Abstract:
:If an increased consumption of alpha-linolenic acid (ALA) is to be promoted in parallel with that of n-3 long-chain-rich food, it is necessary to consider to what extent dietary ALA can be absorbed, transported, stored, and converted into long-chain derivatives. We investigated these processes in male hamsters, over a broad range of supply as linseed oil (0.37, 3.5, 6.9, and 14.6% energy). Linoleic acid (LA) was kept constant (8.5% energy), and the LA/ALA ratio was varied from 22.5 to 0.6. The apparent absorption of individual FA was very high (>96%), and that of ALA remained almost maximum even at the largest supply (99.5%). The capacity for ALA transport and storage had no limitation over the chosen range of dietary intake. Indeed, ALA intake was significantly correlated with ALA level not only in cholesteryl esters (from 0.3 to 9.7% of total FA) but also in plasma phospholipids and red blood cells (RBC), which makes blood components extremely reliable as biomarkers of ALA consumption. Similarly, ALA storage in adipose tissue increased from 0.85 to 14% of total FA and was highly correlated with ALA intake. As for bioconversion, dietary ALA failed to increase 22:6n-3, decreased 20:4n-6, and efficiently increased 20:5n-3 (EPA) in RBC and cardiomyocytes. EPA accumulation did not tend to plateau, in accordance with identical activities of delta5- and delta6-desaturases in all groups. Dietary supply of ALA was therefore a very efficient means of improving the 20:4n-6 to 20:5n-3 balance.
journal_name
Lipidsjournal_title
Lipidsauthors
Morise A,Combe N,Boué C,Legrand P,Catheline D,Delplanque B,Fénart E,Weill P,Hermier Ddoi
10.1007/s11745-004-1236-0subject
Has Abstractpub_date
2004-04-01 00:00:00pages
325-34issue
4eissn
0024-4201issn
1558-9307journal_volume
39pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Two groups of volunteers had blood drawn for serum analysis of fatty acids. The first group was comprised of patients admitted to the hospital with possible myocardial infarction (MI). Blood was drawn at admission and at 12, 24 and 48 hr. These patients were subsequently divided into three groups, those with MI, those...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535594
更新日期:1988-06-01 00:00:00
abstract::The effects of droplet size and emulsifiers on oxidative stability of polyunsaturated TAG in oil-in-water (o/w) emulsions with droplet sizes of 0.806 +/- 0.0690, 3.28 +/- 0.0660, or 10.7 +/- 0.106 microm (mean +/- SD) were investigated. Hydroperoxide contents in the emulsion with a mean droplet size of 0.831 microm we...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1410-4
更新日期:2005-05-01 00:00:00
abstract::We studied the actions of oxysterols on fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells. Cultures were labeled with [1-14C]arachidonate or [1-14C]oleate. During a 24-hr incubation, 25- or 22R-hydroxycholesterol enhanced the incorporation of label into triglycerides, concomitan...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544334
更新日期:1990-03-01 00:00:00
abstract::Schizochytrium sp. is an algae-like microorganism utilized for commercial production of docosahexaenoic acid (DHA)-rich oil and dried microalgae for use as a source of DHA in foods, feeds, and nutritional supplements. Electron microscopic analysis of whole cells of Schizochytrium sp. employing sample preparation by hi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0655-2
更新日期:2000-12-01 00:00:00
abstract::In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propos...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534407
更新日期:1985-11-01 00:00:00
abstract::In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-delta-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, omega-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535024
更新日期:1981-04-01 00:00:00
abstract::Milk fatty acids consist of about 20-25% palmitic acid (16:0), with about 70% of 16:0 esterified to the sn-2 position of the milk triacylglycerols. Hydrolysis of dietary triacylglycerols by endogeneous lipases produces sn-2 monoacylglycerols and free fatty acids, which are absorbed, reesterified, and then secreted int...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/BF02536625
更新日期:1994-08-01 00:00:00
abstract::The Ca and Mg content of flax and corn phosphatidyl inositol fractions has been determined. Procedures were devised to prepare various salt forms of phosphatidyl inositol. The divalent cations were exchanged for monovalent ions (Na or K) on chelating resin columns. With the Folch wash procedure the Na or K forms of ph...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02668119
更新日期:1966-01-01 00:00:00
abstract::Administration of 2,2'''-([1-methyl-4, 4-diphenylbutylidene] bis(p-phenyl-eneoxy]) bistriethylamine oxalate (SQ 10,591) at 20 mg/Kg daily for 5 days to cholesterol-fed rabbits resulted in no change in aortic microsomal cholesterol esterification with a palmitoyl coenzyme A substrate or of aortic mitochondrial choleste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532164
更新日期:1975-02-01 00:00:00
abstract::The phospholipid composition of gill tissue from thermally acclimated rainbow trout, Salmo gairdneri, was determined by Iatroscan analysis following an initial development of the chromarods in a non-polar solvent to remove neutral lipids. Standard curves for all phospholipids, although linear through most of the conce...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534892
更新日期:1985-08-01 00:00:00
abstract::Using the spectrofluorimetric method described by Wittenauer et al. [Wittenauer, L.A., Shirai, K., Jackson, R.L., and Johnson, J.D. (1984) Biochem. Biophys. Res. Commun. 118, 894-901] for phospholipase A2 (PLA2) measurement, we have detected a phospholipase activity in Ailsa Craig and in mutant rin tomatoes at their n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537801
更新日期:1995-08-01 00:00:00
abstract::In humans and animals, intestinal flora is indispensable for bile acid transformation. The goal of our study was to establish gnotobiotic mice with intestinal bacteria of human origin in order to examine the role of intestinal bacteria in the transformation of bile acids in vivo using the technique of gnotobiology. Ei...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5038-1
更新日期:2006-09-01 00:00:00
abstract::Lipophilic toxins have been introduced into the environment both as functional compounds, such as pesticides, and as industrial waste from incineration or the manufacture of electrical transformer components. Among these substances are compounds that are carcinogenic and that affect the endocrine system. Accidental hi...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-001-0844-z
更新日期:2001-12-01 00:00:00
abstract::An unidentified bacterial strain, SCRC-21406, isolated from the intestine of a marine fish, Glossanodon semifasciatus, produced docosahexaenoic acid at 23% (mol/mol) [= 28% (w/w)] of total fatty acids in a medium containing 0.5% (wt/vol) peptone and 0.1% (wt/vol) yeast extract at 12 degrees C under atmospheric pressur...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0127-8
更新日期:1997-09-01 00:00:00
abstract::During ruminal biohydrogenation of α-linolenic acid, a non-conjugated non-methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15-18:2. The present study was designed to examine whether t10,c15-18:2 would exert similar anti-adipogenic effects compared to t10,c12-18:2 in 3T3-L1 adipocy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4192-3
更新日期:2016-11-01 00:00:00
abstract::A detailed structural diversity of dienoic fatty acids (FA), including non-methylene-interrupted dienoic FA, of triacylglycerols and polar lipids in ovaries of Cellana toreuma was clarified for the first time by using capillary gas chromatography-mass spectrometry of their 3-pyridylcarbinol esters and argentation thin...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4107-8
更新日期:2016-02-01 00:00:00
abstract::The monoazaaromatics, pyridine (1), hexyl nicotinate (2), and quinoline (3) and diazaaromatics, pyrimidine (4) and purine (5), readily act as photo-initiators for the peroxidation of methyl linoleate in 0.50 M SDS at 37 degrees C giving free radical chain oxidations of linoleate. Quantitative kinetic runs on the order...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0030-3
更新日期:1997-03-01 00:00:00
abstract::In guinea pigs, total plasma cholesterol concentrations increased above the control values after single intravenous injections and after 3 days of continuous subcutaneous administration of neurotensin (NT). A high dose of NT (125 pmol/100 g body weight) induced tachycardia and severe respiratory distress; the lowest d...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534468
更新日期:1984-10-01 00:00:00
abstract::The incorporation of arachidonic acid (AA) as compared to eicosapentaenoic acid (EPA) into human platelet phospholipids was tested by incubating washed platelets with a known mixture of [3H]AA and [14C]EPA. Following incubation, the platelet lipids were extracted, the individual phospholipids--phosphatidylcholine (PC)...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534401
更新日期:1985-11-01 00:00:00
abstract::The effects of dietary stearidonic acid (18:4n-3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of two other n-3 PUFA: alpha-linolenic acid (18:3n-3) and EPA (20:5n-3). TAG mixtures containing 10% of 18:4n-3, 18:3n-3, or 20:5n-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-0921-3
更新日期:2002-05-01 00:00:00
abstract::One of the possibilities for distinct actions of c9,t11- and the t10,c12-conjugated linoleic acid (CLA) isomers may be at the level of metabolism since the conjugated diene structure gives to CLA isomers and their metabolites a distinct pattern of incorporation into the lipid fraction and metabolism. In fact, CLA appe...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1341-0
更新日期:2004-11-01 00:00:00
abstract::Using an experimental model that enables the effects of alcohol to be distinguished from the effects of the nonalcoholic components present in wine, we determined whether wine has effects other than those of alcohol on the metabolism of cholesterol. Male rats were fed a standard diet and had free access to water and e...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0732-6
更新日期:2001-04-01 00:00:00
abstract::This study investigated a possible role for the epidermal growth factor (EGF) receptor protein tyrosine kinase in phosphoinositide metabolism with plasma membrane vesicles from human epidermoid carcinoma (A431) cells. We found a novel chloroform-soluble product radiolabeled with [gamma-32P]ATP that did not migrate fro...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534242
更新日期:1985-07-01 00:00:00
abstract::Conjugated linoleic acid (CLA) has been demonstrated to reduce body fat in animals. However, the mechanism by which this reduction occurs is unknown. Leptin may mediate the effect of CLA to decrease body fat. We assessed the effects of 64 d of CLA supplementation (3 g/d) on circulating leptin, insulin, glucose, and la...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0586-y
更新日期:2000-07-01 00:00:00
abstract::Rats were fed diets with three different ratios of alpha-linolenate (18:3 n-3) and linoleate (18:2 n-6), and then crescentic-type anti-glomerular basement membrane (GBM) nephritis was induced. The urinary protein levels and the plasma urea nitrogen levels were significantly higher, and histological abnormalities of gl...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544386
更新日期:1990-05-01 00:00:00
abstract::Unsaturated free fatty acids (FFA) are able to prevent deleterious effects of saturated FFA in skeletal muscle cells although the mechanisms involved are still not completely understood. FFA act as endogenous ligands of peroxisome proliferator-activated receptors (PPAR), transcription factors regulating the expression...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4058-0
更新日期:2015-10-01 00:00:00
abstract::Choline is an essential nutrient required for the biosynthesis of membrane lipid phosphatidylcholine (PtdCho). Here we elucidate the mechanism of how palmitic acid (PAM) and oleic acid (OLA) regulate choline transporter-like protein 1 (CTL1/SLC44A1) function. We evaluated the mechanism of extracellular and intracellul...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3925-4
更新日期:2014-08-01 00:00:00
abstract::Several water soluble and organic solvent soluble fluorescent peaks were observed in extracts of uteri from vitamin E deficient or supplemented rats following Sephadex column chromatography and spectrophotofluorometric analysis. Levels of one of the organic and two of the water soluble fluorescent peaks were found to ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534725
更新日期:1984-12-01 00:00:00
abstract::The cytotoxicity of fatty acids from seed oils containing conjugated linolenic acids (CLN) was studied. Fatty acids from pomegranate, tung, and catalpa were cytotoxic to human monocytic leukemia cells at concentrations exceeding 5 microM for pomegranate and tung and 10 microM for catalpa, but fatty acids from pot mari...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0746-0
更新日期:2001-05-01 00:00:00
abstract::Acyl-CoA cholesterol acyltransferase (ACAT) (EC 2.3.1.26) in the yolk sac membrane of chicken eggs plays an important role in the transport of lipids, which serve as both structural components and as an energy source during embryogenesis. ACAT from the yolk sac membrane of chicken eggs 16 d after fertilization has hig...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0362-z
更新日期:1999-03-01 00:00:00