Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior.

abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...

journal_title：Nature communications

authors： Delaneau O,Zagury JF,Robinson MR,Marchini JL,Dermitzakis ET

更新日期：2019-11-28 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored t...

journal_title：Nature communications

authors： Fornia L,Puglisi G,Leonetti A,Bello L,Berti A,Cerri G,Garbarini F

更新日期：2020-02-04 00:00:00

abstract：:The divalent carbene carbon centre in cyclic (alkyl)(amino)carbenes (CAACs) is known to exhibit transition-metal-like insertion into E-H σ-bonds (E = H, N, Si, B, P, C, O) with formation of new, strong C-E and C-H bonds. Although subsequent transformations of the products represent an attractive strategy for metal-fre...

journal_title：Nature communications

authors： Oldroyd NL,Chitnis SS,Annibale VT,Arz MI,Sparkes HA,Manners I

更新日期：2019-03-26 00:00:00

abstract：:Molecular photoswitches provide an extremely simple solution for solar energy conversion and storage. To convert stored energy to electricity, however, the photoswitch has to be coupled to a semiconducting electrode. In this work, we report on the assembly of an operational solar-energy-storing organic-oxide hybrid in...

journal_title：Nature communications

authors： Schuschke C,Hohner C,Jevric M,Ugleholdt Petersen A,Wang Z,Schwarz M,Kettner M,Waidhas F,Fromm L,Sumby CJ,Görling A,Brummel O,Moth-Poulsen K,Libuda J

更新日期：2019-06-03 00:00:00

abstract：:Fourier ring correlation (FRC) has recently gained popularity among fluorescence microscopists as a straightforward and objective method to measure the effective image resolution. While the knowledge of the numeric resolution value is helpful in e.g., interpreting imaging results, much more practical use can be made o...

journal_title：Nature communications

authors： Koho S,Tortarolo G,Castello M,Deguchi T,Diaspro A,Vicidomini G

更新日期：2019-07-15 00:00:00

abstract：:The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...

journal_title：Nature communications

authors： Li YX,Zhong Z,Zhang WP,Qian PY

更新日期：2018-08-16 00:00:00

abstract：:Electric fields at interfaces exhibit useful phenomena, such as switching functions in transistors, through electron accumulations and/or electric dipole inductions. We find one potentially unique situation in a metal-dielectric interface in which the electric field is atomically inhomogeneous because of the strong el...

journal_title：Nature communications

authors： Miwa S,Suzuki M,Tsujikawa M,Matsuda K,Nozaki T,Tanaka K,Tsukahara T,Nawaoka K,Goto M,Kotani Y,Ohkubo T,Bonell F,Tamura E,Hono K,Nakamura T,Shirai M,Yuasa S,Suzuki Y

更新日期：2017-06-23 00:00:00

abstract：:6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusi...

journal_title：Nature communications

authors： Liu R,Li W,Tao B,Wang X,Yang Z,Zhang Y,Wang C,Liu R,Gao H,Liang J,Yang W

更新日期：2019-03-01 00:00:00

abstract：:Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. Here we establish a Förster resonance energy transfer (FRET) sensor, named CliF, which reports intermolecular associations of...

journal_title：Nature communications

authors： Ma Y,Pandzic E,Nicovich PR,Yamamoto Y,Kwiatek J,Pageon SV,Benda A,Rossy J,Gaus K

更新日期：2017-04-28 00:00:00

abstract：:Current machine learning classifiers have successfully been applied to whole-genome sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they lack causal interpretation. Here we present a metabolic model-based machine learning classifier, named Metabolic Allele Classifier (MAC), that...

journal_title：Nature communications

authors： Kavvas ES,Yang L,Monk JM,Heckmann D,Palsson BO

更新日期：2020-05-22 00:00:00

abstract：:Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into th...

journal_title：Nature communications

authors： Damman R,Schütz S,Luo Y,Weingarth M,Sprangers R,Baldus M

更新日期：2019-10-04 00:00:00

abstract：:Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with follow-up in 10,091 subjects of European and East-Asian descent, we found a new BMD locus that harbours the PTCH1 gene, represented by rs2837...

journal_title：Nature communications

authors： Styrkarsdottir U,Thorleifsson G,Gudjonsson SA,Sigurdsson A,Center JR,Lee SH,Nguyen TV,Kwok TCY,Lee JSW,Ho SC,Woo J,Leung PC,Kim BJ,Rafnar T,Kiemeney LA,Ingvarsson T,Koh JM,Tang NLS,Eisman JA,Christiansen C,Sigurds

更新日期：2016-01-06 00:00:00

abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

journal_title：Nature communications

authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

更新日期：2018-04-18 00:00:00

abstract：:The mammalian neocortex is subdivided into cytoarchitectural areas with distinct connectivity, gene expression and neural functions. Areal identity is initially specified by rostrocaudal and mediolateral gene expression gradients in neuroepithelial and radial glial progenitors (the 'protomap'). On further differentiat...

journal_title：Nature communications

authors： Alfano C,Magrinelli E,Harb K,Hevner RF,Studer M

更新日期：2014-12-05 00:00:00

abstract：:T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR co...

journal_title：Nature communications

authors： Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R

更新日期：2019-05-07 00:00:00

abstract：:The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...

journal_title：Nature communications

authors： Kiga K,Tan XE,Ibarra-Chávez R,Watanabe S,Aiba Y,Sato'o Y,Li FY,Sasahara T,Cui B,Kawauchi M,Boonsiri T,Thitiananpakorn K,Taki Y,Azam AH,Suzuki M,Penadés JR,Cui L

更新日期：2020-06-10 00:00:00

abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

journal_title：Nature communications

authors： Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

更新日期：2020-09-22 00:00:00

abstract：:The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-04-18 00:00:00

abstract：:Converting and storing solar energy and releasing it on demand by using solar flow batteries (SFBs) is a promising way to address the challenge of solar intermittency. Although high solar-to-output electricity efficiencies (SOEE) have been recently demonstrated in SFBs, the complex multi-junction photoelectrodes used ...

journal_title：Nature communications

authors： Fu HC,Li W,Yang Y,Lin CH,Veyssal A,He JH,Jin S

更新日期：2021-01-08 00:00:00

abstract：:Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate tha...

journal_title：Nature communications

authors： Dimitrov M,Alattia JR,Lemmin T,Lehal R,Fligier A,Houacine J,Hussain I,Radtke F,Dal Peraro M,Beher D,Fraering PC

更新日期：2013-01-01 00:00:00

abstract：:As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

journal_title：Nature communications

authors： Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

更新日期：2016-09-01 00:00:00

abstract：:The fields of soft polymers and macromolecular sciences have enjoyed a unique combination of metals and organic frameworks in the name of metallopolymers or organometallic polymers. When metallopolymers carry charged groups, they form a class of metal-containing polyelectrolytes or metallo-polyelectrolytes. This revie...

journal_title：Nature communications

authors： Zhu T,Sha Y,Yan J,Pageni P,Rahman MA,Yan Y,Tang C

更新日期：2018-10-18 00:00:00

abstract：:Development of on-chip integrated carbon-based optoelectronic nanocircuits requires fast and non-invasive structural characterization of their building blocks. Recent advances in synthesis of single wall carbon nanotubes and graphene nanoribbons allow for their use as atomically precise building blocks. However, while...

journal_title：Nature communications

authors： Payod RB,Grassano D,Santos GNC,Levshov DI,Pulci O,Saroka VA

更新日期：2020-01-03 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...

journal_title：Nature communications

authors： Yasumizu Y,Rajabi H,Jin C,Hata T,Pitroda S,Long MD,Hagiwara M,Li W,Hu Q,Liu S,Yamashita N,Fushimi A,Kui L,Samur M,Yamamoto M,Zhang Y,Zhang N,Hong D,Maeda T,Kosaka T,Wong KK,Oya M,Kufe D

更新日期：2020-01-17 00:00:00

abstract：:When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, a...

journal_title：Nature communications

authors： Bein O,Duncan K,Davachi L

更新日期：2020-07-10 00:00:00

abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

journal_title：Nature communications

authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

更新日期：2019-08-16 00:00:00

abstract：:Although the changes in melting behaviour on the nanoscale have long attracted the interest of researchers, the mechanism by which nanoparticles melt remains an open problem. We report the direct observation, at atomic resolution, of surface melting in individual size-selected Au clusters (2-5 nm diameter) supported o...

journal_title：Nature communications

authors： Foster DM,Pavloudis T,Kioseoglou J,Palmer RE

更新日期：2019-06-13 00:00:00

abstract：:Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...

journal_title：Nature communications

authors： Ebo JS,Saunders JC,Devine PWA,Gordon AM,Warwick AS,Schiffrin B,Chin SE,England E,Button JD,Lloyd C,Bond NJ,Ashcroft AE,Radford SE,Lowe DC,Brockwell DJ

更新日期：2020-04-14 00:00:00

abstract：:Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or epigenetic therapies. Here, we evaluate the potential for T cell recognition of HERV element...

journal_title：Nature communications

authors： Saini SK,Ørskov AD,Bjerregaard AM,Unnikrishnan A,Holmberg-Thydén S,Borch A,Jensen KV,Anande G,Bentzen AK,Marquard AM,Tamhane T,Treppendahl MB,Gang AO,Dufva IH,Szallasi Z,Ternette N,Pedersen AG,Eklund AC,Pimanda J,Gr

更新日期：2020-11-09 00:00:00