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An intrinsic timer specifies distal structures of the vertebrate limb.

Abstract：

:How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the limb are specified is intensely debated. Early work suggested that cells intrinsically change their proximo-distal positional values by measuring time. Recently, however, it is suggested that instructive extrinsic signals from the trunk and apical ectodermal ridge specify the stylopod and zeugopod/autopod, respectively. Here, we show that the zeugopod and autopod are specified by an intrinsic timing mechanism. By grafting green fluorescent protein-expressing cells from early to late chick wing buds, we demonstrate that distal mesenchyme cells intrinsically time Hoxa13 expression, cell cycle parameters and the duration of the overlying apical ectodermal ridge. In addition, we reveal that cell affinities intrinsically change in the distal mesenchyme, which we suggest results in a gradient of positional values along the proximo-distal axis. We propose a complete model in which a switch from extrinsic signalling to intrinsic timing patterns the vertebrate limb.

journal_name

Nat Commun

journal_title

Nature communications

authors

Saiz-Lopez P,Chinnaiya K,Campa VM,Delgado I,Ros MA,Towers M

doi

10.1038/ncomms9108

subject

Has Abstract

pub_date

2015-09-18 00:00:00

pages

8108

issn

2041-1723

pii

ncomms9108

journal_volume

6

pub_type

杂志文章

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