Abstract:
:Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and trilinolein, upon oxidized low-density lipoprotein -induced oxidative stress was undertaken. Results indicated that trilinolein (78 % ± 0.02) and triolein (90 % ± 0.01) increased cell viability of endothelial cells exposed to oxidized low-density lipoprotein, whereas tristearin decreased the cell viability (55 % ± 0.03) (P < 0.05). Oxidized low-density lipoprotein treatment significantly increased apoptosis (23 %), compared to cells simultaneously exposed to trilinolein (19 %) or triolein (16 %), where apoptosis was reduced (P < 0.05). On the other hand, exposure to tristearin further increased oxidized low-density lipoprotein -induced cell apoptosis (34 %). Treatment with trilinolein or triolein on oxidized low-density lipoprotein -stimulated endothelial cells inhibited the expression of ICAM-1 and E-selectin mRNA. Moreover, both trilinolein and triolein demonstrated a strong antioxidant response to oxidative stress caused by oxidized low-density lipoprotein. Taken together, the results indicate trilinolein and triolein possess anti-inflammatory properties, which are mediated via the antioxidant defense system.
journal_name
Lipidsjournal_title
Lipidsauthors
Luo T,Deng ZY,Li XP,Rao H,Fan YWdoi
10.1007/s11745-014-3889-4subject
Has Abstractpub_date
2014-05-01 00:00:00pages
495-504issue
5eissn
0024-4201issn
1558-9307journal_volume
49pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Policosanol is a poorly absorbed nutritional supplement used primarily for cholesterol management. Findings from previous trials evaluating the effects of policosanol are mixed with early data reporting positive lipid effects while more recent studies indicate negligible efficacy. We hypothesized that re-formulating p...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-011-3591-8
更新日期:2011-10-01 00:00:00
abstract::The beneficial roles of dietary fish oil in lowering serum TAG levels in animals and humans have been attributed in part to the high content of two n-3 polyunsaturated very long-chain FA, EPA, and DHA. Recent studies show that EPA induces mitochondrial beta-oxidation in hepatocytes, which might contribute to the syste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1443-8
更新日期:2005-08-01 00:00:00
abstract::The reciprocal replacement of DHA by docosapentaenoic acid (DPAn-6) was studied in rats that consumed an n-3 FA-deficient or n-3 FA-adequate diet. Dams were fed the two experimental diets from weaning and throughout pregnancy and lactation. Their pups were then fed the respective diets after weaning. Cortex FA analysi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1080-2
更新日期:2003-04-01 00:00:00
abstract::Hydrolysis of symmetrical acetylenic TG of type AAA [viz., glycerol tri-(4-decynoate), glycerol tri-(6-octadecynoate), glycerol tri-(9-octadecynoate), glycerol tri-(10-undecynoate), and glycerol tri-(13-docosynoate)] in the presence of eight microbial lipases was studied. Novozyme 435 (Candida antarctica), an efficien...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-0992-1
更新日期:2002-10-01 00:00:00
abstract::The fatty acid (FA) profile of oysters generally reflects the dietary FA composition. Moreover, incorporation of FA into tissues is modulated by various metabolic factors, and final composition will depend upon the dietary sources, cumulative intake, and oysters' development stage. Thus, the aim of this study was to a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12177
更新日期:2019-09-01 00:00:00
abstract::Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532900
更新日期:1976-07-01 00:00:00
abstract::Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0250-6
更新日期:1998-06-01 00:00:00
abstract::The degradation of alpha-tocopherol and the formation of alpha-tocopherol and triacylglycerol oxidation products at high temperatures (150-250 degrees C) over a heating period (0-4 h) for a model system ranging between triolein and tripalmitin were modeled by use of an experimental design. The oxidation products of al...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0777-6
更新日期:2001-07-01 00:00:00
abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02540967
更新日期:1980-03-01 00:00:00
abstract::Four Canadian varieties of potatoes were examined for their lipid composition. Lipids, extracted with chloroformmethanol, were shown by TLC and column chromatography to consist of 16.5% neutral lipids, 45.5% phospholipids and 38.1% glycolipids. Among the phospholipids and glycolipids, phosphatidyl choline, phosphatidy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02530889
更新日期:1968-11-01 00:00:00
abstract::For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleate in all diets. Females had greater mean hepatic alpha-tocopherol levels, whereas males had greater plasma alp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535861
更新日期:1992-11-01 00:00:00
abstract::A method was developed to analyze and quantify volatile fatty acids (VFA) such as acetic, propionic, butyric, isobutyric, valeric and isovaleric acids in biological specimens. To obtain good sample transfer into the chromatographic system an organic solvent had to be used together with an aqueous milieu, thus improvin...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537302
更新日期:1987-03-01 00:00:00
abstract::We hypothesized that tumor-bearing (TB) nude mice, because they are reported to have no detectable, circulating tumor necrosis factor (TNF)/cachectin, would regulate their plasma free fatty acid (FFA) levels normally when fasted and refed. We compared levels of individual plasma FFA in response to fasting (24 hr) and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537055
更新日期:1992-01-01 00:00:00
abstract::One of the main biological systems that can be used as a model for studying the molecular mechanisms involved in membrane fusion is the formation of the nuclear envelope (NE). NE assembly to form the male pronucleus at fertilization occurs by binding of NE membrane precursor vesicles to chromatin and their fusion. MV1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5045-2
更新日期:2006-10-01 00:00:00
abstract::The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsatura...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-543-9
更新日期:2000-04-01 00:00:00
abstract::Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3911-x
更新日期:2014-07-01 00:00:00
abstract::Corn oil, peanut oil and randomized peanut oil exhibit different atherogenic potentials; peanut oil being more atherogenic than the other oils. This study was conducted to ascertain if the atherogenicity of these oils was related to their rates of lipolysis. Using both pancreatic lipase and milk lipoprotein lipase (LP...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534645
更新日期:1983-11-01 00:00:00
abstract::Lipases catalyze the hydrolysis and synthesis of triglycerides and their reactions are widely used in industry. The use of ionic liquids has been explored in order to improve their catalytic properties. However, the effect of these compounds on kinetic parameters of lipases has been poorly understood. A study of the k...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3973-9
更新日期:2015-01-01 00:00:00
abstract::Fatty acid alpha-hydroxylase from Sphingomonas paucimobilis is an unusual cytochrome P450 enzyme that hydroxylates the alpha-carbon of fatty acids in the presence of H2O2. Herein, we describe our investigation concerning the utilization of various substrates and the optical configuration of the alpha-hydroxyl product ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-533-y
更新日期:2000-04-01 00:00:00
abstract::The effects of growth temperature on the fatty acid compositions of the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and total lipid (TL) fractions of the free-living nematode Caenorhabditis elegans were investigated. A reduction in growth temperature from 25 to 15 degrees C caused the proportions of eicos...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02524292
更新日期:1996-11-01 00:00:00
abstract::Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an L...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-013-3834-y
更新日期:2013-12-01 00:00:00
abstract::Cholesteryl esterase activities were determined in homogenates of rat heart (ventricles), isolated, calcium-tolerant, cardiac myocytes and aortic tissue and were compared with acid and neutral triglyceride lipase activities in these fractions. Using cholesteryl oleate/phosphatidylcholine/taurocholate emulsions and dig...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534862
更新日期:1987-02-01 00:00:00
abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-004-1352-x
更新日期:2004-12-01 00:00:00
abstract::Apolipoprotein E (apo E) plays an essential role in lipoprotein metabolism, where it is involved in the clearance of chylomicrons and very low density lipoproteins. Apart from some rare variants, apo E exists in three common isoforms (E2, E3, and E4). The different isoforms have not only been associated with different...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0500-7
更新日期:2000-01-01 00:00:00
abstract::Liver fatty-acid-binding protein (FABP1, L-FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Although FABP1 regulates hepatic uptake and metabolism of ARA, almost not...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12071
更新日期:2018-06-01 00:00:00
abstract::A cross-fostering design was used to examine the effects on brain and behavioral development in mice of pre- and/or postnatal dietary supplementation with n-3 fatty acids. Pregnant mice were fed either of two liquid diets, control (con) or experimental (exp). Each diet provided 3% of the calories in the form of n-6 fa...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544022
更新日期:1991-01-01 00:00:00
abstract::31P Nuclear magnetic resonance (NMR) spectra of human erythrocyte lysates dissolved in sodium cholate were acquired. The narrow resonances of phospholipids were mostly well resolved, allowing identification and accurate quantitative analysis of phospholipid classes of the erythrocyte membranes. The ether-linked phosph...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522893
更新日期:1996-07-01 00:00:00
abstract::The recent discovery that the fatty acid composition of tissue phospholipids varies in a systematic manner among species has lead to the proposal that membrane fatty acid composition is an important determinant of the metabolic rate characteristic for each species. Endotherms (mammals and birds) have a basal metabolic...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-007-3058-0
更新日期:2007-09-01 00:00:00
abstract::Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition inte...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5064-z
更新日期:2006-12-01 00:00:00
abstract::Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to determine if 39 g soy (85 mg aglycone isoflavones, treatment) compar...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-006-5095-5
更新日期:2006-03-01 00:00:00