Lactoperoxidase-catalyzed iodination of arachidonic acid: formation of macrolides.

Abstract:

:In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-delta-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, omega-lactone and 14-iodo-15-hydroxyeicosatrienoic acid, omega-lactone, on the basis of 125I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.

journal_name

Lipids

journal_title

Lipids

authors

Boeynaems JM,Reagan D,Hubbard WC

doi

10.1007/BF02535024

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

246-9

issue

4

eissn

0024-4201

issn

1558-9307

journal_volume

16

pub_type

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