The transferability of lipid loci across African, Asian and European cohorts.

abstract：:Stacking faults are known as defective structures in crystalline materials that typically lower the structural quality of the material. Here, we show that a particular type of defect, that is, stacking fault tetrahedra (SFTs), exhibits pronounced quantized electronic behaviour, revealing a potential synthetic route to...

journal_title：Nature communications

authors： Schouteden K,Amin-Ahmadi B,Li Z,Muzychenko D,Schryvers D,Van Haesendonck C

更新日期：2016-12-23 00:00:00

abstract：:How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and ...

journal_title：Nature communications

authors： Wang S,Drummond ML,Guerrero-Juarez CF,Tarapore E,MacLean AL,Stabell AR,Wu SC,Gutierrez G,That BT,Benavente CA,Nie Q,Atwood SX

更新日期：2020-08-25 00:00:00

abstract：:Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To...

journal_title：Nature communications

authors： D'Amato AR,Puhl DL,Ellman SAT,Balouch B,Gilbert RJ,Palermo EF

更新日期：2019-10-23 00:00:00

abstract：:The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...

journal_title：Nature communications

authors： Mihnev MT,Kadi F,Divin CJ,Winzer T,Lee S,Liu CH,Zhong Z,Berger C,de Heer WA,Malic E,Knorr A,Norris TB

更新日期：2016-05-25 00:00:00

abstract：:Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a ta...

journal_title：Nature communications

authors： Schneider GF,Xu Q,Hage S,Luik S,Spoor JN,Malladi S,Zandbergen H,Dekker C

更新日期：2013-01-01 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:Black silicon is a synthetic nanomaterial that contains high aspect ratio nanoprotrusions on its surface, produced through a simple reactive-ion etching technique for use in photovoltaic applications. Surfaces with high aspect-ratio nanofeatures are also common in the natural world, for example, the wings of the drago...

journal_title：Nature communications

authors： Ivanova EP,Hasan J,Webb HK,Gervinskas G,Juodkazis S,Truong VK,Wu AH,Lamb RN,Baulin VA,Watson GS,Watson JA,Mainwaring DE,Crawford RJ

更新日期：2013-01-01 00:00:00

abstract：:Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing c...

journal_title：Nature communications

authors： Watson SA,Duff J,Bardi I,Zabielska M,Atanur SS,Jabbour RJ,Simon A,Tomas A,Smolenski RT,Harding SE,Perbellini F,Terracciano CM

更新日期：2019-05-15 00:00:00

abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

journal_title：Nature communications

authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

更新日期：2016-08-17 00:00:00

abstract：:The core of a ferromagnetic vortex domain creates a strong, localized magnetic field, which can be manipulated on nanosecond timescales, providing a platform for addressing and controlling individual nitrogen-vacancy centre spins in diamond at room temperature, with nanometre-scale resolution. Here, we show that the f...

journal_title：Nature communications

authors： Wolf MS,Badea R,Berezovsky J

更新日期：2016-06-14 00:00:00

abstract：:Covalently locking interacting proteins in situ is an attractive strategy for addressing the challenge of identifying weak and transient protein interactions, yet it is demanding to execute chemical reactions in live systems in a biocompatible, specific, and autonomous manner. Harnessing proximity-enabled reactivity o...

journal_title：Nature communications

authors： Yang B,Tang S,Ma C,Li ST,Shao GC,Dang B,DeGrado WF,Dong MQ,Wang PG,Ding S,Wang L

更新日期：2017-12-21 00:00:00

abstract：:As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 3...

journal_title：Nature communications

authors： Christidis N,McCarthy M,Stott PA

更新日期：2020-06-30 00:00:00

abstract：:The turnover of messenger RNAs (mRNAs) is a key regulatory step of gene expression in eukaryotic cells. Due to the complexity of the mammalian degradation machinery, the contribution of decay factors to the directionality of mRNA decay is poorly understood. Here we characterize a molecular tool to interrogate mRNA tur...

journal_title：Nature communications

authors： Boehm V,Gerbracht JV,Marx MC,Gehring NH

更新日期：2016-12-05 00:00:00

abstract：:CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing u...

journal_title：Nature communications

authors： Cullot G,Boutin J,Toutain J,Prat F,Pennamen P,Rooryck C,Teichmann M,Rousseau E,Lamrissi-Garcia I,Guyonnet-Duperat V,Bibeyran A,Lalanne M,Prouzet-Mauléon V,Turcq B,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,

更新日期：2019-03-08 00:00:00

abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...

journal_title：Nature communications

authors： Qiu P

更新日期：2020-03-03 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:In the nervous system, A→I RNA editing has an important role in regulating neuronal excitability. Ligand-gated membrane receptors, synaptic proteins, as well as ion channels, are targets for recoding by RNA editing. Although scores of editing sites have been identified in the mammalian brain, little is known about the...

journal_title：Nature communications

authors： Gonzalez C,Lopez-Rodriguez A,Srikumar D,Rosenthal JJ,Holmgren M

更新日期：2011-08-16 00:00:00

abstract：:Ever since the discovery of dye self-assemblies in nature, there have been tremendous efforts to exploit biomimetic supramolecular assemblies for tailored artificial photon processing materials. This feature necessarily has resulted in an increasing demand for understanding exciton dynamics in the dye self-assemblies....

journal_title：Nature communications

authors： Sung J,Kim P,Fimmel B,Würthner F,Kim D

更新日期：2015-10-23 00:00:00

abstract：:Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...

journal_title：Nature communications

authors： Vermulst M,Denney AS,Lang MJ,Hung CW,Moore S,Moseley MA,Thompson JW,Madden V,Gauer J,Wolfe KJ,Summers DW,Schleit J,Sutphin GL,Haroon S,Holczbauer A,Caine J,Jorgenson J,Cyr D,Kaeberlein M,Strathern JN,Duncan MC,E

更新日期：2015-08-25 00:00:00

abstract：:It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...

journal_title：Nature communications

authors： Bisi S,Marchesi S,Rizvi A,Carra D,Beznoussenko GV,Ferrara I,Deflorian G,Mironov A,Bertalot G,Pisati F,Oldani A,Cattaneo A,Saberamoli G,Pece S,Viale G,Bachi A,Tripodo C,Scita G,Disanza A

更新日期：2020-07-14 00:00:00

abstract：:Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...

journal_title：Nature communications

authors： Shostak K,Jiang Z,Charloteaux B,Mayer A,Habraken Y,Tharun L,Klein S,Xu X,Duong HQ,Vislovukh A,Close P,Florin A,Rambow F,Marine JC,Büttner R,Chariot A

更新日期：2020-03-09 00:00:00

abstract：:Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an un...

journal_title：Nature communications

authors： Pawlowski AC,Wang W,Koteva K,Barton HA,McArthur AG,Wright GD

更新日期：2016-12-08 00:00:00

abstract：:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

journal_title：Nature communications

authors： Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

更新日期：2014-06-26 00:00:00

abstract：:There is a multi-billion dollar global industry dedicated to feeding wild birds in residential gardens. This extraordinary boost to food resources is almost certainly reshaping entire bird communities, yet the large-scale, long-term impacts on community ecology remain unknown. Here we reveal a 40-year transformation o...

journal_title：Nature communications

authors： Plummer KE,Risely K,Toms MP,Siriwardena GM

更新日期：2019-05-21 00:00:00

abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

journal_title：Nature communications

authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

更新日期：2020-09-29 00:00:00

abstract：:Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...

journal_title：Nature communications

authors： Mouthuy PO,Coulombier M,Pardoen T,Raskin JP,Jonas AM

更新日期：2012-01-01 00:00:00

abstract：:Many porous materials are damaged by pressure exerted by salt crystals growing in their pores. This is a serious issue in conservation science, geomorphology, geotechnical engineering and concrete materials science. In all cases, a central question is whether crystallization pressure will cause damage. Here we present...

journal_title：Nature communications

authors： Flatt RJ,Caruso F,Sanchez AM,Scherer GW

更新日期：2014-09-11 00:00:00

abstract：:The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of microRNAs. On Nrf2 activation, expression of miR-29a and miR-29b increases in cultured human keratinocytes an...

journal_title：Nature communications

authors： Kurinna S,Schäfer M,Ostano P,Karouzakis E,Chiorino G,Bloch W,Bachmann A,Gay S,Garrod D,Lefort K,Dotto GP,Beer HD,Werner S

更新日期：2014-10-06 00:00:00

abstract：:Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-de...

journal_title：Nature communications

authors： Gannon HS,Zou T,Kiessling MK,Gao GF,Cai D,Choi PS,Ivan AP,Buchumenski I,Berger AC,Goldstein JT,Cherniack AD,Vazquez F,Tsherniak A,Levanon EY,Hahn WC,Meyerson M

更新日期：2018-12-21 00:00:00

abstract：:DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the...

journal_title：Nature communications

authors： Liu J,Zhu Y,Luo GZ,Wang X,Yue Y,Wang X,Zong X,Chen K,Yin H,Fu Y,Han D,Wang Y,Chen D,He C

更新日期：2016-10-07 00:00:00