Stabilizing hidden room-temperature ferroelectricity via a metastable atomic distortion pattern.

abstract：:The manipulation of crystal orientation from the thermodynamic equilibrium states is desired in layered hybrid perovskite films to direct charge transport and enhance the perovskite devices performance. Here we report a templated growth mechanism of layered perovskites from 3D-like perovskites which can be a general d...

journal_title：Nature communications

authors： Wang J,Luo S,Lin Y,Chen Y,Deng Y,Li Z,Meng K,Chen G,Huang T,Xiao S,Huang H,Zhou C,Ding L,He J,Huang J,Yuan Y

更新日期：2020-01-29 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) are effectors of transposable element (TE) silencing in the reproductive apparatus. In Drosophila ovarian somatic cells, piRNAs arise from longer single-stranded RNA precursors that are processed in the cytoplasm presumably within the Yb-bodies. piRNA precursors encoded by the flamenco (...

journal_title：Nature communications

authors： Dennis C,Brasset E,Sarkar A,Vaury C

更新日期：2016-12-08 00:00:00

abstract：:The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study, we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 for localizing to the ciliary inversin compartment (IC) and activates NEK8 by binding to its ki...

journal_title：Nature communications

authors： Czarnecki PG,Gabriel GC,Manning DK,Sergeev M,Lemke K,Klena NT,Liu X,Chen Y,Li Y,San Agustin JT,Garnaas MK,Francis RJ,Tobita K,Goessling W,Pazour GJ,Lo CW,Beier DR,Shah JV

更新日期：2015-01-20 00:00:00

abstract：:Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...

journal_title：Nature communications

authors： Peng W,Song R,Acar M

更新日期：2016-10-03 00:00:00

abstract：:The advent and growth of synthetic biology has demonstrated its potential as a promising avenue of research to address many societal needs. However, plant synthetic biology efforts have been hampered by a dearth of DNA part libraries, versatile transformation vectors and efficient assembly strategies. Here, we describ...

journal_title：Nature communications

authors： Shih PM,Vuu K,Mansoori N,Ayad L,Louie KB,Bowen BP,Northen TR,Loqué D

更新日期：2016-10-26 00:00:00

abstract：:Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role of proteostasis involved in next generation anti-androgen resist...

journal_title：Nature communications

authors： Liu C,Lou W,Yang JC,Liu L,Armstrong CM,Lombard AP,Zhao R,Noel ODV,Tepper CG,Chen HW,Dall'Era M,Evans CP,Gao AC

更新日期：2018-11-16 00:00:00

abstract：:ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (...

journal_title：Nature communications

authors： Wu C,Lyu J,Yang EJ,Liu Y,Zhang B,Shim JS

更新日期：2018-08-10 00:00:00

abstract：:Excitons are spin integer particles that are predicted to condense into a coherent quantum state at sufficiently low temperature. Here by using photocurrent imaging we report experimental evidence of formation and efficient transport of non-equilibrium excitons in Bi2-xSbxSe3 nanoribbons. The photocurrent distribution...

journal_title：Nature communications

authors： Hou Y,Wang R,Xiao R,McClintock L,Clark Travaglini H,Paulus Francia J,Fetsch H,Erten O,Savrasov SY,Wang B,Rossi A,Vishik I,Rotenberg E,Yu D

更新日期：2019-12-16 00:00:00

abstract：:Global climate change has intensified the need to assess the capacity for natural populations to adapt to abrupt shifts in the environment. Reductions in seawater pH constitute a conspicuous global change stressor that is affecting marine ecosystems globally. Here, we quantify the phenotypic and genetic modifications ...

journal_title：Nature communications

authors： Bitter MC,Kapsenberg L,Gattuso JP,Pfister CA

更新日期：2019-12-20 00:00:00

abstract：:Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...

journal_title：Nature communications

authors： Feng Q,Yang L,Zhong Y,Guo D,Liu G,Xie L,Huang W,Tong R

更新日期：2018-04-19 00:00:00

abstract：:Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...

journal_title：Nature communications

authors： Guo W,Xin M,Wang Z,Yao Y,Hu Z,Song W,Yu K,Chen Y,Wang X,Guan P,Appels R,Peng H,Ni Z,Sun Q

更新日期：2020-10-08 00:00:00

abstract：:Efficient and reliable on-chip optical amplifiers and light sources would enable versatile integration of various active functionalities on the silicon platform. Although lasing on silicon has been demonstrated with semiconductors by using methods such as wafer bonding or molecular beam epitaxy, cost-effective mass pr...

journal_title：Nature communications

authors： Rönn J,Zhang W,Autere A,Leroux X,Pakarinen L,Alonso-Ramos C,Säynätjoki A,Lipsanen H,Vivien L,Cassan E,Sun Z

更新日期：2019-01-25 00:00:00

abstract：:The electronic properties of graphene are described by a Dirac Hamiltonian with a four-fold symmetry of spin and valley. This symmetry may yield novel fractional quantum Hall (FQH) states at high magnetic field depending on the relative strength of symmetry-breaking interactions. However, observing such states in tran...

journal_title：Nature communications

authors： Amet F,Bestwick AJ,Williams JR,Balicas L,Watanabe K,Taniguchi T,Goldhaber-Gordon D

更新日期：2015-01-06 00:00:00

abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

journal_title：Nature communications

authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

更新日期：2017-11-23 00:00:00

abstract：:Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to interrogate functional elements in noncoding regions requires generating sgRNA libraries that are densely covering,...

journal_title：Nature communications

authors： Cheng J,Roden CA,Pan W,Zhu S,Baccei A,Pan X,Jiang T,Kluger Y,Weissman SM,Guo S,Flavell RA,Ding Y,Lu J

更新日期：2016-03-30 00:00:00

abstract：:Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcri...

journal_title：Nature communications

authors： Aramillo Irizar P,Schäuble S,Esser D,Groth M,Frahm C,Priebe S,Baumgart M,Hartmann N,Marthandan S,Menzel U,Müller J,Schmidt S,Ast V,Caliebe A,König R,Krawczak M,Ristow M,Schuster S,Cellerino A,Diekmann S,Englert C

更新日期：2018-01-30 00:00:00

abstract：:Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by constitutive deficiency of global genome nucleotide excision repair (GG-NER). The genetic mechanisms of non-skin cancers in XP-C patients remain unexplo...

journal_title：Nature communications

authors： Yurchenko AA,Padioleau I,Matkarimov BT,Soulier J,Sarasin A,Nikolaev S

更新日期：2020-11-17 00:00:00

abstract：:Despite the fundamental importance of efficient and selective synthesis of widely useful alkylarenes, the direct catalytic C(sp2)-H alkylation of unactivated arenes with a readily available alkyl halide remains elusive. Here, we report the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromid...

journal_title：Nature communications

authors： Kim D,Lee GS,Kim D,Hong SH

更新日期：2020-10-19 00:00:00

abstract：:During bacterial cell division, the tubulin-homolog FtsZ forms a ring-like structure at the center of the cell. This Z-ring not only organizes the division machinery, but treadmilling of FtsZ filaments was also found to play a key role in distributing proteins at the division site. What regulates the architecture, dyn...

journal_title：Nature communications

authors： Caldas P,López-Pelegrín M,Pearce DJG,Budanur NB,Brugués J,Loose M

更新日期：2019-12-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

更新日期：2019-08-21 00:00:00

abstract：:The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bi...

journal_title：Nature communications

authors： Rodríguez JF,Saco PM,Sandi S,Saintilan N,Riccardi G

更新日期：2017-07-13 00:00:00

abstract：:Non-covalent π-π interactions are central to chemical and biological processes, yet the full understanding of their origin that would unite the simplicity of empirical approaches with the accuracy of quantum calculations is still missing. Here we employ a quantum-mechanical Hamiltonian model for van der Waals interact...

journal_title：Nature communications

authors： Hermann J,Alfè D,Tkatchenko A

更新日期：2017-02-07 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 ...

journal_title：Nature communications

authors： Rej E,Gaebel T,Boele T,Waddington DE,Reilly DJ

更新日期：2015-10-09 00:00:00

abstract：:While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generat...

journal_title：Nature communications

authors： Mace EM,Gunesch JT,Dixon A,Orange JS

更新日期：2016-07-20 00:00:00

abstract：:The insulator-metal transition (IMT) of vanadium dioxide (VO2) has remained a long-standing challenge in correlated electron physics since its discovery five decades ago. Most interpretations of experimental observations have implicitly assumed a homogeneous material response. Here we reveal inhomogeneous behaviour of...

journal_title：Nature communications

authors： O'Callahan BT,Jones AC,Hyung Park J,Cobden DH,Atkin JM,Raschke MB

更新日期：2015-04-21 00:00:00

abstract：:Lithium metal is an ideal anode for lithium batteries due to its low electrochemical potential and high theoretical capacity. However, safety issues arising from lithium dendrite growth have significantly reduced the practical applicability of lithium metal batteries. Here, we report the addition of octaphenyl polyoxy...

journal_title：Nature communications

authors： Dai H,Gu X,Dong J,Wang C,Lai C,Sun S

更新日期：2020-01-31 00:00:00

abstract：:Cryo-electron microscopy can determine the structure of biological matter in vitrified liquids. However, structure alone is insufficient to understand the function of native and engineered biomolecules. So far, their mechanical properties have mainly been probed at room temperature using tens of pico-newton forces wit...

journal_title：Nature communications

authors： Pawlak R,Vilhena JG,Hinaut A,Meier T,Glatzel T,Baratoff A,Gnecco E,Pérez R,Meyer E

更新日期：2019-02-08 00:00:00

abstract：:Human-machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. He...

journal_title：Nature communications

authors： Lee Y,Cha SH,Kim YW,Choi D,Sun JY

更新日期：2018-05-04 00:00:00

abstract：:Graphene and carbon nanotubes are envisaged as suitable materials for the fabrication of the new generation of nanoelectronics. The controlled patterning of such nanostructures with metal nanoparticles is conditioned by the transfer between a recipient and the surface to pattern. Electromigration under the impact of a...

journal_title：Nature communications

authors： Melinte G,Moldovan S,Hirlimann C,Liu X,Bégin-Colin S,Bégin D,Banhart F,Pham-Huu C,Ersen O

更新日期：2015-08-28 00:00:00