Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

abstract：:Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reprod...

journal_title：Nature communications

authors： You Y,Sawikowska A,Neumann M,Posé D,Capovilla G,Langenecker T,Neher RA,Krajewski P,Schmid M

更新日期：2017-05-17 00:00:00

abstract：:Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 coupling complex (T4CC). Here, we purify an intact T4CC from the Legi...

journal_title：Nature communications

authors： Meir A,Macé K,Lukoyanova N,Chetrit D,Hospenthal MK,Redzej A,Roy C,Waksman G

更新日期：2020-06-08 00:00:00

abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

journal_title：Nature communications

authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

更新日期：2021-01-13 00:00:00

abstract：:The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discoverin...

journal_title：Nature communications

authors： Ntalla I,Weng LC,Cartwright JH,Hall AW,Sveinbjornsson G,Tucker NR,Choi SH,Chaffin MD,Roselli C,Barnes MR,Mifsud B,Warren HR,Hayward C,Marten J,Cranley JJ,Concas MP,Gasparini P,Boutin T,Kolcic I,Polasek O,Rudan I,

更新日期：2020-05-21 00:00:00

abstract：:Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...

journal_title：Nature communications

authors： Bittner N,Jockwitz C,Mühleisen TW,Hoffstaedter F,Eickhoff SB,Moebus S,Bayen UJ,Cichon S,Zilles K,Amunts K,Caspers S

更新日期：2019-02-06 00:00:00

abstract：:In the original version of this Article, an additional double-headed arrow was inadvertently included within Fig. 3e. This error has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Gokhale S,Conwill A,Ranjan T,Gore J

更新日期：2019-02-12 00:00:00

abstract：:Two-dimensional metallic transition metal dichalcogenides are emerging as prototypes for uncovering fundamental physical phenomena, such as superconductivity and charge-density waves, as well as for engineering-related applications. However, the batch production of such envisioned transition metal dichalcogenides rema...

journal_title：Nature communications

authors： Shi J,Wang X,Zhang S,Xiao L,Huan Y,Gong Y,Zhang Z,Li Y,Zhou X,Hong M,Fang Q,Zhang Q,Liu X,Gu L,Liu Z,Zhang Y

更新日期：2017-10-16 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15732. ...

journal_title：Nature communications

authors： Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

更新日期：2018-03-12 00:00:00

abstract：:Real-time imaging of moving organs and tissues at microscopic resolutions represents a major challenge in studying the complex biology of live animals. Here we present a technique based on a novel stabilizer setup combined with a gating acquisition algorithm for the imaging of a beating murine heart at the single-cell...

journal_title：Nature communications

authors： Lee S,Vinegoni C,Feruglio PF,Fexon L,Gorbatov R,Pivoravov M,Sbarbati A,Nahrendorf M,Weissleder R

更新日期：2012-01-01 00:00:00

abstract：:The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...

journal_title：Nature communications

authors： Liang W,Yao J,Chen A,Lv Q,Zanin M,Liu J,Wong S,Li Y,Lu J,Liang H,Chen G,Guo H,Guo J,Zhou R,Ou L,Zhou N,Chen H,Yang F,Han X,Huan W,Tang W,Guan W,Chen Z,Zhao Y,Sang L,Xu Y,Wang W,Li S,Lu L,Zhang N

更新日期：2020-07-15 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00

abstract：:Bioluminescent organisms are likely to have an evolutionary drive towards high radiance. As such, bio-optimized materials derived from them hold great promise for photonic applications. Here, we show that biologically produced fluorescent proteins retain their high brightness even at the maximum density in solid state...

journal_title：Nature communications

authors： Gather MC,Yun SH

更新日期：2014-12-08 00:00:00

abstract：:Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...

journal_title：Nature communications

authors： Doster J,Hoenl S,Lorenz H,Paulitschke P,Weig EM

更新日期：2019-11-20 00:00:00

abstract：:NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...

journal_title：Nature communications

authors： Hafner-Bratkovič I,Sušjan P,Lainšček D,Tapia-Abellán A,Cerović K,Kadunc L,Angosto-Bazarra D,Pelegrin P,Jerala R

更新日期：2018-12-05 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the emb...

journal_title：Nature communications

authors： Pineault KM,Song JY,Kozloff KM,Lucas D,Wellik DM

更新日期：2019-07-18 00:00:00

abstract：:The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show that macrophage metabolites are defined in a specific tissue context, and these metabolites are crucially linked to tissue-resident macrophage functions. We find ...

journal_title：Nature communications

authors： Davies LC,Rice CM,Palmieri EM,Taylor PR,Kuhns DB,McVicar DW

更新日期：2017-12-12 00:00:00

abstract：:Quantized dynamics is essential for natural processes and technological applications alike. The work of Thouless on quantized particle transport in slowly varying potentials (Thouless pumping) has played a key role in understanding that such quantization may be caused not only by discrete eigenvalues of a quantum syst...

journal_title：Nature communications

authors： Fedorova Z,Qiu H,Linden S,Kroha J

更新日期：2020-07-27 00:00:00

abstract：:Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...

journal_title：Nature communications

authors： Peysakhovich A,Nowak MA,Rand DG

更新日期：2014-09-16 00:00:00

abstract：:Multiciliated cells (MCCs) harbor dozens to hundreds of motile cilia, which generate hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation involves massive centriole production by poorly characterized structures called deuterosomes. Here, single-cell RNA sequencing reveals that human ...

journal_title：Nature communications

authors： Revinski DR,Zaragosi LE,Boutin C,Ruiz-Garcia S,Deprez M,Thomé V,Rosnet O,Gay AS,Mercey O,Paquet A,Pons N,Ponzio G,Marcet B,Kodjabachian L,Barbry P

更新日期：2018-11-07 00:00:00

abstract：:Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

journal_title：Nature communications

authors： Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

更新日期：2017-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Masid M,Ataman M,Hatzimanikatis V

更新日期：2020-07-23 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked ...

journal_title：Nature communications

authors： Caval V,Suspène R,Shapira M,Vartanian JP,Wain-Hobson S

更新日期：2014-10-09 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural k...

journal_title：Nature communications

authors： Ni F,Sun R,Fu B,Wang F,Guo C,Tian Z,Wei H

更新日期：2013-01-01 00:00:00

abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

journal_title：Nature communications

authors： Grossen C,Guillaume F,Keller LF,Croll D

更新日期：2020-02-21 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood. Here we show that glucocorticoids suppress bacteria...

journal_title：Nature communications

authors： Miyata M,Lee JY,Susuki-Miyata S,Wang WY,Xu H,Kai H,Kobayashi KS,Flavell RA,Li JD

更新日期：2015-01-14 00:00:00

abstract：:As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

journal_title：Nature communications

authors： Davy M,Shi Z,Park J,Tian C,Genack AZ

更新日期：2015-04-20 00:00:00