Factors affecting the storage and excretion of toxic lipophilic xenobiotics.

abstract：:The current study evaluated the composition and relationships of polyunsaturated fatty acid biohydrogenation products (PUFA-BHP) from the perirenal (PRF) and subcutaneous fat (SCF) of yearling steers fed a 70 % grass hay diet with concentrates containing either sunflower-seed (SS) or flaxseed (FS). Analysis of varianc...

journal_title：Lipids

authors： Mapiye C,Aalhus JL,Turner TD,Rolland DC,Basarab JA,Baron VS,McAllister TA,Block HC,Proctor SD,Dugan ME

更新日期：2014-03-01 00:00:00

abstract：:We have previously shown that adipose cells from young genetically obese Zucker rats are characterized by very high metabolic activity together with an increase in a wide range of membrane-mediated functions. The aim of the present study was to examine whether the physical properties of the membranes and the compositi...

journal_title：Lipids

authors： Guerre-Millo M,Guesnet P,Guichard C,Durand G,Lavau M

更新日期：1994-03-01 00:00:00

abstract：:The de novo synthesis of choline and ethanolamine phosphoglycerides in brain microsomes from 18 month-old male rats was investigated in vitro by using labeled cytidine-5'-diphosphate choline and cytidine-5'-diphosphate ethanolamine as lipid precursors. The rate of synthesis of the two phospholipid classes was found to...

journal_title：Lipids

authors： Brunetti M,Gaiti A,Porcellati G

更新日期：1979-11-01 00:00:00

abstract：:In order to further characterize low density lipoprotein (LDL)-platelet interaction, we investigated the effect of protease pretreatment of human platelets on the subsequent binding of iodinated LDL (125I-LDL). Our results showed that the platelet LDL receptor had a proteolytic susceptibility different from that of bo...

journal_title：Lipids

authors： Pedreño J,Fernández R

更新日期：1995-10-01 00:00:00

abstract：:Lipids were extracted from four dog adipose tissue sites, perirenal, pericardial, inguinal subcutaneous, and mesenteric. The triglycerides were purified by thin-layer chromatography and the sub-classes separated by silver nitrate-silica gel plates. Gas chromatography was used to delineate the fatty acid composition of...

journal_title：Lipids

authors： Gold M

更新日期：1968-11-01 00:00:00

abstract：:The physiological role of long-chain fatty acyl-CoA is thought to be primarily in intermediary metabolism of fatty acids. However, recent data show that nM to microM levels of these lipophilic molecules are potent regulators of cell functions in vitro. Although long-chain fatty acyl-CoA are present at several hundred ...

journal_title：Lipids

authors： Gossett RE,Frolov AA,Roths JB,Behnke WD,Kier AB,Schroeder F

更新日期：1996-09-01 00:00:00

abstract：:To see how the metabolism of specific phosphatidyl choline fractions might be affected when only a limited source of methyl groups was available, rats were fed for 7 days a low methionine, choline-deficient diet or one supplemented with either choline or methionine. Prior to killing, they were injected with -14C-methy...

journal_title：Lipids

authors： Lyman RL,Giotas C,Medwadowski B,Miljanich P

更新日期：1975-03-01 00:00:00

abstract：:The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsatura...

journal_title：Lipids

authors： Kishino T,Tanno M,Yamada H,Saito S,Matsumoto S

更新日期：2000-04-01 00:00:00

abstract：:Diacylglycerol acyltransferase (DGAT) catalyzes the final step of triacylglycerol (TAG) synthesis, and is considered as a potential target to control hypertriglyceridemia or other metabolic disorders. In this study, we found that the extract of rose petals suppressed TAG synthesis in cultured cells, and that the extra...

journal_title：Lipids

authors： Kondo H,Hashizume K,Shibuya Y,Hase T,Murase T

更新日期：2011-08-01 00:00:00

abstract：:Recently, significant differences between rats fed a casein diet and rats fed a soybean protein diet have been observed in hepatic phospholipid fatty acid patterns (Sjöblom, L., and Eklund, A., Biochim. Biophys. Acta 1004, 187-192, 1990). The influence of these two diets on the delta 6 desaturase activity was investig...

journal_title：Lipids

authors： Lindholm M,Eklund A

更新日期：1991-02-01 00:00:00

abstract：:Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) are essential components of the diet of all vertebrates. The major dietary source of n-3 LC-PUFA for humans has been fish and seafood but, paradoxically, farmed fish are also reliant on marine fisheries for fish meal and fish oil (FO), traditionally major ...

journal_title：Lipids

authors： Betancor MB,Sprague M,Montero D,Usher S,Sayanova O,Campbell PJ,Napier JA,Caballero MJ,Izquierdo M,Tocher DR

更新日期：2016-10-01 00:00:00

abstract：:The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-alpha-tocopheryl acetate for 6 wk. Tocopherol levels in the diets, plasma, liver, kidn...

journal_title：Lipids

authors： Meydani SN,Shapiro AC,Meydani M,Macauley JB,Blumberg JB

更新日期：1987-05-01 00:00:00

abstract：:I-Tiao-Gung, Glycine tomentella, has been used extensively as a traditional herbal medicine to relieve physical pain, but its bioactivity has not been studied systematically. Ninety-five percent ethanol extracts of G. tomentella (GT-E) showed antioxidant activity in human plasma by prolonging the lag phase (+Tlag) of ...

journal_title：Lipids

authors： Chen TY,Shiao MS,Pan BS

更新日期：2005-11-01 00:00:00

abstract：:The objective of the present studies was to examine the effect of dietary fat on the lipid composition of rat colonocytes and their utilization of short-chain fatty acids (SCFA). Rats were fed 14% beef fat, fish oil or safflower oil plus 2% corn oil in a semi-synthetic base diet for 4 wk. Colonocytes were isolated and...

journal_title：Lipids

authors： Awad AB,Ferger SL,Fink CS

更新日期：1990-06-01 00:00:00

abstract：:The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

journal_title：Lipids

authors： Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

更新日期：1995-09-01 00:00:00

abstract：:The amount and composition of lysophosphatidate present in different rat tissues have been estimated by an internal standard method in which a synthetic unnatural isomer (1-heptadecanoyl-rac-glycerol-3-phosphate) was added to the total lipid extracts, and the fatty acid composition of purified lysophosphatidate was de...

journal_title：Lipids

authors： Das AK,Hajra AK

更新日期：1989-04-01 00:00:00

abstract：:Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half-maximal inhibition of cholesterogenesis occurs at ca. 10 micro M chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. This suggests that chloroquine acts on the cholesterol bios...

journal_title：Lipids

authors： Beynen AC,van der Molen AJ,Geelen MJ

更新日期：1981-06-01 00:00:00

abstract：:Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...

journal_title：Lipids

authors： Smith LL

更新日期：1996-05-01 00:00:00

abstract：:Plasma and liver lipids were studied in male weanling rats fed diets containing moderate levels of fat (6% by weight) as sunflower oil (SF diet, rich in linoleic acid), salmon oil (SM diet, rich in long-chain n-3 fatty acids), or a blend of peanut and rapeseed oil (PR diet, rich in oleic acid). After nine weeks of fee...

journal_title：Lipids

authors： Frémont L,Gozzelino MT

更新日期：1996-08-01 00:00:00

abstract：:The ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic ga...

journal_title：Lipids

authors： Prokazova NV,Bergelson LD

更新日期：1994-01-01 00:00:00

abstract：:If an increased consumption of alpha-linolenic acid (ALA) is to be promoted in parallel with that of n-3 long-chain-rich food, it is necessary to consider to what extent dietary ALA can be absorbed, transported, stored, and converted into long-chain derivatives. We investigated these processes in male hamsters, over a...

journal_title：Lipids

authors： Morise A,Combe N,Boué C,Legrand P,Catheline D,Delplanque B,Fénart E,Weill P,Hermier D

更新日期：2004-04-01 00:00:00

abstract：:Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...

journal_title：Lipids

authors： Wei DH,Zhang XL,Wang R,Zeng JF,Zhang K,Yang J,Li S,Lin XL,Jiang ZS,Wang GX,Wang Z

更新日期：2013-06-01 00:00:00

abstract：:The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...

journal_title：Lipids

authors： Zhang B,Shimoji E,Tanaka H,Saku K

更新日期：2003-03-01 00:00:00

abstract：:The present studies tested the hypothesis that some effects of tumor necrosis factor-alpha (TNF-alpha) are mediated by activation of sphingomyelinases and the production of ceramides. Differentiated 3T3-L1 adipocytes were incubated with short-chain ceramide analogs, (C2- and C6-ceramides: N-acetyl- and N-hexanoyl-sphi...

journal_title：Lipids

authors： Brindley DN,Wang CN,Mei J,Xu J,Hanna AN

更新日期：1999-01-01 00:00:00

abstract：:Racemic cis-9,10-epoxystearic acid was isolated from total lipids of human leukocytes. Identification of the epoxy acid was based mainly on gas liquid chromatographic-mass spectrometric analysis and on its chemical conversion into threo-9,10-dihydroxystearic acid. A mass spectrometric method for quantitative determina...

journal_title：Lipids

authors： Fahlstadius P

更新日期：1988-11-01 00:00:00

abstract：:The diglyceride species of phosphatidylcholines from livers of male rats after treatment of the animals with ethionine (1 mg/g divided among 4 doses 2 hr apart), phenobarbital (80 mg/kg each day for 3 days), or a combination of the two drugs were determined using gas chromatography. Ethionine treatment greatly elevate...

journal_title：Lipids

authors： Dyer RA,Klopfenstein WE

更新日期：1977-11-01 00:00:00

abstract：:The artificial rearing model was used to investigate the effects of short-term exposure to ethanol on growth and fatty acid composition of forebrain (FB) and cerebellum (CB) during the brain growth spurt in either n-3 fatty acid-adequate (AD) or n-3 deficient (DEF) rat pups. On postnatal day 5, offspring of female rat...

journal_title：Lipids

authors： Ward GR,Xing HC,Wainwright PE

更新日期：1999-11-01 00:00:00

abstract：:The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the ...

journal_title：Lipids

authors： Tang X,Ma H,Zou S,Chen W

更新日期：2007-11-01 00:00:00

abstract：:It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased ...

journal_title：Lipids

authors： Wolf A,Saito T,Dudek R,Bing RJ

更新日期：1991-03-01 00:00:00

abstract：:A systematic study of the influence of biological lipid peroxidation conditions on lipid hydroperoxide decomposition to thiobarbituric acid-reactive malondialdehyde is presented. A superoxide-dependent, iron-catalyzed peroxidation system was employed with xanthine oxidase plus hypoxanthine plus ferric iron-adenosine d...

journal_title：Lipids

authors： Janero DR,Burghardt B

更新日期：1989-02-01 00:00:00