Abstract：
:CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10 (Th1/Th17), is dependent on the presence of pertussis toxin (PTX) at the time of immunization. PTX induces early production of IL-1β by CD11b(+)CCR2(+)Gr1(+) myeloid cells, which are rapidly recruited to antigen-draining lymph nodes. PTX-induced generation of Th1/Th17 cells is impaired in IL-1β- and ASC-deficient mice and in mice in which myeloid cells are depleted or fail to migrate to lymph nodes and requires expression of IL-1R1 and MyD88 on both T cells and non-T cells. Collectively, these data shed light on the enigmatic function of PTX in EAE induction and suggest that inflammatory monocytes and microbial infection can influence differentiation of pathogenic Th1/Th17 cells in autoimmune diseases through production of IL-1β.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ronchi F,Basso C,Preite S,Reboldi A,Baumjohann D,Perlini L,Lanzavecchia A,Sallusto Fdoi
10.1038/ncomms11541subject
Has Abstractpub_date
2016-05-18 00:00:00pages
11541issn
2041-1723pii
ncomms11541journal_volume
7pub_type
杂志文章abstract：:Anion-π interactions occur on the surface of π-acidic aromatic planes with positive quadrupole moments. Their ability to contribute to the binding and transport of anions has been demonstrated recently. However, their ability to stabilize anionic reactive intermediates and transition states remains essentially unexplo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4911
更新日期：2014-05-21 00:00:00
abstract：:In nature, protein subunits on the capsids of many icosahedral viruses form rotational patterns, and mathematicians also incorporate asymmetric patterns into faces of polyhedra. Chemists have constructed molecular polyhedra with vacant or highly symmetric faces, but very little is known about constructing polyhedra wi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12469
更新日期：2016-08-24 00:00:00
abstract：:In fragmented forests, tree diversity declines near edges but the ecological processes underlying this loss of diversity remain poorly understood. Theory predicts that top-down regulation of seedling recruitment by insect herbivores and fungal pathogens contributes to maintaining tree diversity in forests, but it is u...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06997-2
更新日期：2018-10-30 00:00:00
abstract：:In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobili...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00757-4
更新日期：2017-09-22 00:00:00
abstract：:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10489
更新日期：2016-02-04 00:00:00
abstract：:One key route for controlling reaction selectivity in heterogeneous catalysis is to prepare catalysts that exhibit only specific types of sites required for desired product formation. Here we show that alkanethiolate self-assembled monolayers with varying surface densities can be used to tune selectivity to desired hy...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3448
更新日期：2013-01-01 00:00:00
abstract：:Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15472-w
更新日期：2020-05-08 00:00:00
abstract：:One primary reason that makes single-cell RNA-seq analysis challenging is dropouts, where the data only captures a small fraction of the transcriptome of each cell. Almost all computational algorithms developed for single-cell RNA-seq adopted gene selection, dimension reduction or imputation to address the dropouts. H...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14976-9
更新日期：2020-03-03 00:00:00
abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05154-z
更新日期：2018-07-19 00:00:00
abstract：:Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19379-4
更新日期：2020-11-06 00:00:00
abstract：:How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13329-5
更新日期：2019-12-03 00:00:00
abstract：:Liquid crystalline phases of matter permeate nature and technology, with examples ranging from cell membranes to liquid-crystal displays. Remarkably, electronic liquid-crystal phases can exist in two-dimensional electron systems (2DES) at half Landau-level filling in the quantum Hall regime. Theory has predicted the e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01810-y
更新日期：2017-11-16 00:00:00
abstract：:The space charge layer (SCL) is generally considered one of the origins of the sluggish interfacial lithium-ion transport in all-solid-state lithium-ion batteries (ASSLIBs). However, in-situ visualization of the SCL effect on the interfacial lithium-ion transport in sulfide-based ASSLIBs is still a great challenge. He...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19726-5
更新日期：2020-11-18 00:00:00
abstract：:Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6588
更新日期：2014-11-27 00:00:00
abstract：:Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of substrate compliance in live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through in situ modulation of tissue biomechanics. By first establishing, via high-resolution Brillou...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09331-6
更新日期：2019-04-03 00:00:00
abstract：:There is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environme...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12001
更新日期：2016-06-22 00:00:00
abstract：:After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischem...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13324-w
更新日期：2019-11-22 00:00:00
abstract：:Carbon coating is a simple, effective and common technique for improving the conductivity of active materials in lithium ion batteries. However, carbon coating provides a strong reducing atmosphere and many factors remain unclear concerning the interface nature and underlying interaction mechanism that occurs between ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4415
更新日期：2014-03-05 00:00:00
abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-04164-1
更新日期：2018-05-01 00:00:00
abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01025-1
更新日期：2017-10-24 00:00:00
abstract：:Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02489-x
更新日期：2018-01-09 00:00:00
abstract：:Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16715-6
更新日期：2020-06-05 00:00:00
abstract：:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03001-9
更新日期：2018-02-12 00:00:00
abstract：:COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymph...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17240-2
更新日期：2020-07-08 00:00:00
abstract：:Spin-orbit torque has recently been intensively investigated for the purposes of manipulating the magnetization in magnetic nano-devices and understanding fundamental physics. Therefore, the search for novel materials or material combinations that exhibit a strong enough spin-torque effect has become one of the top pr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06518-1
更新日期：2018-09-28 00:00:00
abstract：:The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09183-0
更新日期：2019-03-18 00:00:00
abstract：:Gate operations in a quantum information processor are generally realized by tailoring specific periods of free and driven evolution of a quantum system. Unwanted environmental noise, which may in principle be distinct during these two periods, acts to decohere the system and increase the gate error rate. Although the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3337
更新日期：2013-01-01 00:00:00
abstract：:Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their s...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19796-5
更新日期：2020-11-23 00:00:00
abstract：:The realization of low-cost photodetectors with high sensitivity, high quantum efficiency, high gain and fast photoresponse in the visible and short-wave infrared remains one of the challenges in optoelectronics. Two classes of photodetectors that have been developed are photodiodes and phototransistors, each of them ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11954
更新日期：2016-06-17 00:00:00
abstract：:Charge transfer states play a crucial role in organic photovoltaics, mediating both photocurrent generation and recombination losses. In this work, we examine recombination losses as a function of the electron-hole spacing in fluorescent charge transfer states, including direct monitoring of both singlet and triplet c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7415
更新日期：2015-03-12 00:00:00
