Abstract:
:The ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic gangliosides in platelet activation and adhesion of platelets to the vessel wall. The effect of gangliosides on the structure of low density lipoproteins (LDL), on the interaction of LDL with macrophages and hepatic cells and on the LDL-regulated biosynthesis of cholesterol is also discussed. In vitro experiments have demonstrated that a major ganglioside of the intima of atherosclerotic aorta induces rapid adhesion, aggregation and spreading of platelets. Moreover, gangliosides present in elevated amounts in the intercellular space of atherosclerotic aortic tissue modify the surface structure and stimulate aggregation of LDL. Ganglioside-modified LDL are readily recognized and taken up by macrophages, while preincubation of LDL with low concentrations of gangliosides inhibits LDL binding to hepatic cells. Thus, ganglioside enrichment of LDL is likely to interfere with LDL clearance via the hepatic cells. Thus, ganglioside enrichment of LDL is likely to interfere with LDL clearance via the hepatic LDL receptor, and to stimulate binding of LDL to the scavenger receptor of macrophages. It is postulated that high ganglioside levels in the aorta and serum may be an additional risk factor in atherosclerosis.
journal_name
Lipidsjournal_title
Lipidsauthors
Prokazova NV,Bergelson LDdoi
10.1007/BF02537083subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1-5issue
1eissn
0024-4201issn
1558-9307journal_volume
29pub_type
杂志文章,评审相关文献
LIPIDS文献大全abstract::Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300% with each diet. Changes in serum concentrations of Sf 20+ and Sf 0-20 lip...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533395
更新日期:1978-03-01 00:00:00
abstract::Separation of thecis- andtrans-isomers of 1,2-benzylidene glyceryl esters has not yet been achieved by column or gas liquid chromatography. However these isomers were separated by thin layer chromatography in the present study and the parent cyclic alcohols regenerated by alkaline hydrolysis. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531768
更新日期:1973-08-01 00:00:00
abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3027-7
更新日期:2007-03-01 00:00:00
abstract::The mechanism of the self-assembly of the lamellar structure of natural stratum corneum lipids (SCL) has been a subject of considerable interest. We have examined this question by using a synthetic pseudo-ceramide (sphingolipid E, SLE) which was analogous to the naturally occurring ceramide type 2. The thermotropic pr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536040
更新日期:1995-04-01 00:00:00
abstract::The aim of the present study was to develop a cell culture system for studying the proliferation and differentiation of preadipocytes isolated from Atlantic salmon adipose tissue. The expression of proliferating cell nuclear antigen (PCNA) was used as a marker for cell proliferation. The cells started to proliferate w...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1063-3
更新日期:2003-03-01 00:00:00
abstract::The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9,trans-11 CLA (9c,11 tCLA); trans-10,cis-12 CLA (10t,12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic hamsters. One hundred ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5068-8
更新日期:2006-01-01 00:00:00
abstract::Approximately 20% of the phosphatidylglycerol of the lung tissue of several animals was found to have both fatty acids saturated. Pulmonary washings from the lung of the rabbit and guinea pig had more saturated phosphatidylglycerol than the washed lung tissue. Lung-saturated phosphatidylglycerol was relatively low in ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533529
更新日期:1979-06-01 00:00:00
abstract::The separation of lecithin derivatives based on their fatty acid substituents has been investigated. Several synthetic and natural lecithins were converted to their corresponding dimethylphosphatidates by hydrolysis with phospholipase D (phosphatidylcholine phospholipase D (phosphatidylcholine phosphatidohydrolase, EC...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532546
更新日期:1966-11-01 00:00:00
abstract::Docosahexaenoic acid (DHA), a prominent long-chain fatty acid of the omega-3 family, is present at high amount in brain tissues, especially in membrane phospholipids. This polyunsaturated fatty acid is the precursor of various oxygenated lipid mediators involved in diverse physiological and pathophysiological processe...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12006
更新日期:2018-01-01 00:00:00
abstract::The purpose of the study was to compare the polyunsaturated fatty acid (PUFA) status in patients with X-linked adrenoleukodystrophy or adrenomyeloneuropathy (X-ALD/AMN) with that in disorders of peroxisome biogenesis (PB). Total fatty acids and plasmalogens were quantified in plasma and red cells from 28 patients with...
journal_title:Lipids
pub_type: 杂志文章,多中心研究
doi:10.1007/BF02536332
更新日期:1994-04-01 00:00:00
abstract::Fatty acid synthetase purified (20 times) from lactating bovine mammary tissue had an approximate mot wt of 485,000. The enzyme had a high content of acidic and hydrophobic amino acid residues; 62±4 sulhydryl groups and one 4' phosphopantetheine residue/mole of enzyme. The enzyme was relatively stable when stored (3 m...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532485
更新日期:1975-04-01 00:00:00
abstract::Normal phase high performance liquid chromatography methods are described for the separation of neutral lipid, fatty acid and five phospholipid classes using spectrophotometric detection at 206 nm. Separations were accomplished in less than 10 min for each lipid class. A mobile phase consisting of hexane/methyltertiar...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535282
更新日期:1988-12-01 00:00:00
abstract::A lactoperoxidase/H2O2/halide system caused the initiation of linoleate peroxidation as indicated by diene conjugation. Coupled lipid peroxidation was accelerated by iodide, chloride and bromide ions at pH 4.0 and 6.2. No peroxidation occurred in the presence of H2O2 or lactoperoxidase alone. The rate of linoleate per...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534549
更新日期:1983-03-01 00:00:00
abstract::Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-010-3451-y
更新日期:2010-09-01 00:00:00
abstract::The composition of the glycosphingolipids of the human gastrointestinal tract was studied. The major neutral glycosphingolipids were ceramide monohexosides (e.g., GalCer, GlcCer), LacCer, Gb3Cer, Gb4Cer and more polar ones with more than four sugars, whereas neither Gg3Cer nor Gg4Cer were present. The acidic glycosphi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535996
更新日期:1993-08-01 00:00:00
abstract::The aim of this study was to develop a simple method for simultaneous determination of selected cis/cis PUFA-LNA (18:2), ALA (18:3), GLA (18:3), EPA (20:5), and DHA (22:6) by silver ion high-performance liquid chromatography coupled to a diode array detector (Ag-HPLC-DAD). The separation was performed on three Luna SC...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4133-1
更新日期:2016-04-01 00:00:00
abstract::The contents and compositions of the 1-O-alk-1'-enyl-2-acyl, 1-O-alkyl-2-acyl, and 1,2-diacyl glycerophospholipids in the muscle and viscera of the ascidian Halocynthia roretzi, and of the gonad of the sea urchin Strongylocentrotus intermedius, which are eaten to some extent in Alaska and in Asia, were analyzed by gas...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522404
更新日期:1996-01-01 00:00:00
abstract::The effects of aging on the hepatic metabolism of cholesterol were studied in 1-, 6- and 24-month-old male Sprague-Dawley rats. Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity, which regulates cholesterol biosynthesis, decreased from 835 +/- 144 (SEM) pmol/min/mg protein in the youngest g...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537197
更新日期:1991-05-01 00:00:00
abstract::Total lipid content in the thermophilic fungi-Thermoascus aurantiacus, Humicola lanuginosa, Malbranchea pulchella var.sulfurea, andAbsidia ramosa-varied from 5.3 to 19.1% of mycelial dry weight. The neutral and polar lipid fractions accounted for 56.4 to 80.2% and 19.8 to 43.6%, respectively. All the fungi contained m...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533048
更新日期:1976-10-01 00:00:00
abstract::Cis-9-conjugated, trans-11-conjugated linoleic acid (CLA) is known for its positive activities on human health. The synthesis of cis-9, trans-11 CLA in mammary glands is generally thought to be catalyzed by stearoyl-CoA desaturase 1 (SCD1), but this has not been rigorously established. In this study, we hypothesized t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12077
更新日期:2018-06-01 00:00:00
abstract::In their diversity, speciation, and sheer numerical superiority, few should question that insects are the dominant life-form on earth. Their utilization of the multifunctional isopentenoids to regulate their life processes is equally diverse. To catalog or even summarize the contribution of isopentenoids in the regula...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533754
更新日期:1978-10-01 00:00:00
abstract::Considerable progress has been made in the selection and characterization of mutants that are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae. Mutations in nearly every step of the yeast sterol biosynthetic pathway have been induced and selected. These mutants have been used to elucidat...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02537825
更新日期:1995-03-01 00:00:00
abstract::The pulp from unerupted calves' teeth was found to contain low levels of glycerol ester hydrolase activity. Solutions in Tris buffer cleared tributyrylglycerol agar and hydrolyzed emulsified olive oil. The average quantity of free fatty acids released in five assays with olive oil was: 2.8, S.D.+/-1.4. Specific activi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533302
更新日期:1977-02-01 00:00:00
abstract::New methods and analytical approaches are important to challenge and/or validate established beliefs in any field including the metabolism of polyunsaturated fatty acids (PUFA; polyunsaturates). Four methods that have recently been applied toward obtaining a better understanding of the homeostasis of PUFA include the ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-001-0808-3
更新日期:2001-09-01 00:00:00
abstract::This study was carried out to investigate the effects of a dietary oxidized oil on lipid metabolism in rats, particularly the desaturation of fatty acids. Two groups of rats were fed initially for a period of 35 d diets containing 10% of either fresh oil or thermally treated oil (150 degrees C, 6 d). The dietary fats ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0418-0
更新日期:1999-07-01 00:00:00
abstract::The gut microbiota is proposed as a "metabolic organ" involved in energy utilization and is associated with obesity. Dietary intervention is one of the approaches for obesity management. Changes in dietary components have significant impacts on host metabolism and gut microbiota. In the present study, we examined the ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4253-2
更新日期:2017-06-01 00:00:00
abstract::Stearoyl-coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. Recently, SCD1 down-regulation has been implicated in the prevention of obesity, and the improvement of insulin and leptin sensitivity. In this study, we examined...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3784-4
更新日期:2013-05-01 00:00:00
abstract::Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3889-4
更新日期:2014-05-01 00:00:00
abstract::The rare phospholipid fatty acids 3,7,11-trimethyldodecanoic (1), 5,9-hexadecadienoic (2) and 12-methyl-hexadecanoic (3) were identified in the marine spongeXestospongia muta. Branched fatty acids inX. muta accounted for 35% of the total fatty acid mixture. It was observed that the occurrence of the 5,9-hexadecadienoi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535668
更新日期:1988-07-01 00:00:00
abstract::The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533962
更新日期:1995-09-01 00:00:00