Monitoring the oxidation of docosahexaenoic acid in lipids.

Abstract:

:The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all positions. All lipids were incubated as bulk lipids, in chloroform, or as an emulsion in contact with air at 25-30 degrees C for 28 d. Since DHA, which is highly sensitive to oxidation, has a great impact on our health and is desired as a food additive, the stability of this FA is of great importance. This study was mainly focused on the primary oxidation products, which were monitored as eight monohydroperoxy-DHA isomer groups, the total amount of polyhydroperoxides, and the PV. However, a measure of secondary oxidation products, the carbonyl value, was also monitored. We found that DHA was most protected against hydroperoxide formation when it was incorporated at one position of either PC or PE. In these lipids, hydroperoxide formation at carbon atoms 4, 7, 8, and 11 was completely prevented. DHA mixed with PC was also protected, although to a lesser extent, and all hydroperoxide isomers were detected. In contrast, PC and TG containing DHA at all positions should be avoided, since they were highly oxidized.

journal_name

Lipids

journal_title

Lipids

authors

Lyberg AM,Fasoli E,Adlercreutz P

doi

10.1007/s11745-005-1458-1

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

969-79

issue

9

eissn

0024-4201

issn

1558-9307

journal_volume

40

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Apolipoprotein E polymorphism: automated determination of apolipoprotein E2, E3, and E4 isoforms.

    abstract::Apolipoprotein E (apo E) plays an essential role in lipoprotein metabolism, where it is involved in the clearance of chylomicrons and very low density lipoproteins. Apart from some rare variants, apo E exists in three common isoforms (E2, E3, and E4). The different isoforms have not only been associated with different...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0500-7

    authors: Wiebe C,Holzem G,Wielckens K,Klingler KR

    更新日期:2000-01-01 00:00:00

  • Seasonal variations of lipid content and composition in Perna viridis.

    abstract::The total lipid content, composition of main lipid classes, composition of sterols and composition of fatty acids in the main glycerolipids of Perna viridis were analyzed through four seasons using TLC-FID and GLC. Mussel samples were collected during different seasons between 2003 and 2004 from Shengsi Island, Zhejia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3078-9

    authors: Li D,Zhang Y,Sinclair AJ

    更新日期:2007-08-01 00:00:00

  • Serum phospholipid transfer protein activity after a high fat meal in patients with insulin-treated type 2 diabetes.

    abstract::Plasma phospholipid transfer protein (PLTP) mediates both net transfer and exchange of phospholipids between different lipoproteins. Animal studies have shown that it is closely related to the development of atherosclerosis. Although many studies have indicated that PLTP activity is increased in diabetes mellitus, the...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3384-5

    authors: Schlitt A,Schwaab B,Fingscheidt K,Lackner KJ,Heine GH,Vogt A,Buerke M,Maegdefessel L,Raaz U,Werdan K,Jiang XC

    更新日期:2010-02-01 00:00:00

  • Review of chemical syntheses of 7-keto-delta5-sterols.

    abstract::Steroids bearing ketone functionality at carbon-7 are found commonly in nature, and the most prevalent of these are the 7-keto-delta5-sterols. These substances have diverse biological properties and are present in biological samples and food products. For the purpose of studying this class of oxysterols, many chemical...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1299-y

    authors: Parish EJ,Kizito SA,Qiu Z

    更新日期:2004-08-01 00:00:00

  • Comparative study of lipogenic enzymes in several vertebrates.

    abstract::The liver lipogenic enzymes are compared among rats, chickens, frogs and fish. Although the apparent Km values of glucose-6-phosphate dehydrogenase for glucose-6-phosphate are not much different among all the species, those of malic enzyme for malate are much higher in chickens and fish than in rats and frogs. Glucose...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534511

    authors: Iritani N,Ikeda Y,Fukuda H,Katsurada A

    更新日期:1984-11-01 00:00:00

  • Replacement of dietary fish oil with increasing levels of linseed oil: modification of flesh fatty acid compositions in Atlantic salmon (Salmo salar) using a fish oil finishing diet.

    abstract::Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1223-5

    authors: Bell JG,Henderson RJ,Tocher DR,Sargent JR

    更新日期:2004-03-01 00:00:00

  • Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors.

    abstract::Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-010-3524-y

    authors: Gillingham LG,Harris-Janz S,Jones PJ

    更新日期:2011-03-01 00:00:00

  • Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids.

    abstract::The purpose of this study was to examine the effects of two purified isomers of CLA (c9,t11-CLA and t10,c12-CLA) on the weights and FA compositions of hepatic TG, phospholipids, cholesterol esters, and FFA. Eight-week-old female mice (n = 6/group) were fed either a control diet or diets supplemented with 0.5% c9,t11-C...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1211-9

    authors: Kelley DS,Bartolini GL,Warren JM,Simon VA,Mackey BE,Erickson KL

    更新日期:2004-02-01 00:00:00

  • Effect of low methionine, choline deficient diets upon major unsaturated phosphatidyl choline fractions of rat liver and plasma.

    abstract::To see how the metabolism of specific phosphatidyl choline fractions might be affected when only a limited source of methyl groups was available, rats were fed for 7 days a low methionine, choline-deficient diet or one supplemented with either choline or methionine. Prior to killing, they were injected with -14C-methy...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534154

    authors: Lyman RL,Giotas C,Medwadowski B,Miljanich P

    更新日期:1975-03-01 00:00:00

  • Increased diaphragm expression of GLUT4 in control and streptozotocin-diabetic rats by fish oil-supplemented diets.

    abstract::Dietary fat intake influences plasma glucose concentration through modifying glucose uptake and utilization by adipose and skeletal muscle tissues. In this paper, we studied the effects of a low-fat diet on diaphragm GLUT4 expression and fatty acid composition in control and streptozotocin-induced diabetic rats. Contr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0426-0

    authors: Girón MD,Salto R,Hortelano P,Periago JL,Vargas AM,Suárez MD

    更新日期:1999-08-01 00:00:00

  • Inevitable generation of primary alcohols during reduction of oxidized lipids with sodium borohydride.

    abstract::This report deals with the fluorometric determination of fatty alcohols generated by the reduction of the ester linkage of lipids with NaBH4, and with the limitations of the reduction method for assaying oxidized lipids. Optimum conditions for the fluorometric analysis of primary and secondary alcohols using 1-anthroy...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537169

    authors: Nakamura T,Maeda H,Takahashi Y,Hama Y

    更新日期:1990-09-01 00:00:00

  • Mechanism of linoleic acid hydroperoxide reaction with alkali.

    abstract::Treatment of (13S,9Z,11E)-13-hydroperoxy-9,11-octadecadienoic acid (13S-HPODE) with strong alkali resulted in the formation of about 75% of the corresponding hydroxy acid, (13S,9Z,11E)-13-hydroxy-9,11-octadecadienoic acid (13S-HODE), and the remaining 25% of products was a mixture of several oxidized fatty acids, the ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522458

    authors: Gardner HW,Simpson TD,Hamberg M

    更新日期:1996-10-01 00:00:00

  • An ethanolamine plasmalogen artifact formed by acetone extraction of freeze-dried tissue.

    abstract::Extraction of freeze-dried tissues by acetone results in the in vitro production of an acetone derivative (imine) of the ethanolamine phosphatides. Some of the properties of the acetone imine of ethanolamine plasmalogen are discussed. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02531616

    authors: Helmy FM,Hack MH

    更新日期:1966-07-01 00:00:00

  • Sex- and age-related differences in ceramide dihexosides of primary human brain tumors.

    abstract::Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 hu...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-330-7

    authors: Yates AJ,Franklin TK,Scheithauer BW,Burger PC,Pearl DK

    更新日期:1999-01-01 00:00:00

  • Curcumin Attenuates Lipopolysaccharide-Induced Hepatic Lipid Metabolism Disorder by Modification of m6 A RNA Methylation in Piglets.

    abstract::N6 -methyladenosine (m6 A) regulates gene expression and affects cellular metabolism. In this study, we checked whether the regulation of lipid metabolism by curcumin is associated with m6 A RNA methylation. We investigated the effects of dietary curcumin supplementation on lipopolysaccharide (LPS)-induced liver injur...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12023

    authors: Lu N,Li X,Yu J,Li Y,Wang C,Zhang L,Wang T,Zhong X

    更新日期:2018-01-01 00:00:00

  • Changes in liver fatty acid unsaturation after partial hepatectomy in the rat.

    abstract::The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsatura...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-543-9

    authors: Kishino T,Tanno M,Yamada H,Saito S,Matsumoto S

    更新日期:2000-04-01 00:00:00

  • Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane.

    abstract::The evaluation of antioxidant activity in vivo is difficult. In this study, the effects of dietary natural and synthetic antioxidants on the lipid peroxidation in mice were assessed using a biomarker, total hydroxyoctadecadienoic acid (tHODE). Biological samples such as plasma, erythrocytes, and tissues were first red...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3043-7

    authors: Yoshida Y,Hayakawa M,Habuchi Y,Itoh N,Niki E

    更新日期:2007-05-01 00:00:00

  • Acyl-Trafficking During Plant Oil Accumulation.

    abstract::Vegetable oils are an extremely important agricultural commodity. Their use has risen inexorably for the last 50 years and will undoubtedly be even more prevalent in the future. They have a role not only in foodstuffs but also as renewable chemicals. However, our understanding of their metabolism, and particularly its...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4069-x

    authors: Chen G,Woodfield HK,Pan X,Harwood JL,Weselake RJ

    更新日期:2015-11-01 00:00:00

  • Hepatic bile acid elution by albumin and bile acid content in isolated rat hepatocytes.

    abstract::Bile acid contents were determined for isolated rat hepatocytes. During the course of isolating the hepatocytes, perfusion of rat liver with buffer containing 2% albumin eluted a significant amount of bile acids. The elution was proportional to the volume of the buffer and attributable to albumin in the buffer. The is...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535094

    authors: Hashimoto S,Uchida K,Hirata M

    更新日期:1982-03-01 00:00:00

  • Essentiality of fatty acids.

    abstract::All fatty acids have important functions, but the term "essential" is applied only to those polyunsaturated fatty acids (PUFA) that are necessary for good health and cannot be completely synthesized in the body. The need for arachidonic acid, which is utilized for eicosanoid synthesis and is a constituent of membrane ...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/BF02562220

    authors: Spector AA

    更新日期:1999-01-01 00:00:00

  • Determination of individual long-chain fatty acyl-CoA esters in heart and skeletal muscle.

    abstract::A method has been developed for determination of individual long-chain fatty acyl-CoA esters from heart and skeletal muscle using high performance liquid chromatography (HPLC). The esters were extracted from freeze-clamped tissue of pig and rat hearts and rat skeletal muscle for analysis on a radially compressed C18 5...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535525

    authors: Molaparast-Saless F,Shrago E,Spennetta TL,Donatello S,Kneeland LM,Nellis SH,Liedtke AJ

    更新日期:1988-05-01 00:00:00

  • Concentration-dependent effects of eicosapentaenoic acid on very low density lipoprotein secretion by the isolated perfused rat liver.

    abstract::The effects of increasing concentrations of eicosapentaenoic acid (20:5n-3; EPA) and oleic acid (18:1n-9; OA) on esterification to triacylglycerols (TG) and phospholipids (PL), and the relationship to formation and secretion of the very low density lipoproteins (VLDL) were compared in the isolated perfused rat liver. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535940

    authors: Zhang ZJ,Wilcox HG,Castellani L,Fungwe TV,Elam MB,Heimberg M

    更新日期:1993-05-01 00:00:00

  • Difficulties in the assay of phosphatidate phosphohydrolase activity. Influence of ionic strength, detergent, and selection of substrate.

    abstract::In the present paper, problems in connection with assay of the activity of magnesium-dependent rat liver phosphatidate phosphohydrolase (PAP) are discussed. PAP activity is usually measured by following the production of diacylglycerol or inorganic phosphate from the substrate phosphatidate. These two methods may give...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522468

    authors: Stark M,Humble E

    更新日期:1996-10-01 00:00:00

  • Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis.

    abstract::The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533962

    authors: Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

    更新日期:1995-09-01 00:00:00

  • Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population.

    abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3027-7

    authors: Pérez-Martínez P,Pérez-Jiménez F,Ordovás JM,Moreno JA,Marín C,Moreno R,Jiménez-Gómez Y,Paniagua JA,López-Miranda J

    更新日期:2007-03-01 00:00:00

  • Evaluation of chromic oxide, glycerol triether, and beta-sitosterol as fecal flow markers in two species of nonhuman primates.

    abstract::Recovery of beta-sitosterol, glycerol triether (1-hexadecyl-2,3-didodecyl glycerol triether), and chromic oxide was studied in African green monkeys and stumptail macaques consuming diets containing 0.75 mg/Cal cholesterol and 38% of calories as safflower oil or butter. Following oral administration of these compounds...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532190

    authors: St Clair RW,Lehner ND,Hamm TE

    更新日期:1975-01-01 00:00:00

  • Protein engineering and applications of Candida rugosa lipase isoforms.

    abstract::Commercial preparations of Candida rugosa lipase (CRL) are mixtures of lipase isoforms used for the hydrolysis and synthesis of various esters. The presence of variable isoforms and the amount of lipolytic protein in the crude lipase preparations lead to a lack of reproducibility of biocatalytic reactions. Purificatio...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1258-7

    authors: Akoh CC,Lee GC,Shaw JF

    更新日期:2004-06-01 00:00:00

  • Lipid composition and peroxide levels of mucosal cells in the rat large intestine in relation to dietary fat.

    abstract::To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in "non-proliferative" and "proliferative" cells in the large intestine, Sprague-Dawley rats were fed diets providing a polyunsaturated-to-saturated fatty acid ratio of 1.2 or 0.3 at a high or low level of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536069

    authors: Turini ME,Thomson AB,Clandinin MT

    更新日期:1991-06-01 00:00:00

  • Flaxseed treatments to reduce biohydrogenation of alpha-linolenic acid by rumen microbes in cattle.

    abstract::Enrichment of beef muscle with n-3 fatty acids (FA) is one means to introduce these FA into the diet, but ruminal biohydrogenation limits their bioavailability. To address this problem, we evaluated the ability of condensed tannin (quebracho), in the presence or absence of casein, to protect 18:3n-3 in flaxseed from h...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3126-5

    authors: Kronberg SL,Scholljegerdes EJ,Barceló-Coblijn G,Murphy EJ

    更新日期:2007-12-01 00:00:00

  • Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats.

    abstract::The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CL...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0236-4

    authors: Sugano M,Tsujita A,Yamasaki M,Noguchi M,Yamada K

    更新日期:1998-05-01 00:00:00