Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

abstract：:Hydrothermal synthesis is challenging in metal oxide systems with diverse polymorphism, as reaction products are often sensitive to subtle variations in synthesis parameters. This sensitivity is rooted in the non-equilibrium nature of low-temperature crystallization, where competition between different metastable phas...

journal_title：Nature communications

authors： Chen BR,Sun W,Kitchaev DA,Mangum JS,Thampy V,Garten LM,Ginley DS,Gorman BP,Stone KH,Ceder G,Toney MF,Schelhas LT

更新日期：2018-06-29 00:00:00

abstract：:The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service...

journal_title：Nature communications

authors： Della Rossa F,Salzano D,Di Meglio A,De Lellis F,Coraggio M,Calabrese C,Guarino A,Cardona-Rivera R,De Lellis P,Liuzza D,Lo Iudice F,Russo G,di Bernardo M

更新日期：2020-10-09 00:00:00

abstract：:One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...

journal_title：Nature communications

authors： Du X,Dong L,Lan Y,Peng Y,Wu A,Zhang Y,Huang W,Wang D,Wang M,Guo Y,Shu Y,Jiang T

更新日期：2012-02-28 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...

journal_title：Nature communications

authors： Yu X,Feizpour A,Ramirez NG,Wu L,Akiyama H,Xu F,Gummuluru S,Reinhard BM

更新日期：2014-06-20 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of ...

journal_title：Nature communications

authors： Freedman SB,Xie J,Nettel-Aguirre A,Pang XL,Chui L,Williamson-Urquhart S,Schnadower D,Schuh S,Sherman PM,Lee BE,Gouin S,Farion KJ,Poonai N,Hurley KF,Qiu Y,Ghandi B,Lloyd C,Finkelstein Y,Pediatric Emergency Research Can

更新日期：2020-05-21 00:00:00

abstract：:Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation initiation...

journal_title：Nature communications

authors： Barragán-Iglesias P,Lou TF,Bhat VD,Megat S,Burton MD,Price TJ,Campbell ZT

更新日期：2018-01-02 00:00:00

abstract：:Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...

journal_title：Nature communications

authors： Jin L,Feng X,Rong H,Pan Z,Inaba Y,Qiu L,Zheng W,Lin S,Wang R,Wang Z,Wang S,Liu H,Li S,Xie W,Li Y

更新日期：2013-01-01 00:00:00

abstract：:The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...

journal_title：Nature communications

authors： Manjavacas A,García de Abajo FJ

更新日期：2014-03-27 00:00:00

abstract：:Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...

journal_title：Nature communications

authors： Umeshappa CS,Singha S,Blanco J,Shao K,Nanjundappa RH,Yamanouchi J,Parés A,Serra P,Yang Y,Santamaria P

更新日期：2019-05-14 00:00:00

abstract：:Optical phase change materials (O-PCMs), a unique group of materials featuring exceptional optical property contrast upon a solid-state phase transition, have found widespread adoption in photonic applications such as switches, routers and reconfigurable meta-optics. Current O-PCMs, such as Ge-Sb-Te (GST), exhibit lar...

journal_title：Nature communications

authors： Zhang Y,Chou JB,Li J,Li H,Du Q,Yadav A,Zhou S,Shalaginov MY,Fang Z,Zhong H,Roberts C,Robinson P,Bohlin B,Ríos C,Lin H,Kang M,Gu T,Warner J,Liberman V,Richardson K,Hu J

更新日期：2019-09-30 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in th...

journal_title：Nature communications

authors： Ryu JK,Petersen MA,Murray SG,Baeten KM,Meyer-Franke A,Chan JP,Vagena E,Bedard C,Machado MR,Rios Coronado PE,Prod'homme T,Charo IF,Lassmann H,Degen JL,Zamvil SS,Akassoglou K

更新日期：2015-09-10 00:00:00

abstract：:Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex ...

journal_title：Nature communications

authors： Bagot RC,Parise EM,Peña CJ,Zhang HX,Maze I,Chaudhury D,Persaud B,Cachope R,Bolaños-Guzmán CA,Cheer JF,Deisseroth K,Han MH,Nestler EJ

更新日期：2015-05-08 00:00:00

abstract：:A common analysis of single-cell sequencing data includes clustering of cells and identifying differentially expressed genes (DEGs). How cell clusters are defined has important consequences for downstream analyses and the interpretation of results, but is often not straightforward. To address this difficulty, we prese...

journal_title：Nature communications

authors： Vandenbon A,Diez D

更新日期：2020-08-28 00:00:00

abstract：:In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lym...

journal_title：Nature communications

authors： Farinello D,Wozińska M,Lenti E,Genovese L,Bianchessi S,Migliori E,Sacchetti N,di Lillo A,Bertilaccio MTS,de Lalla C,Valsecchi R,Gleave SB,Lligé D,Scielzo C,Mauri L,Ciampa MG,Scarfò L,Bernardi R,Lazarevic D,Gonzalez-

更新日期：2018-05-03 00:00:00

abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

journal_title：Nature communications

authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

更新日期：2020-07-24 00:00:00

abstract：:Twisted Laguerre-Gaussian lasers, with orbital angular momentum and characterized by doughnut-shaped intensity profiles, provide a transformative set of tools and research directions in a growing range of fields and applications, from super-resolution microcopy and ultra-fast optical communications to quantum computin...

journal_title：Nature communications

authors： Vieira J,Trines RM,Alves EP,Fonseca RA,Mendonça JT,Bingham R,Norreys P,Silva LO

更新日期：2016-01-28 00:00:00

abstract：:Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expre...

journal_title：Nature communications

authors： Wei Y,de Lange SC,Scholtens LH,Watanabe K,Ardesch DJ,Jansen PR,Savage JE,Li L,Preuss TM,Rilling JK,Posthuma D,van den Heuvel MP

更新日期：2019-10-24 00:00:00

abstract：:Biological tissues have the remarkable ability to remodel and repair in response to disease, injury and mechanical stresses. Synthetic materials lack the complexity of biological tissues, and man-made materials that respond to external stresses through a permanent increase in stiffness are uncommon. Here we report tha...

journal_title：Nature communications

authors： Agrawal A,Chipara AC,Shamoo Y,Patra PK,Carey BJ,Ajayan PM,Chapman WG,Verduzco R

更新日期：2013-01-01 00:00:00

abstract：:Phase separation of specific biomolecules into liquid droplet-like condensates is a key mechanism to form membrane-less organelles, which spatio-temporally organize diverse biochemical processes in cells. To investigate the working principles of these biomolecular condensates as dynamic reaction centers, precise contr...

journal_title：Nature communications

authors： Hong K,Song D,Jung Y

更新日期：2020-11-03 00:00:00

abstract：:Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxyge...

journal_title：Nature communications

authors： Tzoumas S,Nunes A,Olefir I,Stangl S,Symvoulidis P,Glasl S,Bayer C,Multhoff G,Ntziachristos V

更新日期：2016-06-30 00:00:00

abstract：:Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylatio...

journal_title：Nature communications

authors： Zhou Y,Yamada N,Tanaka T,Hori T,Yokoyama S,Hayakawa Y,Yano S,Fukuoka J,Koizumi K,Saiki I,Sakurai H

更新日期：2015-07-09 00:00:00

abstract：:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine func...

journal_title：Nature communications

authors： Rigoli F,Friston KJ,Dolan RJ

更新日期：2016-08-18 00:00:00

abstract：:COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymph...

journal_title：Nature communications

authors： Song JW,Zhang C,Fan X,Meng FP,Xu Z,Xia P,Cao WJ,Yang T,Dai XP,Wang SY,Xu RN,Jiang TJ,Li WG,Zhang DW,Zhao P,Shi M,Agrati C,Ippolito G,Maeurer M,Zumla A,Wang FS,Zhang JY

更新日期：2020-07-08 00:00:00

abstract：:Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...

journal_title：Nature communications

authors： Zhang L,Zhang X,Tian G,Zhang Q,Knapp M,Ehrenberg H,Chen G,Shen Z,Yang G,Gu L,Du F

更新日期：2020-07-13 00:00:00

abstract：:The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...

journal_title：Nature communications

authors： Santodonato LJ,Zhang Y,Feygenson M,Parish CM,Gao MC,Weber RJ,Neuefeind JC,Tang Z,Liaw PK

更新日期：2015-01-20 00:00:00

abstract：:The manipulation of magnetic ordering with applied electric fields is of pressing interest for new magnetoelectric devices and information storage applications. Recently, such magnetoelectric control was realized in multiferroics. However, their magnetoelectric switching is often accompanied by significant hysteresis,...

journal_title：Nature communications

authors： Oh YS,Artyukhin S,Yang JJ,Zapf V,Kim JW,Vanderbilt D,Cheong SW

更新日期：2014-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： López-Barneo J,Simon MC

更新日期：2020-02-25 00:00:00