Abstract:
:Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced scattering of near-infrared guide stars. The method enables in vivo two-photon morphological and functional imaging down to 700 μm inside the mouse brain.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang K,Sun W,Richie CT,Harvey BK,Betzig E,Ji Ndoi
10.1038/ncomms8276subject
Has Abstractpub_date
2015-06-15 00:00:00pages
7276issn
2041-1723pii
ncomms8276journal_volume
6pub_type
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