A transposable element insertion is associated with an alternative life history strategy.

abstract：:Naturally-occurring thermal materials usually possess specific thermal conductivity (κ), forming a digital set of κ values. Emerging thermal metamaterials have been deployed to realize effective thermal conductivities unattainable in natural materials. However, the effective thermal conductivities of such mixing-based...

journal_title：Nature communications

authors： Xu G,Dong K,Li Y,Li H,Liu K,Li L,Wu J,Qiu CW

更新日期：2020-11-27 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase activity of recepto...

journal_title：Nature communications

authors： Zhang Y,Su SS,Zhao S,Yang Z,Zhong CQ,Chen X,Cai Q,Yang ZH,Huang D,Wu R,Han J

更新日期：2017-02-08 00:00:00

abstract：:Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference...

journal_title：Nature communications

authors： Tung LW,Lu GL,Lee YH,Yu L,Lee HJ,Leishman E,Bradshaw H,Hwang LL,Hung MS,Mackie K,Zimmer A,Chiou LC

更新日期：2016-07-22 00:00:00

abstract：:TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...

journal_title：Nature communications

authors： Xu H,Agalioti T,Zhao J,Steglich B,Wahib R,Vesely MCA,Bielecki P,Bailis W,Jackson R,Perez D,Izbicki J,Licona-Limón P,Kaartinen V,Geginat J,Esplugues E,Tolosa E,Huber S,Flavell RA,Gagliani N

更新日期：2020-07-03 00:00:00

abstract：:Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...

journal_title：Nature communications

authors： Cusack CL,Swahari V,Hampton Henley W,Michael Ramsey J,Deshmukh M

更新日期：2013-01-01 00:00:00

abstract：:We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scannin...

journal_title：Nature communications

authors： Lin L,Hu P,Shi J,Appleton CM,Maslov K,Li L,Zhang R,Wang LV

更新日期：2018-06-15 00:00:00

abstract：:The original version of this Article contained an error in Eq. 1. The arrows between the symbols "T" and "B", and "B" and "T", were written "↔" but should have been "→", and incorrectly read: IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT↔B+IESEEB↔T The correct from of the Eq. 1 is as follows:IEBIC=IEBAC+ISEE+I(e↔h)+IEBICT→B+IESEEB→T...

journal_title：Nature communications

authors： Hoskins BD,Adam GC,Strelcov E,Zhitenev N,Kolmakov A,Strukov DB,McClelland JJ

更新日期：2018-01-24 00:00:00

abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

更新日期：2018-08-02 00:00:00

abstract：:Topologically protected pseudospin transport, analogous to the quantum spin Hall effect, cannot be strictly implemented for photons and in general bosons because of the lack of symmetry-protected pseudospins. Here we show that the required protection can be provided by the real-space topological excitation of an inter...

journal_title：Nature communications

authors： Bleu O,Malpuech G,Solnyshkov DD

更新日期：2018-09-28 00:00:00

abstract：:A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expe...

journal_title：Nature communications

authors： Ok JM,Baek SH,Hoch C,Kremer RK,Park SY,Ji S,Büchner B,Park JH,Hyun SI,Shim JH,Bang Y,Moon EG,Mazin II,Kim JS

更新日期：2017-12-18 00:00:00

abstract：:Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in...

journal_title：Nature communications

authors： Liu B,Yang Y,Qiu Z,Staron M,Hong F,Li Y,Wu S,Li Y,Hao B,Bona R,Han D,Li Z

更新日期：2010-09-21 00:00:00

abstract：:Though miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through a process that involves Drosha to prevent unfavorable splicing and directly ...

journal_title：Nature communications

authors： Profumo V,Forte B,Percio S,Rotundo F,Doldi V,Ferrari E,Fenderico N,Dugo M,Romagnoli D,Benelli M,Valdagni R,Dolfini D,Zaffaroni N,Gandellini P

更新日期：2019-01-18 00:00:00

abstract：:Tomography--cross-sectional imaging based on measuring radiation transmitted through an object along different directions--enables non-invasive imaging of hidden stationary objects, such as internal bodily organs, from their sequentially measured projections. Here we adapt tomographic methods to visualize--in one lase...

journal_title：Nature communications

authors： Li Z,Zgadzaj R,Wang X,Chang YY,Downer MC

更新日期：2014-01-01 00:00:00

abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

journal_title：Nature communications

authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

更新日期：2018-06-06 00:00:00

abstract：:Amplitude modes arising from symmetry breaking in materials are of broad interest in condensed matter physics. These modes reflect an oscillation in the amplitude of a complex order parameter, yet are typically unstable and decay into oscillations of the order parameter's phase. This renders stable amplitude modes rar...

journal_title：Nature communications

authors： Dally RL,Zhao Y,Xu Z,Chisnell R,Stone MB,Lynn JW,Balents L,Wilson SD

更新日期：2018-06-05 00:00:00

abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

journal_title：Nature communications

authors： Zhao K,Bruinsma R,Mason TG

更新日期：2012-05-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in patients with mutat...

journal_title：Nature communications

authors： Persson Ö,Muthukumar Y,Basu S,Jenninger L,Uhler JP,Berglund AK,McFarland R,Taylor RW,Gustafsson CM,Larsson E,Falkenberg M

更新日期：2019-02-15 00:00:00

abstract：:Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...

journal_title：Nature communications

authors： Tschakert J,Zhong Q,Martin-Jimenez D,Carracedo-Cosme J,Romero-Muñiz C,Henkel P,Schlöder T,Ahles S,Mollenhauer D,Wegner HA,Pou P,Pérez R,Schirmeisen A,Ebeling D

更新日期：2020-11-06 00:00:00

abstract：:Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here...

journal_title：Nature communications

authors： Scott LJ,Erdos MR,Huyghe JR,Welch RP,Beck AT,Wolford BN,Chines PS,Didion JP,Narisu N,Stringham HM,Taylor DL,Jackson AU,Vadlamudi S,Bonnycastle LL,Kinnunen L,Saramies J,Sundvall J,Albanus RD,Kiseleva A,Hensley J,Cr

更新日期：2016-06-29 00:00:00

abstract：:Quantum Griffiths singularity was theoretically proposed to interpret the phenomenon of divergent dynamical exponent in quantum phase transitions. It has been discovered experimentally in three-dimensional (3D) magnetic metal systems and two-dimensional (2D) superconductors. But, whether this state exists in lower dim...

journal_title：Nature communications

authors： Zhang E,Zhi J,Zou YC,Ye Z,Ai L,Shi J,Huang C,Liu S,Lin Z,Zheng X,Kang N,Xu H,Wang W,He L,Zou J,Liu J,Mao Z,Xiu F

更新日期：2018-11-07 00:00:00

abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

更新日期：2018-03-13 00:00:00

abstract：:The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...

journal_title：Nature communications

authors： Yu ZP,Liu ZX,Chen FX,Qin R,Lau TK,Yin JL,Kong X,Lu X,Shi M,Li CZ,Chen H

更新日期：2019-05-14 00:00:00

abstract：:Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar and primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure of TRPC4 in its unliganded (...

journal_title：Nature communications

authors： Duan J,Li J,Zeng B,Chen GL,Peng X,Zhang Y,Wang J,Clapham DE,Li Z,Zhang J

更新日期：2018-08-06 00:00:00

abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

journal_title：Nature communications

authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

更新日期：2016-08-17 00:00:00

abstract：:Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...

journal_title：Nature communications

authors： Dushenko S,Hokazono M,Nakamura K,Ando Y,Shinjo T,Shiraishi M

更新日期：2018-08-07 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, on-demand products are currently missing from the PrEP deve...

journal_title：Nature communications

authors： Derby N,Lal M,Aravantinou M,Kizima L,Barnable P,Rodriguez A,Lai M,Wesenberg A,Ugaonkar S,Levendosky K,Mizenina O,Kleinbeck K,Lifson JD,Peet MM,Lloyd Z,Benson M,Heneine W,O'Keefe BR,Robbiani M,Martinelli E,Grasperg

更新日期：2018-09-24 00:00:00

abstract：:Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

journal_title：Nature communications

authors： Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

更新日期：2018-11-22 00:00:00

abstract：:Two-dimensional nanomaterials such as MoS2 are of great interest both because of their novel physical properties and their applications potential. Liquid exfoliation, an important production method, is limited by our inability to quickly and easily measure nanosheet size, thickness or concentration. Here we demonstrat...

journal_title：Nature communications

authors： Backes C,Smith RJ,McEvoy N,Berner NC,McCloskey D,Nerl HC,O'Neill A,King PJ,Higgins T,Hanlon D,Scheuschner N,Maultzsch J,Houben L,Duesberg GS,Donegan JF,Nicolosi V,Coleman JN

更新日期：2014-08-07 00:00:00