Abstract:
:The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this Article, the order of authors within the author list was incorrect. The PRACTICAL consortium was incorrectly listed after Richard S. Houlston and should have been listed after Nora Pashayan. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Went M,Sud A,Försti A,Halvarsson BM,Weinhold N,Kimber S,van Duin M,Thorleifsson G,Holroyd A,Johnson DC,Li N,Orlando G,Law PJ,Ali M,Chen B,Mitchell JS,Gudbjartsson DF,Kuiper R,Stephens OW,Bertsch U,Broderick P,Cadoi
10.1038/s41467-018-08107-8subject
Has Abstractpub_date
2019-01-10 00:00:00pages
213issue
1issn
2041-1723pii
10.1038/s41467-018-08107-8journal_volume
10pub_type
杂志文章,已发布勘误abstract::Reduced-dimensional perovskites are attractive light-emitting materials due to their efficient luminescence, color purity, tunable bandgap, and structural diversity. A major limitation in perovskite light-emitting diodes is their limited operational stability. Here we demonstrate that rapid photodegradation arises fro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13944-2
更新日期:2020-01-10 00:00:00
abstract::Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01297-7
更新日期:2017-11-03 00:00:00
abstract::Gate operations in a quantum information processor are generally realized by tailoring specific periods of free and driven evolution of a quantum system. Unwanted environmental noise, which may in principle be distinct during these two periods, acts to decohere the system and increase the gate error rate. Although the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3337
更新日期:2013-01-01 00:00:00
abstract::Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13328-6
更新日期:2019-12-02 00:00:00
abstract::Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00022-8
更新日期:2017-04-10 00:00:00
abstract::The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1598
更新日期:2011-12-20 00:00:00
abstract::Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4840
更新日期:2014-05-20 00:00:00
abstract::Soil bacterial diversity varies across biomes with potential impacts on soil ecological functioning. Here, we incorporate key factors that affect soil bacterial abundance and diversity across spatial scales into a mechanistic modeling framework considering soil type, carbon inputs and climate towards predicting soil b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13966-w
更新日期:2020-01-08 00:00:00
abstract::Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02634-6
更新日期:2018-01-15 00:00:00
abstract::The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C cooperates with lysosomal TECPR1 to promote the degradation of disease-relat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16689-5
更新日期:2020-06-12 00:00:00
abstract::Ferroelectrics based on proton tautomerism are promising in low-field and above-room-temperature operations. Here seven organic ferroelectric crystals are examined to search for efficient switching of strong spontaneous polarization on proton tautomerism. Solution-grown crystals exhibit strong pinning of ferroelectric...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14426
更新日期:2017-02-16 00:00:00
abstract::Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within a tissue. Here we report that the NMDA receptor controls cell competition of epithelial cells an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16070-6
更新日期:2020-05-06 00:00:00
abstract::CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10517
更新日期:2016-02-04 00:00:00
abstract::Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12959
更新日期:2016-10-03 00:00:00
abstract::Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18726-9
更新日期:2020-10-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13862-3
更新日期:2020-01-14 00:00:00
abstract::CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63-deficient mice recapitulate Seckel syndrome pathology. The attrition of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8676
更新日期:2015-07-09 00:00:00
abstract::Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16715-6
更新日期:2020-06-05 00:00:00
abstract::Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein aggregates from PD...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13564-w
更新日期:2019-12-04 00:00:00
abstract::Various quantum applications can be reduced to estimating expectation values, which are inevitably deviated by operational and environmental errors. Although errors can be tackled by quantum error correction, the overheads are far from being affordable for near-term technologies. To alleviate the detrimental effects o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14376-z
更新日期:2020-01-30 00:00:00
abstract::Coupling between vibrational modes is essential for energy transfer and dissipation in condensed matter. For water, different O-H stretch modes are known to be very strongly coupled both within and between water molecules, leading to ultrafast dissipation and delocalization of vibrational energy. In contrast, the info...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19759-w
更新日期:2020-11-25 00:00:00
abstract::Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12033
更新日期:2016-06-23 00:00:00
abstract::Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of ...
journal_title:Nature communications
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41467-020-16308-3
更新日期:2020-05-21 00:00:00
abstract::In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2406
更新日期:2013-01-01 00:00:00
abstract::Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2311
更新日期:2012-01-01 00:00:00
abstract::Optimal decision-making employs short-term rewards and abstract long-term information based on which of these is deemed relevant. Employing short- vs. long-term information is associated with different learning mechanisms, yet neural evidence showing that these two are dissociable is lacking. Here we demonstrate that ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01703-0
更新日期:2017-11-22 00:00:00
abstract::Hallmarks of criticality, such as power-laws and scale invariance, have been empirically found in cortical-network dynamics and it has been conjectured that operating at criticality entails functional advantages, such as optimal computational capabilities, memory and large dynamical ranges. As critical behaviour requi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3521
更新日期:2013-01-01 00:00:00
abstract::The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20146-8
更新日期:2021-01-11 00:00:00
abstract::Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08690-4
更新日期:2019-02-18 00:00:00
abstract::We study spin transport in a fully hBN encapsulated monolayer-graphene van der Waals heterostructure at room temperature. A top-layer of bilayer-hBN is used as a tunnel barrier for spin-injection and detection in graphene with ferromagnetic cobalt electrodes. We report surprisingly large and bias-induced (differential...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00317-w
更新日期:2017-08-15 00:00:00