当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses.

The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses.

Abstract：

:Ca2+ coordinates diverse cellular processes, yet how function-specific signals arise is enigmatic. We describe a cell-wide network of distinct cytoplasmic nanocourses with the nucleus at its centre, demarcated by sarcoplasmic reticulum (SR) junctions (≤400 nm across) that restrict Ca2+ diffusion and by nanocourse-specific Ca2+-pumps that facilitate signal segregation. Ryanodine receptor subtype 1 (RyR1) supports relaxation of arterial myocytes by unloading Ca2+ into peripheral nanocourses delimited by plasmalemma-SR junctions, fed by sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b). Conversely, stimulus-specified increases in Ca2+ flux through RyR2/3 clusters selects for rapid propagation of Ca2+ signals throughout deeper extraperinuclear nanocourses and thus myocyte contraction. Nuclear envelope invaginations incorporating SERCA1 in their outer nuclear membranes demarcate further diverse networks of cytoplasmic nanocourses that receive Ca2+ signals through discrete RyR1 clusters, impacting gene expression through epigenetic marks segregated by their associated invaginations. Critically, this circuit is not hardwired and remodels for different outputs during cell proliferation.

journal_name

Nat Commun

journal_title

Nature communications

authors

Duan J,Navarro-Dorado J,Clark JH,Kinnear NP,Meinke P,Schirmer EC,Evans AM

doi

10.1038/s41467-019-10055-w

subject

Has Abstract

pub_date

2019-05-24 00:00:00

pages

2299

issue

1

issn

2041-1723

pii

10.1038/s41467-019-10055-w

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Continuous dynamic adjustment of the plant circadian oscillator.

    abstract：:The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana. The circadian oscillator is an important regulator of much of plant physiology, though many of the mechanisms are unclear. New findings demonstrate that the oscillator adjusts phase and period in response to ...

    journal_title：Nature communications

    pub_type： 杂志文章,评审

    doi：10.1038/s41467-019-08398-5

    authors： Webb AAR,Seki M,Satake A,Caldana C

    更新日期：2019-02-01 00:00:00

  • Primed histone demethylation regulates shoot regenerative competency.

    abstract：:Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09386-5

    authors： Ishihara H,Sugimoto K,Tarr PT,Temman H,Kadokura S,Inui Y,Sakamoto T,Sasaki T,Aida M,Suzuki T,Inagaki S,Morohashi K,Seki M,Kakutani T,Meyerowitz EM,Matsunaga S

    更新日期：2019-04-16 00:00:00

  • Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism.

    abstract：:The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dea...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16796-3

    authors： Singla S,Iwamoto-Stohl LK,Zhu M,Zernicka-Goetz M

    更新日期：2020-06-11 00:00:00

  • Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly.

    abstract：:5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16694-8

    authors： Huang S,Aleksashin NA,Loveland AB,Klepacki D,Reier K,Kefi A,Szal T,Remme J,Jaeger L,Vázquez-Laslop N,Korostelev AA,Mankin AS

    更新日期：2020-06-09 00:00:00

  • Molecular architecture of native fibronectin fibrils.

    abstract：:Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8275

    authors： Früh SM,Schoen I,Ries J,Vogel V

    更新日期：2015-06-04 00:00:00

  • Tornado outbreak variability follows Taylor's power law of fluctuation scaling and increases dramatically with severity.

    abstract：:Tornadoes cause loss of life and damage to property each year in the United States and around the world. The largest impacts come from 'outbreaks' consisting of multiple tornadoes closely spaced in time. Here we find an upward trend in the annual mean number of tornadoes per US tornado outbreak for the period 1954-201...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10668

    authors： Tippett MK,Cohen JE

    更新日期：2016-02-29 00:00:00

  • Magnetotactic bacteria in a droplet self-assemble into a rotary motor.

    abstract：:From intracellular protein trafficking to large-scale motion of animal groups, the physical concepts driving the self-organization of living systems are still largely unraveled. Self-organization of active entities, leading to novel phases and emergent macroscopic properties, recently shed new light on these complex d...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13031-6

    authors： Vincenti B,Ramos G,Cordero ML,Douarche C,Soto R,Clement E

    更新日期：2019-11-08 00:00:00

  • Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through.

    abstract：:The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regul...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9959

    authors： Batista L,Bourachot B,Mateescu B,Reyal F,Mechta-Grigoriou F

    更新日期：2016-01-04 00:00:00

  • Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis.

    abstract：:The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreERT2 lineage-tracing with inducible SMC and pericyte (SMC-P) knockout of Oct4 that Oct4 regulates perivascular cell migration...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08811-z

    authors： Hess DL,Kelly-Goss MR,Cherepanova OA,Nguyen AT,Baylis RA,Tkachenko S,Annex BH,Peirce SM,Owens GK

    更新日期：2019-02-27 00:00:00

  • Mechanical evidence that Australopithecus sediba was limited in its ability to eat hard foods.

    abstract：:Australopithecus sediba has been hypothesized to be a close relative of the genus Homo. Here we show that MH1, the type specimen of A. sediba, was not optimized to produce high molar bite force and appears to have been limited in its ability to consume foods that were mechanically challenging to eat. Dental microwear ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10596

    authors： Ledogar JA,Smith AL,Benazzi S,Weber GW,Spencer MA,Carlson KB,McNulty KP,Dechow PC,Grosse IR,Ross CF,Richmond BG,Wright BW,Wang Q,Byron C,Carlson KJ,de Ruiter DJ,Berger LR,Tamvada K,Pryor LC,Berthaume MA,Strait DS

    更新日期：2016-02-08 00:00:00

  • Mechanisms of increased Trichodesmium fitness under iron and phosphorus co-limitation in the present and future ocean.

    abstract：:Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12081

    authors： Walworth NG,Fu FX,Webb EA,Saito MA,Moran D,Mcllvin MR,Lee MD,Hutchins DA

    更新日期：2016-06-27 00:00:00

  • Electrophysiological dynamics of antagonistic brain networks reflect attentional fluctuations.

    abstract：:Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate the behavioral relevance of fine-grained dynamics within and between these networks. The three n...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14166-2

    authors： Kucyi A,Daitch A,Raccah O,Zhao B,Zhang C,Esterman M,Zeineh M,Halpern CH,Zhang K,Zhang J,Parvizi J

    更新日期：2020-01-16 00:00:00

  • Synthesis and assembly of extended quintulene.

    abstract：:Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17691-7

    authors： Hou H,Zhao XJ,Tang C,Ju YY,Deng ZY,Wang XR,Feng LB,Lin DH,Hou X,Narita A,Müllen K,Tan YZ

    更新日期：2020-08-07 00:00:00

  • Brain-to-cervical lymph node signaling after stroke.

    abstract：:After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13324-w

    authors： Esposito E,Ahn BJ,Shi J,Nakamura Y,Park JH,Mandeville ET,Yu Z,Chan SJ,Desai R,Hayakawa A,Ji X,Lo EH,Hayakawa K

    更新日期：2019-11-22 00:00:00

  • Mesoporous monoliths of inverse bicontinuous cubic phases of block copolymer bilayers.

    abstract：:Solution self-assembly of block copolymers into inverse bicontinuous cubic mesophases is a promising new approach for creating porous polymer films and monoliths with highly organized bicontinuous mesoporous networks. Here we report the direct self-assembly of block copolymers with branched hydrophilic blocks into lar...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7392

    authors： Park C,La Y,An TH,Jeong HY,Kang S,Joo SH,Ahn H,Shin TJ,Kim KT

    更新日期：2015-03-05 00:00:00

  • Self-cleaning and surface chemical reactions during hafnium dioxide atomic layer deposition on indium arsenide.

    abstract：:Atomic layer deposition (ALD) enables the ultrathin high-quality oxide layers that are central to all modern metal-oxide-semiconductor circuits. Crucial to achieving superior device performance are the chemical reactions during the first deposition cycle, which could ultimately result in atomic-scale perfection of the...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03855-z

    authors： Timm R,Head AR,Yngman S,Knutsson JV,Hjort M,McKibbin SR,Troian A,Persson O,Urpelainen S,Knudsen J,Schnadt J,Mikkelsen A

    更新日期：2018-04-12 00:00:00

  • Prothymosin α overexpression contributes to the development of pulmonary emphysema.

    abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2906

    authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

    更新日期：2013-01-01 00:00:00

  • Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module.

    abstract：:Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12277

    authors： Yim N,Ryu SW,Choi K,Lee KR,Lee S,Choi H,Kim J,Shaker MR,Sun W,Park JH,Kim D,Heo WD,Choi C

    更新日期：2016-07-22 00:00:00

  • CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.

    abstract：:CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and correct congenital erythropoietic porphyria. We demonstrate that homology-directed repair is rare compared with NHEJ pathway leading to on-target indels and causing u...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09006-2

    authors： Cullot G,Boutin J,Toutain J,Prat F,Pennamen P,Rooryck C,Teichmann M,Rousseau E,Lamrissi-Garcia I,Guyonnet-Duperat V,Bibeyran A,Lalanne M,Prouzet-Mauléon V,Turcq B,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,

    更新日期：2019-03-08 00:00:00

  • Optical framed knots as information carriers.

    abstract：:Modern beam shaping techniques have enabled the generation of optical fields displaying a wealth of structural features, which include three-dimensional topologies such as Möbius, ribbon strips and knots. However, unlike simpler types of structured light, the topological properties of these optical fields have hithert...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18792-z

    authors： Larocque H,D'Errico A,Ferrer-Garcia MF,Carmi A,Cohen E,Karimi E

    更新日期：2020-10-09 00:00:00

  • Nanoelectromechanical coupling in fullerene peapods probed by resonant electrical transport experiments.

    abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1034

    authors： Utko P,Ferone R,Krive IV,Shekhter RI,Jonson M,Monthioux M,Noé L,Nygård J

    更新日期：2010-07-13 00:00:00

  • Extended anharmonic collapse of phonon dispersions in SnS and SnSe.

    abstract：:The lattice dynamics and high-temperature structural transition in SnS and SnSe are investigated via inelastic neutron scattering, high-resolution Raman spectroscopy and anharmonic first-principles simulations. We uncover a spectacular, extreme softening and reconstruction of an entire manifold of low-energy acoustic ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18121-4

    authors： Lanigan-Atkins T,Yang S,Niedziela JL,Bansal D,May AF,Puretzky AA,Lin JYY,Pajerowski DM,Hong T,Chi S,Ehlers G,Delaire O

    更新日期：2020-09-04 00:00:00

  • Metallization and molecular dissociation of dense fluid nitrogen.

    abstract：:Diatomic nitrogen is an archetypal molecular system known for its exceptional stability and complex behavior at high pressures and temperatures, including rich solid polymorphism, formation of energetic states, and an insulator-to-metal transformation coupled to a change in chemical bonding. However, the thermobaric c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05011-z

    authors： Jiang S,Holtgrewe N,Lobanov SS,Su F,Mahmood MF,McWilliams RS,Goncharov AF

    更新日期：2018-07-06 00:00:00

  • DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer.

    abstract：:Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8758

    authors： Stone A,Zotenko E,Locke WJ,Korbie D,Millar EK,Pidsley R,Stirzaker C,Graham P,Trau M,Musgrove EA,Nicholson RI,Gee JM,Clark SJ

    更新日期：2015-07-14 00:00:00

  • Cumulative learning enables convolutional neural network representations for small mass spectrometry data classification.

    abstract：:Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19354-z

    authors： Seddiki K,Saudemont P,Precioso F,Ogrinc N,Wisztorski M,Salzet M,Fournier I,Droit A

    更新日期：2020-11-05 00:00:00

  • Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome.

    abstract：:Removal of internal transcribed spacer 2 (ITS2) from pre-ribosomal RNA is essential to make functional ribosomes. This complicated processing reaction begins with a single endonucleolytic cleavage followed by exonucleolytic trimming at both new cleavage sites to generate mature 5.8S and 25S rRNA. We reconstituted the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01786-9

    authors： Fromm L,Falk S,Flemming D,Schuller JM,Thoms M,Conti E,Hurt E

    更新日期：2017-11-27 00:00:00

  • Macromolecular and electrical coupling between inner hair cells in the rodent cochlea.

    abstract：:Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 3...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17003-z

    authors： Jean P,Anttonen T,Michanski S,de Diego AMG,Steyer AM,Neef A,Oestreicher D,Kroll J,Nardis C,Pangršič T,Möbius W,Ashmore J,Wichmann C,Moser T

    更新日期：2020-06-25 00:00:00

  • Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal.

    abstract：:Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10062

    authors： Bui TP,Ritari J,Boeren S,de Waard P,Plugge CM,de Vos WM

    更新日期：2015-12-01 00:00:00

  • Frustrated supercritical collapse in tunable charge arrays on graphene.

    abstract：:The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08371-2

    authors： Lu J,Tsai HZ,Tatan AN,Wickenburg S,Omrani AA,Wong D,Riss A,Piatti E,Watanabe K,Taniguchi T,Zettl A,Pereira VM,Crommie MF

    更新日期：2019-01-29 00:00:00

  • The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans.

    abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3846

    authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

    更新日期：2013-01-01 00:00:00