μm is optimal for the maintenance of rat myocardial slice structural, functional and transcriptional properties at 24 h. Gene sets associated with the preservation of structure and function are activated, while gene sets involved in dedifferentiation are suppressed. The maximum contractility of human heart failure myocardial slices at 24 h is also optimally maintained at SL = 2.2 μm. Rabbit myocardial slices cultured at SL = 2.2 μm remain stable for 5 days. This approach substantially prolongs the culture of adult cardiac tissue in vitro.

journal_name

Nat Commun

journal_title

Nature communications

authors

Watson SA,Duff J,Bardi I,Zabielska M,Atanur SS,Jabbour RJ,Simon A,Tomas A,Smolenski RT,Harding SE,Perbellini F,Terracciano CM

doi

10.1038/s41467-019-10175-3

subject

Has Abstract

pub_date

2019-05-15 00:00:00

pages

2168

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10175-3

journal_volume

10

pub_type

杂志文章

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