Abstract：
:Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals, who were matched for body mass index (BMI). TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. Upon high-fat diet feeding, transgenic mice overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display greater proliferation, consistent with elevated adipogenesis. In Tnmd transgenic mice, lipogenic genes are upregulated in eWAT, as is Ucp1 in brown fat, while liver triglyceride accumulation is attenuated. Despite expanded eWAT, transgenic animals display improved systemic insulin sensitivity, decreased collagen deposition and inflammation in eWAT, and increased insulin stimulation of Akt phosphorylation. Our data suggest that TNMD acts as a protective factor in visceral adipose tissue to alleviate insulin resistance in obesity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MPdoi
10.1038/ncomms10686subject
Has Abstractpub_date
2016-02-16 00:00:00pages
10686issn
2041-1723pii
ncomms10686journal_volume
7pub_type
杂志文章abstract：:Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates of USP14 remain largely unknown, hindering the understanding of its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07185-y
更新日期：2018-11-13 00:00:00
abstract：:In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7843
更新日期：2015-04-16 00:00:00
abstract：:Dehydration reactions proceed readily in water-filled biological cells. Development of biocatalysts that mimic such compartmentalized reactions has been cumbersome due to the lack of low-cost nanomaterials and associated technologies. Here we show that cationic lignin nanospheres function as activating anchors for hyd...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04715-6
更新日期：2018-06-12 00:00:00
abstract：:Submarine channels are ubiquitous on the seafloor and their inception and evolution is a result of dynamic interaction between turbidity currents and the evolving seafloor. However, the morphodynamic links between channel inception and flow dynamics have not yet been monitored in experiments and only in one instance o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10886
更新日期：2016-03-21 00:00:00
abstract：:Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12099-4
更新日期：2019-09-12 00:00:00
abstract：:In the original version of this Article, the Acknowledgement section omitted financial support from the Deutsche Forschungsgemeinschaft grant SFB 958/A4. This error has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-03452-0
更新日期：2018-03-09 00:00:00
abstract：:Grain rotation is a well-known phenomenon during high (homologous) temperature deformation and recrystallization of polycrystalline materials. In recent years, grain rotation has also been proposed as a plasticity mechanism at low temperatures (for example, room temperature for metals), especially for nanocrystalline ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5402
更新日期：2014-07-17 00:00:00
abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11039-6
更新日期：2019-07-10 00:00:00
abstract：:The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4487
更新日期：2014-03-19 00:00:00
abstract：:Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explaine...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08593-4
更新日期：2019-02-08 00:00:00
abstract：:Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse. However, gene targeting in higher plants, including the most widely used model plant Arabidopsis thaliana, remains ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04416-0
更新日期：2018-05-17 00:00:00
abstract：:A primary function of the midbrain stimulus selection network is to compute the highest-priority location for attention and gaze. Here we report the contribution of a specific cholinergic circuit to this computation. We functionally disconnected the tegmental cholinergic nucleus isthmi pars parvocellularis (Ipc) from ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13472
更新日期：2016-11-17 00:00:00
abstract：:Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cell...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-14219-6
更新日期：2020-01-17 00:00:00
abstract：:Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CR...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07309-4
更新日期：2018-11-26 00:00:00
abstract：:The growth of atomically dispersed metal catalysts (ADMCs) remains a great challenge owing to the thermodynamically driven atom aggregation. Here we report a surface-limited electrodeposition technique that uses site-specific substrates for the rapid and room-temperature synthesis of ADMCs. We obtained ADMCs by the un...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18430-8
更新日期：2020-09-11 00:00:00
abstract：:The costs for solar photovoltaics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and reports around the world have not adequately captured such dramatic decrease. Those costs are projected to decline further in the near future, bringing new prospects for the widespread penetr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16184-x
更新日期：2020-05-19 00:00:00
abstract：:Perovskite solar cells present one of the most prominent photovoltaic technologies, yet their stability, scalability, and engineering at the molecular level remain challenging. We demonstrate a concept of multifunctional molecular modulation of scalable and operationally stable perovskite solar cells that exhibit exce...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06709-w
更新日期：2018-10-26 00:00:00
abstract：:Visualization and exploration of high-dimensional data is a ubiquitous challenge across disciplines. Widely used techniques such as principal component analysis (PCA) aim to identify dominant trends in one dataset. However, in many settings we have datasets collected under different conditions, e.g., a treatment and a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04608-8
更新日期：2018-05-30 00:00:00
abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18300-3
更新日期：2020-09-11 00:00:00
abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12478
更新日期：2016-08-17 00:00:00
abstract：:Preterm infants exhibit different microbiome colonization patterns relative to full-term infants, and it is speculated that the hospital room environment may contribute to infant microbiome development. Here, we present a genome-resolved metagenomic study of microbial genotypes from the gastrointestinal tracts of infa...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02018-w
更新日期：2017-11-27 00:00:00
abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12986
更新日期：2016-10-04 00:00:00
abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12388-y
更新日期：2019-10-03 00:00:00
abstract：:Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Her...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16887-1
更新日期：2020-06-19 00:00:00
abstract：:Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10432-5
更新日期：2019-06-03 00:00:00
abstract：:Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passag...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06610-6
更新日期：2018-10-23 00:00:00
abstract：:Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03604-2
更新日期：2018-03-19 00:00:00
abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-04545-6
更新日期：2018-05-21 00:00:00
abstract：:In 1816, the coldest summer of the past two centuries was observed over northeastern North America and western Europe. This so-called Year Without a Summer (YWAS) has been widely attributed to the 1815 eruption of Indonesia's Mt. Tambora and was concurrent with agricultural failures and famines worldwide. To understan...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01302-z
更新日期：2017-10-31 00:00:00
abstract：:Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial distribution of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13858-z
更新日期：2020-01-07 00:00:00
