当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Mutation bias and GC content shape antimutator invasions.

Mutation bias and GC content shape antimutator invasions.

Abstract：

:Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we show that a largely neglected factor, the mutational idiosyncrasy displayed by different mutators, can play a major role in this process. Analysing phylogenetically diverse bacteria, we find marked and systematic differences in the protein-disruptive effects of mutations caused by different mutators in species with different GC compositions. Computer simulations show that these differences can account for order-of-magnitude changes in antimutator fitness for a realistic range of parameters. Overall, our results suggest that antimutator dynamics may be highly dependent on the specific genetic, ecological and evolutionary history of a given population. This context-dependency further complicates our understanding of mutators in clinical settings, as well as their role in shaping bacterial genome size and composition.

journal_name

Nat Commun

journal_title

Nature communications

authors

Couce A,Tenaillon O

doi

10.1038/s41467-019-11217-6

subject

Has Abstract

pub_date

2019-07-15 00:00:00

pages

3114

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11217-6

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase.

    abstract：:Aerobic methane oxidation is catalyzed by particulate methane monooxygenase (pMMO), a copper-dependent, membrane metalloenzyme composed of subunits PmoA, PmoB, and PmoC. Characterization of the copper active site has been limited by challenges in spectroscopic analysis stemming from the presence of multiple copper bin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10590-6

    authors： Ro SY,Schachner LF,Koo CW,Purohit R,Remis JP,Kenney GE,Liauw BW,Thomas PM,Patrie SM,Kelleher NL,Rosenzweig AC

    更新日期：2019-06-17 00:00:00

  • Simulation of non-Abelian gauge theories with optical lattices.

    abstract：:Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3615

    authors： Tagliacozzo L,Celi A,Orland P,Mitchell MW,Lewenstein M

    更新日期：2013-01-01 00:00:00

  • Wave-driven butterfly distribution of Van Allen belt relativistic electrons.

    abstract：:Van Allen radiation belts consist of relativistic electrons trapped by Earth's magnetic field. Trapped electrons often drift azimuthally around Earth and display a butterfly pitch angle distribution of a minimum at 90° further out than geostationary orbit. This is usually attributed to drift shell splitting resulting ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9590

    authors： Xiao F,Yang C,Su Z,Zhou Q,He Z,He Y,Baker DN,Spence HE,Funsten HO,Blake JB

    更新日期：2015-10-05 00:00:00

  • A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia.

    abstract：:Hypoxia occurs when limited oxygen supply impairs physiological functions and is a pathological hallmark of many diseases including cancer and ischemia. Thus, detection of hypoxia can guide treatment planning and serve as a predictor of patient prognosis. Unfortunately, current methods suffer from invasiveness, poor r...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01951-0

    authors： Knox HJ,Hedhli J,Kim TW,Khalili K,Dobrucki LW,Chan J

    更新日期：2017-11-27 00:00:00

  • Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

    abstract：:Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors including BMS-818251,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07851-1

    authors： Lai YT,Wang T,O'Dell S,Louder MK,Schön A,Cheung CSF,Chuang GY,Druz A,Lin B,McKee K,Peng D,Yang Y,Zhang B,Herschhorn A,Sodroski J,Bailer RT,Doria-Rose NA,Mascola JR,Langley DR,Kwong PD

    更新日期：2019-01-03 00:00:00

  • Emergent honeycomb network of topological excitations in correlated charge density wave.

    abstract：:When two periodic potentials compete in materials, one may adopt the other, which straightforwardly generates topological defects. Of particular interest are domain walls in charge-, dipole-, and spin-ordered systems, which govern macroscopic properties and important functionality. However, detailed atomic and electro...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11981-5

    authors： Park JW,Cho GY,Lee J,Yeom HW

    更新日期：2019-09-06 00:00:00

  • Early-warning signals for Dansgaard-Oeschger events in a high-resolution ice core record.

    abstract：:The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04881-7

    authors： Boers N

    更新日期：2018-07-02 00:00:00

  • The genomic landscape of pediatric myelodysplastic syndromes.

    abstract：:Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequenci...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01590-5

    authors： Schwartz JR,Ma J,Lamprecht T,Walsh M,Wang S,Bryant V,Song G,Wu G,Easton J,Kesserwan C,Nichols KE,Mullighan CG,Ribeiro RC,Klco JM

    更新日期：2017-11-16 00:00:00

  • δ and φ back-donation in AnIV metallacycles.

    abstract：:In all known examples of metal-ligand (M-L) δ and φ bonds, the metal orbitals are aligned to the ligand orbitals in a "head-to-head" or "side-to-head" fashion. Here, we report two fundamentally new types of M-L δ and φ interactions; "head-to-side" δ and "side-to-side" φ back-bonding, found in complexes of metallacyclo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15197-w

    authors： Kelley MP,Popov IA,Jung J,Batista ER,Yang P

    更新日期：2020-03-25 00:00:00

  • Minimal biomass deposition in banded iron formations inferred from organic matter and clay relationships.

    abstract：:The cycling of iron and organic matter (OM) is thought to have been a major biogeochemical cycle in the early ferruginous oceans which contributed to the deposition of banded iron formations (BIF). However, BIF are deficient in OM, which is postulated to be the result of near-complete oxidation of OM during iron reduc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12975-z

    authors： Dodd MS,Papineau D,Pirajno F,Wan Y,Karhu JA

    更新日期：2019-11-04 00:00:00

  • Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope.

    abstract：:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1135

    authors： Chabria M,Hertig S,Smith ML,Vogel V

    更新日期：2010-01-01 00:00:00

  • Bending rules for animal propulsion.

    abstract：:Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4293

    authors： Lucas KN,Johnson N,Beaulieu WT,Cathcart E,Tirrell G,Colin SP,Gemmell BJ,Dabiri JO,Costello JH

    更新日期：2014-01-01 00:00:00

  • Molecular structure of promoter-bound yeast TFIID.

    abstract：:Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promot...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07096-y

    authors： Kolesnikova O,Ben-Shem A,Luo J,Ranish J,Schultz P,Papai G

    更新日期：2018-11-07 00:00:00

  • Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

    abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06075-7

    authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

    更新日期：2018-09-06 00:00:00

  • YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.

    abstract：:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14293-1

    authors： Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GY

    更新日期：2020-01-24 00:00:00

  • Adhesive curing through low-voltage activation.

    abstract：:Instant curing adhesives typically fall within three categories, being activated by either light (photocuring), heat (thermocuring) or chemical means. These curing strategies limit applications to specific substrates and can only be activated under certain conditions. Here we present the development of an instant curi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9050

    authors： Ping J,Gao F,Chen JL,Webster RD,Steele TW

    更新日期：2015-08-18 00:00:00

  • Low-carbon pathways for the booming express delivery sector in China.

    abstract：:Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20738-4

    authors： Kang P,Song G,Xu M,Miller TR,Wang H,Zhang H,Liu G,Zhou Y,Ren J,Zhong R,Duan H

    更新日期：2021-01-19 00:00:00

  • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.

    abstract：:Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins level...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11934

    authors： Iturria-Medina Y,Sotero RC,Toussaint PJ,Mateos-Pérez JM,Evans AC,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期：2016-06-21 00:00:00

  • Demographic routes to variability and regulation in bird populations.

    abstract：:There is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environme...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12001

    authors： Sæther BE,Grøtan V,Engen S,Coulson T,Grant PR,Visser ME,Brommer JE,Rosemary Grant B,Gustafsson L,Hatchwell BJ,Jerstad K,Karell P,Pietiäinen H,Roulin A,Røstad OW,Weimerskirch H

    更新日期：2016-06-22 00:00:00

  • An asymmetric heterodomain interface stabilizes a response regulator-DNA complex.

    abstract：:Two-component signal transduction systems consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to environmental cues. Most activated response regulators regulate transcription by binding tightly to promoter DNA via a phosphorylation-triggered inactive-to-active transition. Th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4282

    authors： Narayanan A,Kumar S,Evrard AN,Paul LN,Yernool DA

    更新日期：2014-01-01 00:00:00

  • CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.

    abstract：:Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9972

    authors： Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C

    更新日期：2015-12-03 00:00:00

  • Crosstalk in concurrent repeated games impedes direct reciprocity and requires stronger levels of forgiveness.

    abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02721-8

    authors： Reiter JG,Hilbe C,Rand DG,Chatterjee K,Nowak MA

    更新日期：2018-02-07 00:00:00

  • A framework to predict the price of energy for the end-users with applications to monetary and energy policies.

    abstract：:Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20203-2

    authors： Baratsas SG,Niziolek AM,Onel O,Matthews LR,Floudas CA,Hallermann DR,Sorescu SM,Pistikopoulos EN

    更新日期：2021-01-04 00:00:00

  • In vivo assessment of human brain oscillations during application of transcranial electric currents.

    abstract：:Brain oscillations reflect pattern formation of cell assemblies' activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficia...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3032

    authors： Soekadar SR,Witkowski M,Cossio EG,Birbaumer N,Robinson SE,Cohen LG

    更新日期：2013-01-01 00:00:00

  • Pseudo-topotactic conversion of carbon nanotubes to T-carbon nanowires under picosecond laser irradiation in methanol.

    abstract：:Pseudo-topotactic conversion of carbon nanotubes into one-dimensional carbon nanowires is a challenging but feasible path to obtain desired diameters and morphologies. Here, a previously predicted but experimentally unobserved carbon allotrope, T-carbon, has been produced from pseudo-topotactic conversion of a multi-w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00817-9

    authors： Zhang J,Wang R,Zhu X,Pan A,Han C,Li X,Dan Zhao,Ma C,Wang W,Su H,Niu C

    更新日期：2017-09-25 00:00:00

  • Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.

    abstract：:Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6005

    authors： Chanrion M,Kuperstein I,Barrière C,El Marjou F,Cohen D,Vignjevic D,Stimmer L,Paul-Gilloteaux P,Bièche I,Tavares Sdos R,Boccia GF,Cacheux W,Meseure D,Fre S,Martignetti L,Legoix-Né P,Girard E,Fetler L,Barillot E,Louva

    更新日期：2014-10-08 00:00:00

  • Global urban expansion offsets climate-driven increases in terrestrial net primary productivity.

    abstract：:The global urbanization rate is accelerating; however, data limitations have far prevented robust estimations of either global urban expansion or its effects on terrestrial net primary productivity (NPP). Here, using a high resolution dataset of global land use/cover (GlobeLand30), we show that global urban areas expa...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13462-1

    authors： Liu X,Pei F,Wen Y,Li X,Wang S,Wu C,Cai Y,Wu J,Chen J,Feng K,Liu J,Hubacek K,Davis SJ,Yuan W,Yu L,Liu Z

    更新日期：2019-12-05 00:00:00

  • Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.

    abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14830

    authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

    更新日期：2017-04-03 00:00:00

  • Publisher Correction: Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

    abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20006-5. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-20006-5

    authors： Escalera-Zamudio M,Golden M,Gutiérrez B,Thézé J,Keown JR,Carrique L,Bowden TA,Pybus OG

    更新日期：2020-11-23 00:00:00

  • Limited dissemination of the wastewater treatment plant core resistome.

    abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9452

    authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

    更新日期：2015-09-30 00:00:00