Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells.

Abstract:

:Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and trilinolein, upon oxidized low-density lipoprotein -induced oxidative stress was undertaken. Results indicated that trilinolein (78 % ± 0.02) and triolein (90 % ± 0.01) increased cell viability of endothelial cells exposed to oxidized low-density lipoprotein, whereas tristearin decreased the cell viability (55 % ± 0.03) (P < 0.05). Oxidized low-density lipoprotein treatment significantly increased apoptosis (23 %), compared to cells simultaneously exposed to trilinolein (19 %) or triolein (16 %), where apoptosis was reduced (P < 0.05). On the other hand, exposure to tristearin further increased oxidized low-density lipoprotein -induced cell apoptosis (34 %). Treatment with trilinolein or triolein on oxidized low-density lipoprotein -stimulated endothelial cells inhibited the expression of ICAM-1 and E-selectin mRNA. Moreover, both trilinolein and triolein demonstrated a strong antioxidant response to oxidative stress caused by oxidized low-density lipoprotein. Taken together, the results indicate trilinolein and triolein possess anti-inflammatory properties, which are mediated via the antioxidant defense system.

journal_name

Lipids

journal_title

Lipids

authors

Luo T,Deng ZY,Li XP,Rao H,Fan YW

doi

10.1007/s11745-014-3889-4

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

495-504

issue

5

eissn

0024-4201

issn

1558-9307

journal_volume

49

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapy.

    abstract::Policosanol is a poorly absorbed nutritional supplement used primarily for cholesterol management. Findings from previous trials evaluating the effects of policosanol are mixed with early data reporting positive lipid effects while more recent studies indicate negligible efficacy. We hypothesized that re-formulating p...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-011-3591-8

    authors: Backes JM,Gibson CA,Ruisinger JF,Moriarty PM

    更新日期:2011-10-01 00:00:00

  • Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes.

    abstract::The beneficial roles of dietary fish oil in lowering serum TAG levels in animals and humans have been attributed in part to the high content of two n-3 polyunsaturated very long-chain FA, EPA, and DHA. Recent studies show that EPA induces mitochondrial beta-oxidation in hepatocytes, which might contribute to the syste...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1443-8

    authors: Guo W,Xie W,Lei T,Hamilton JA

    更新日期:2005-08-01 00:00:00

  • Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development.

    abstract::The reciprocal replacement of DHA by docosapentaenoic acid (DPAn-6) was studied in rats that consumed an n-3 FA-deficient or n-3 FA-adequate diet. Dams were fed the two experimental diets from weaning and throughout pregnancy and lactation. Their pups were then fed the respective diets after weaning. Cortex FA analysi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-003-1080-2

    authors: Greiner RS,Catalan JN,Moriguchi T,Salem N Jr

    更新日期:2003-04-01 00:00:00

  • Lipase-catalyzed hydrolysis of TG containing acetylenic FA.

    abstract::Hydrolysis of symmetrical acetylenic TG of type AAA [viz., glycerol tri-(4-decynoate), glycerol tri-(6-octadecynoate), glycerol tri-(9-octadecynoate), glycerol tri-(10-undecynoate), and glycerol tri-(13-docosynoate)] in the presence of eight microbial lipases was studied. Novozyme 435 (Candida antarctica), an efficien...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-0992-1

    authors: Jie MS,Fua X,Lau MM,Chye ML

    更新日期:2002-10-01 00:00:00

  • Fatty Acid Profile of Pacific Oyster, Crassostrea gigas, Fed Different Ratios of Dietary Seaweed and Microalgae during Broodstock Conditioning.

    abstract::The fatty acid (FA) profile of oysters generally reflects the dietary FA composition. Moreover, incorporation of FA into tissues is modulated by various metabolic factors, and final composition will depend upon the dietary sources, cumulative intake, and oysters' development stage. Thus, the aim of this study was to a...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12177

    authors: Rato A,Pereira LF,Joaquim S,Gomes R,Afonso C,Cardoso C,Machado J,Gonçalves JFM,Vaz-Pires P,Magnoni LJ,Matias AM,Matias D,Bandarra NM,Ozório ROA

    更新日期:2019-09-01 00:00:00

  • Cardiopathogenicity of rapeseed oils and oil blends differing in erucic, linoleic, and linolenic acid content.

    abstract::Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532900

    authors: McCutcheon JS,Umermura T,Bhatnager MK,Walker BL

    更新日期:1976-07-01 00:00:00

  • Epoxidation reactions of unsaturated fatty esters with potassium peroxomonosulfate.

    abstract::Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0250-6

    authors: Lie Ken Jie MS,Pasha MK

    更新日期:1998-06-01 00:00:00

  • Modeling of alpha-tocopherol loss and oxidation products formed during thermoxidation in triolein and tripalmitin mixtures.

    abstract::The degradation of alpha-tocopherol and the formation of alpha-tocopherol and triacylglycerol oxidation products at high temperatures (150-250 degrees C) over a heating period (0-4 h) for a model system ranging between triolein and tripalmitin were modeled by use of an experimental design. The oxidation products of al...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0777-6

    authors: Verleyen T,Kamal-Eldin A,Dobarganes C,Verhe R,Dewettinck K,Huyghebaert A

    更新日期:2001-07-01 00:00:00

  • Activation of the phospholipase A1 activity of lipoprotein lipase by apoprotein C-II.

    abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02540967

    authors: Stocks J,Galton DJ

    更新日期:1980-03-01 00:00:00

  • The lipid components of white potato tubers (Solanum tuberosum).

    abstract::Four Canadian varieties of potatoes were examined for their lipid composition. Lipids, extracted with chloroformmethanol, were shown by TLC and column chromatography to consist of 16.5% neutral lipids, 45.5% phospholipids and 38.1% glycolipids. Among the phospholipids and glycolipids, phosphatidyl choline, phosphatidy...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02530889

    authors: Lepage M

    更新日期:1968-11-01 00:00:00

  • Gender and dietary fat affect alpha-tocopherol status in F344/N rats.

    abstract::For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleate in all diets. Females had greater mean hepatic alpha-tocopherol levels, whereas males had greater plasma alp...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535861

    authors: Chen HW,Cook LR,Hendrich S

    更新日期:1992-11-01 00:00:00

  • Analysis of volatile fatty acids in biological specimens by capillary column gas chromatography.

    abstract::A method was developed to analyze and quantify volatile fatty acids (VFA) such as acetic, propionic, butyric, isobutyric, valeric and isovaleric acids in biological specimens. To obtain good sample transfer into the chromatographic system an organic solvent had to be used together with an aqueous milieu, thus improvin...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537302

    authors: Fleming SE,Traitler H,Koellreuter B

    更新日期:1987-03-01 00:00:00

  • Effect of human mammary MX-1 tumor on plasma free fatty acids in fasted and fasted-refed nude mice.

    abstract::We hypothesized that tumor-bearing (TB) nude mice, because they are reported to have no detectable, circulating tumor necrosis factor (TNF)/cachectin, would regulate their plasma free fatty acid (FFA) levels normally when fasted and refed. We compared levels of individual plasma FFA in response to fasting (24 hr) and ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537055

    authors: Lin C,Blank W,Ceriani RL,Baker N

    更新日期:1992-01-01 00:00:00

  • Polyunsaturated phosphatidylinositol and diacylglycerol substantially modify the fluidity and polymorphism of biomembranes: a solid-state deuterium NMR study.

    abstract::One of the main biological systems that can be used as a model for studying the molecular mechanisms involved in membrane fusion is the formation of the nuclear envelope (NE). NE assembly to form the male pronucleus at fertilization occurs by binding of NE membrane precursor vesicles to chromatin and their fusion. MV1...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-5045-2

    authors: Larijani B,Dufourc EJ

    更新日期:2006-10-01 00:00:00

  • Changes in liver fatty acid unsaturation after partial hepatectomy in the rat.

    abstract::The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsatura...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-543-9

    authors: Kishino T,Tanno M,Yamada H,Saito S,Matsumoto S

    更新日期:2000-04-01 00:00:00

  • Acetate treatment increases fatty acid content in LPS-stimulated BV2 microglia.

    abstract::Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3911-x

    authors: Bhatt DP,Rosenberger TA

    更新日期:2014-07-01 00:00:00

  • Lipolysis of corn, peanut and randomized peanut oils.

    abstract::Corn oil, peanut oil and randomized peanut oil exhibit different atherogenic potentials; peanut oil being more atherogenic than the other oils. This study was conducted to ascertain if the atherogenicity of these oils was related to their rates of lipolysis. Using both pancreatic lipase and milk lipoprotein lipase (LP...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534645

    authors: Kim HK,Kritchevsky D

    更新日期:1983-11-01 00:00:00

  • Ionic liquids increase the catalytic efficiency of a lipase (Lip1) from an antarctic thermophilic bacterium.

    abstract::Lipases catalyze the hydrolysis and synthesis of triglycerides and their reactions are widely used in industry. The use of ionic liquids has been explored in order to improve their catalytic properties. However, the effect of these compounds on kinetic parameters of lipases has been poorly understood. A study of the k...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3973-9

    authors: Muñoz PA,Correa-Llantén DN,Blamey JM

    更新日期:2015-01-01 00:00:00

  • Fatty acid-specific, regiospecific, and stereospecific hydroxylation by cytochrome P450 (CYP152B1) from Sphingomonas paucimobilis: substrate structure required for alpha-hydroxylation.

    abstract::Fatty acid alpha-hydroxylase from Sphingomonas paucimobilis is an unusual cytochrome P450 enzyme that hydroxylates the alpha-carbon of fatty acids in the presence of H2O2. Herein, we describe our investigation concerning the utilization of various substrates and the optical configuration of the alpha-hydroxyl product ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-533-y

    authors: Matsunaga I,Sumimoto T,Ueda A,Kusunose E,Ichihara K

    更新日期:2000-04-01 00:00:00

  • Effects of growth temperature on the fatty acid composition of the free-living nematode Caenorhabditis elegans.

    abstract::The effects of growth temperature on the fatty acid compositions of the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and total lipid (TL) fractions of the free-living nematode Caenorhabditis elegans were investigated. A reduction in growth temperature from 25 to 15 degrees C caused the proportions of eicos...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02524292

    authors: Tanaka T,Ikita K,Ashida T,Motoyama Y,Yamaguchi Y,Satouchi K

    更新日期:1996-11-01 00:00:00

  • The effect of an energy restricted low glycemic index diet on blood lipids, apolipoproteins and lipoprotein (a) among adolescent girls with excess weight: a randomized clinical trial.

    abstract::Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an L...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-013-3834-y

    authors: Rouhani MH,Kelishadi R,Hashemipour M,Esmaillzadeh A,Azadbakht L

    更新日期:2013-12-01 00:00:00

  • Cholesteryl esterase activities in ventricles, isolated heart cells and aorta of the rat.

    abstract::Cholesteryl esterase activities were determined in homogenates of rat heart (ventricles), isolated, calcium-tolerant, cardiac myocytes and aortic tissue and were compared with acid and neutral triglyceride lipase activities in these fractions. Using cholesteryl oleate/phosphatidylcholine/taurocholate emulsions and dig...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534862

    authors: Stam H,Broekhoven-Schokker S,Schoonderwoerd K,Hülsmann WC

    更新日期:1987-02-01 00:00:00

  • Olive oil consumption and reduced incidence of hypertension: the SUN study.

    abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-004-1352-x

    authors: Alonso A,Martínez-González MA

    更新日期:2004-12-01 00:00:00

  • Apolipoprotein E polymorphism: automated determination of apolipoprotein E2, E3, and E4 isoforms.

    abstract::Apolipoprotein E (apo E) plays an essential role in lipoprotein metabolism, where it is involved in the clearance of chylomicrons and very low density lipoproteins. Apart from some rare variants, apo E exists in three common isoforms (E2, E3, and E4). The different isoforms have not only been associated with different...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0500-7

    authors: Wiebe C,Holzem G,Wielckens K,Klingler KR

    更新日期:2000-01-01 00:00:00

  • Impact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse Hepatocytes.

    abstract::Liver fatty-acid-binding protein (FABP1, L-FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Although FABP1 regulates hepatic uptake and metabolism of ARA, almost not...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12071

    authors: McIntosh AL,Huang H,Landrock D,Martin GG,Li S,Kier AB,Schroeder F

    更新日期:2018-06-01 00:00:00

  • The role of n-3 essential fatty acids in brain and behavioral development: a cross-fostering study in the mouse.

    abstract::A cross-fostering design was used to examine the effects on brain and behavioral development in mice of pre- and/or postnatal dietary supplementation with n-3 fatty acids. Pregnant mice were fed either of two liquid diets, control (con) or experimental (exp). Each diet provided 3% of the calories in the form of n-6 fa...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544022

    authors: Wainwright PE,Huang YS,Bulman-Fleming B,Mills DE,Redden P,McCutcheon D

    更新日期:1991-01-01 00:00:00

  • Quantitative 31P nuclear magnetic resonance analysis of the phospholipids of erythrocyte membranes using detergent.

    abstract::31P Nuclear magnetic resonance (NMR) spectra of human erythrocyte lysates dissolved in sodium cholate were acquired. The narrow resonances of phospholipids were mostly well resolved, allowing identification and accurate quantitative analysis of phospholipid classes of the erythrocyte membranes. The ether-linked phosph...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522893

    authors: Nouri-Sorkhabi MH,Wright LC,Sullivan DR,Kuchel PW

    更新日期:1996-07-01 00:00:00

  • Membrane fatty acids as pacemakers of animal metabolism.

    abstract::The recent discovery that the fatty acid composition of tissue phospholipids varies in a systematic manner among species has lead to the proposal that membrane fatty acid composition is an important determinant of the metabolic rate characteristic for each species. Endotherms (mammals and birds) have a basal metabolic...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-007-3058-0

    authors: Hulbert AJ

    更新日期:2007-09-01 00:00:00

  • Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender.

    abstract::Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition inte...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-5064-z

    authors: Ogborn MR,Nitschmann E,Bankovic-Calic N,Weiler HA,Aukema HM

    更新日期:2006-12-01 00:00:00

  • Effects of soy or milk protein during a high-fat feeding challenge on oxidative stress, inflammation, and lipids in healthy men.

    abstract::Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to determine if 39 g soy (85 mg aglycone isoflavones, treatment) compar...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-006-5095-5

    authors: Campbell CG,Brown BD,Dufner D,Thorland WG

    更新日期:2006-03-01 00:00:00