解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Multifactorial etiology is involved in premature atherosclerosis related to diabetes. Most of the mechanisms that are responsible for the etiology in diabetes have remained unsolved so far. Type 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, whi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5001-1
更新日期:2006-06-01 00:00:00
abstract::The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols, modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a co...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5119-1
更新日期:2006-05-01 00:00:00
abstract::A group of Angus beef cattle was removed from temperate pastures and fed a very low beta-carotene cereal-based ration in a feedlot for over 300 d. Half the group was supplemented weekly with retinyl palmitate (at the rate of 60,000 IU vitamin A/100 live weight (LW)/day), sufficient to offset clinical vitamin A deficie...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5107-5
更新日期:2006-04-01 00:00:00
abstract::Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to determine if 39 g soy (85 mg aglycone isoflavones, treatment) compar...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-006-5095-5
更新日期:2006-03-01 00:00:00
abstract::Trans FA (TFA) have at least one trans double bond and comprise several isomers and types, including many of the CLA (e.g., c9,t11-18:2 CLA). Some TFA may have adverse effects (e.g., cardiovascular disease), whereas some are thought to have beneficial effects (e.g., anticarcinogenicity). The presence of TFA in human t...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-006-5082-x
更新日期:2006-02-01 00:00:00
abstract::The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9,trans-11 CLA (9c,11 tCLA); trans-10,cis-12 CLA (10t,12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic hamsters. One hundred ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5068-8
更新日期:2006-01-01 00:00:00
abstract::Recently, a number of inhibitors of the enzyme oxidosqualene cyclase (OSC; EC 5.4.99.7), a key enzyme in sterol biosynthesis, were shown to inhibit in mammalian cells the multiplication of Trypanosoma cruzi, the parasite agent of Chagas' disease. The gene coding for the OSC of T. cruzi has been cloned and expressed in...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1493-y
更新日期:2005-12-01 00:00:00
abstract::I-Tiao-Gung, Glycine tomentella, has been used extensively as a traditional herbal medicine to relieve physical pain, but its bioactivity has not been studied systematically. Ninety-five percent ethanol extracts of G. tomentella (GT-E) showed antioxidant activity in human plasma by prolonging the lag phase (+Tlag) of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1482-1
更新日期:2005-11-01 00:00:00
abstract::Lutein is an oxygenated carotenoid (xanthophyll) found in dark green leafy vegetables. High intakes of lutein may lower the risk of age-related macular degeneration. Current understanding of human lutein metabolism as it might occur in vivo is incomplete. Therefore, we conducted a feasibility study where we dosed a no...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1471-4
更新日期:2005-10-01 00:00:00
abstract::Flaxseed, echium, and canola oils contain alpha-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1461-6
更新日期:2005-10-01 00:00:00
abstract::The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1458-1
更新日期:2005-09-01 00:00:00
abstract::The beneficial roles of dietary fish oil in lowering serum TAG levels in animals and humans have been attributed in part to the high content of two n-3 polyunsaturated very long-chain FA, EPA, and DHA. Recent studies show that EPA induces mitochondrial beta-oxidation in hepatocytes, which might contribute to the syste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1443-8
更新日期:2005-08-01 00:00:00
abstract::In an attempt to combine the hypocholesterolemic properties of plant sterols with the hypotriglyceridemic action of fish oil FA, plant sterols have recently been esterified to fish oil n-3 PUFA. The objective of this study was to determine the effects of plant sterols esterified to n-3 PUFA on plasma lipid levels and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1432-y
更新日期:2005-07-01 00:00:00
abstract::We evaluated the effects of dietary lipid class (phospholipid vs. neutral lipid) and level of n-3 long-chain PUFA (LC-PUFA) on the growth, digestive enzymatic activity, and histological organization of the intestine and liver in European sea bass larvae. Fish were fed from the onset of exogenous feeding at 7 to 37 d p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1422-0
更新日期:2005-06-01 00:00:00
abstract::The effects of droplet size and emulsifiers on oxidative stability of polyunsaturated TAG in oil-in-water (o/w) emulsions with droplet sizes of 0.806 +/- 0.0690, 3.28 +/- 0.0660, or 10.7 +/- 0.106 microm (mean +/- SD) were investigated. Hydroperoxide contents in the emulsion with a mean droplet size of 0.831 microm we...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1410-4
更新日期:2005-05-01 00:00:00
abstract::This paper represents the first synthesis, spectroscopic characterization, and antitumor evaluation of F-, N-, and S-containing C4alpha-FA derivatives of podophyllotoxin. In a synthetic strategy, a FA unit of 4-O-podophyllotoxinyl 12-hydroxyoctadec-Z-9-enoate 2, a derivative of podophyllotoxin, was functionalized at t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-1397-x
更新日期:2005-04-01 00:00:00
abstract::Active lipases were isolated from the culture supernatant of the basidiomycetous fungus Pleurotus sapidus by foam fractionation. The pH value, the gas flow, and the foaming period were systematically varied to optimize the transport of the enzymes into the foam phase. On a 70-mL scale, a maximum recovery of hydrolytic...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1389-x
更新日期:2005-03-01 00:00:00
abstract::Potato tuber lipoxygenase (ptLOX) has been shown to catalyze the aerobic formation of at least four major oxygenated derivatives of DHA. Two of the products--7,17(S)- and 10,17(S)-dihydro(pero)xy-DHA [7,17- and 10,17-diH(P)DHA]--were formed from soybean 15-LOX-derived 17(S)-hydro(pero)xy-DHA [17(S)-H(P)DHA], whereas t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1379-z
更新日期:2005-03-01 00:00:00
abstract::The sn-position of FA in membrane lipids has an influence on the physiological function of cells, is predictive for diseases, and therefore is useful for diagnostics. The current study compares the compositions of acyl chain substituents in the sn-1 and sn-2 positions of the glycerol backbones of phospholipids derived...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1377-1
更新日期:2005-02-01 00:00:00
abstract::The effects of feeding CLA to hens on newly hatched chick hepatic and carcass lipid content, liver TAG accumulation, and FA incorporation in chick tissues such as liver, heart, brain, and adipose were studied. These tissues were selected owing to their respective roles in lipid assimilation (liver), as a major oxidati...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1367-3
更新日期:2005-02-01 00:00:00
abstract::FA with varying chain lengths and an alpha-methyl group and/or a sulfur in the beta-position were tested as peroxisome proliferator-activated receptor (PPAR)alpha, -delta(beta), and -gamma ligands by transient transfection in COS-1 cells using chimeric receptor expression plasmids, containing cDNAs encoding the ligand...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1359-3
更新日期:2005-01-01 00:00:00
abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-004-1352-x
更新日期:2004-12-01 00:00:00
abstract::Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury, and infection in some individuals and these can lead, progressively, to sepsis and septic shock. The hyperinflammation is characterized by the production of inflammatory cytokines, arachidonic acid-...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1342-z
更新日期:2004-12-01 00:00:00
abstract::One of the possibilities for distinct actions of c9,t11- and the t10,c12-conjugated linoleic acid (CLA) isomers may be at the level of metabolism since the conjugated diene structure gives to CLA isomers and their metabolites a distinct pattern of incorporation into the lipid fraction and metabolism. In fact, CLA appe...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1341-0
更新日期:2004-11-01 00:00:00
abstract::Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis, catalyzing the rate-limiting step in the overall de novo synthesis of monounsaturated FA, mainly oleate and palmitoleate from stearoyl- and palmitoyl-CoA, respectively. Oleate and palmitoleate are the major monounsaturated FA of membrane phospholipid...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1331-2
更新日期:2004-11-01 00:00:00
abstract::The objective of the present study was to investigate the effect of three modified milk fats with different melting profiles on fasting and postprandial lipid responses and on fecal fat content in guinea pigs. We hypothesized that the consumption of modified milk fat with a high m.p. results in reduced fasting and pos...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1320-5
更新日期:2004-10-01 00:00:00
abstract::Fish easily accumulate n-3 PUFA of exogenous origin, but the underlying mechanisms are not well established in the whole animal. This study was undertaken to investigate whether this feature was physiologically associated with mitochondrial and peroxisomal capacities that differentially affect FA oxidation. For this p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1306-3
更新日期:2004-09-01 00:00:00
abstract::Steroids bearing ketone functionality at carbon-7 are found commonly in nature, and the most prevalent of these are the 7-keto-delta5-sterols. These substances have diverse biological properties and are present in biological samples and food products. For the purpose of studying this class of oxysterols, many chemical...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1299-y
更新日期:2004-08-01 00:00:00
abstract::In plants, two pathways are utilized for the synthesis of isopentenyl diphosphate (IPP), the universal precursor for isoprenoid biosynthesis. In this paper we review findings and observations made primarily with tobacco BY-2 cells (TBY-2), which have proven to be an excellent system in which to study the two biosynthe...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1289-0
更新日期:2004-08-01 00:00:00
abstract::Maternal smoking during pregnancy has been associated with a reduced content of n-3 long-chain PUFA (LC-PUFA) in breast milk, thereby reducing the intake of key nutrients by the infants. We postulated that the mammary gland is affected by maternal smoking in the process of n-3 LC-PUFA secretion into milk. This prompte...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1276-5
更新日期:2004-07-01 00:00:00
abstract::Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recognized feature of Lp(a) is its instability on storage caused by attenda...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1268-5
更新日期:2004-06-01 00:00:00
abstract::Commercial preparations of Candida rugosa lipase (CRL) are mixtures of lipase isoforms used for the hydrolysis and synthesis of various esters. The presence of variable isoforms and the amount of lipolytic protein in the crude lipase preparations lead to a lack of reproducibility of biocatalytic reactions. Purificatio...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1258-7
更新日期:2004-06-01 00:00:00
abstract::The influence of dietary TAG source (fish oil, triolein, and coconut oil) and level (7.5 and 15% of the diet) on growth, lipase activity, and mRNA level was studied in sea bass larvae, from mouth opening until day 24 and from day 37 to 52. Fish oil and triolein induced better growth in both experiments, this being sig...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1250-2
更新日期:2004-05-01 00:00:00
abstract::If an increased consumption of alpha-linolenic acid (ALA) is to be promoted in parallel with that of n-3 long-chain-rich food, it is necessary to consider to what extent dietary ALA can be absorbed, transported, stored, and converted into long-chain derivatives. We investigated these processes in male hamsters, over a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1236-0
更新日期:2004-04-01 00:00:00
abstract::Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1223-5
更新日期:2004-03-01 00:00:00
abstract::The purpose of this study was to examine the effects of two purified isomers of CLA (c9,t11-CLA and t10,c12-CLA) on the weights and FA compositions of hepatic TG, phospholipids, cholesterol esters, and FFA. Eight-week-old female mice (n = 6/group) were fed either a control diet or diets supplemented with 0.5% c9,t11-C...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1211-9
更新日期:2004-02-01 00:00:00
abstract::Cholesterol absorption is frequently determined using the plasma dual stable-isotope ratio method (PDSIRM). However, this method involves intravenous injection of stable-isotope-labeled cholesterol with simultaneous oral administration of differently labeled cholesterol, which results in high study costs and involves ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1206-6
更新日期:2004-01-01 00:00:00
abstract::The impact of starch sources differing in their velocities of ruminal degradation on the milk fat of dairy cows was studied. The animals received diets containing a slowly degradable (potatoes) or rapidly degradable (wheat) starch concentrate (40% of the dry matter) in a total mixed diet. Milk fat was the only animal ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1196-4
更新日期:2004-01-01 00:00:00
abstract::Twenty-three of 86 strains of lactic acid bacteria transformed linoleic acid into hydroxy FA. Two distinct conversion pathways were in operation. Two strains of Lactobacillus acidophilus and a strain of Pediococcus pentosaceus produced 13(S)-hydroxy-9-octadecenoic acid 113(S)-OH 18:11 and 10,13dihydroxyoctadecanoic ac...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1188-4
更新日期:2003-12-01 00:00:00
abstract::The farnesoid X receptor (FXR, NR1H4) has been recognized as an attractive therapeutic target because it is a nuclear hormone receptor that controls the expression level of cholesterol-7alpha-hydroxylase, which in turn regulates bile acid production and cholesterol excretion. To compare receptor activity between each ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1173-y
更新日期:2003-11-01 00:00:00