Abstract：
:A cross-fostering design was used to examine the effects on brain and behavioral development in mice of pre- and/or postnatal dietary supplementation with n-3 fatty acids. Pregnant mice were fed either of two liquid diets, control (con) or experimental (exp). Each diet provided 3% of the calories in the form of n-6 fatty acids; the experimental diet was supplemented with an additional 1.5% from long chain n-3 fatty acids derived from fish oil. There were four treatment groups, with all pups fostered at birth. These groups were (prenatal diet/postnatal diet): Group 1. exp/exp; Group 2, exp/con; Group 3, con/exp; Group 4, con/con; a fifth control group (unfostered) was fed lab chow (LC) throughout the study. Animals from the exp/exp and con/con groups were weaned onto lab chow for later behavioral assessment. Prenatal n-3 supplementation resulted in a small acceleration of behavioral development. The adult animals did not differ on visual discrimination learning nor did they differ in visual acuity. During development the fatty acid composition of the brain membrane phospholipids reflected closely that of the pre- and postnatal dietary conditions. Levels of 22:5n-3 and 22:6n-3 increased in the n-3 supplemented groups, accompanied by a decrease in levels of 22:4n-6 and 22:5n-6; the net effect of these changes was to increase the total levels of C22 fatty acids. While these results support considerable plasticity of the fatty acid composition of the developing brain with respect to the immediate dietary availability of n-3 compounds, they do not support long term effects on learning capacity of n-3 supplementation during the developmental period.
journal_name
Lipidsjournal_title
Lipidsauthors
Wainwright PE,Huang YS,Bulman-Fleming B,Mills DE,Redden P,McCutcheon Ddoi
10.1007/BF02544022subject
Has Abstractpub_date
1991-01-01 00:00:00pages
37-45issue
1eissn
0024-4201issn
1558-9307journal_volume
26pub_type
杂志文章相关文献
LIPIDS文献大全abstract：:An unidentified bacterial strain, SCRC-21406, isolated from the intestine of a marine fish, Glossanodon semifasciatus, produced docosahexaenoic acid at 23% (mol/mol) [= 28% (w/w)] of total fatty acids in a medium containing 0.5% (wt/vol) peptone and 0.1% (wt/vol) yeast extract at 12 degrees C under atmospheric pressur...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-997-0127-8
更新日期：1997-09-01 00:00:00
abstract：:Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 hu...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-999-330-7
更新日期：1999-01-01 00:00:00
abstract：:The particular interest in supplementing human foods with n-3 fatty acids has arisen from the findings that this series of polyunsaturated fatty acids (PUFA) have an impact on neuronal functions. Indeed vertebrates, including humans, preferentially use docosahexaenoic acid (DHA, 22:6n-3) over other long-chain n-3 PUFA...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-012-3686-x
更新日期：2012-08-01 00:00:00
abstract：:Tetramethylammonium hydroxide has been used in the extraction and pyrolysis methylation of the carboxylic acids produced by periodate-permanganate oxidation of monounsaturated fatty acid methyl esters. This modification of the von Rudloff procedure allows rapid determination of double-bond positions and analysis of mi...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02530977
更新日期：1968-01-01 00:00:00
abstract：:The hypothesis that the essential oil from Tagetes minuta L. can interact with biological membranes was investigated by assessing its ability of perturbing the binding of a benzodiazepine [flunitrazepam (FNTZ)] to crude members from chick brains. The essential oil from T. minuta L. inhibited [3H]FNTZ specific binding ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536610
更新日期：1995-12-01 00:00:00
abstract：:The stereochemistry of fat digestion and absorption was investigated in rats with thoracic duct fistulas, after feeding synthetic triacylglycerol or alkyldiacylglycerol. After feeding 1,2-dilauroyl-3-oleoyl-sn-glycerol, dilauroyloleoylglycerol and lauroyldioleoylglycerol were the most abundant chyle triacylglycerols. ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533725
更新日期：1978-05-01 00:00:00
abstract：:The content and positional distribution of CLA in TAG fractions of lamb tissues was examined with either preformed CLA or the linoleic acid precursor of CLA in the diet as experimental treatments. The CLA content of phospholipid (PL) from these tissues was also examined. Thirteen lambs were randomized to the following...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-002-0939-6
更新日期：2002-06-01 00:00:00
abstract：:We describe a method for the quantitative analysis of molecular species of diacylglycerol and alkylacylglycerol as their diradylglycerobenzoate derivatives. Synthetic internal standards were used to provide quantitative determinations of the low levels of diacylglycerol and alkylacylglycerol and their individual molec...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02544045
更新日期：1990-11-01 00:00:00
abstract：:Hepatocytes isolated from rainbow trout fed on diets containing either fish oil or olive oil were incubated with individual odd-chain length unsaturated fatty acids (19:1n-9, 19:2n-6, 19:3n-3, 21:2n-6, 21:3n-6, 21:4n-6, 21:3n-3, and 21:5n-3) to examine whether these fatty acids were substrates for modification by desa...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-997-0078-0
更新日期：1997-06-01 00:00:00
abstract：:Membrane phospholipid (PL) composition has been shown to affect cellular function by altering membrane physical structure. The sarcolemma plasma membrane (SLpm) is integral to skeletal muscle function and health. Previous studies assessing SLpm PL composition have demonstrated contamination from transverse (t)-tubule,...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-013-3770-x
更新日期：2013-04-01 00:00:00
abstract：:Lipids from bovine optic nerve were analyzed. The total content of 16.5% by weight included 27.2% nonpolar lipids, 26.1% glycolipids, and 46.7% phospholipids by weight. Free cholesterol was the major component of the nonpolar lipid fraction. The cerebrosides, 73.5% of total glycolipids, were separated by thin layer ch...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533745
更新日期：1978-10-01 00:00:00
abstract：:There is convincing evidence that normal cultured human keratinocytes possess a 15-lipoxygenase activity which, however, does not appear to manifest itself without cell membrane damage. When "activated", this enzyme transforms arachidonic acid into 15-hydroxyeicosatetraenoic acid (15-HETE), and linoleic acid into 13-h...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536012
更新日期：1990-10-01 00:00:00
abstract：:The incorporation of arachidonic acid (AA) as compared to eicosapentaenoic acid (EPA) into human platelet phospholipids was tested by incubating washed platelets with a known mixture of [3H]AA and [14C]EPA. Following incubation, the platelet lipids were extracted, the individual phospholipids--phosphatidylcholine (PC)...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02534401
更新日期：1985-11-01 00:00:00
abstract：:The mechanism of the self-assembly of the lamellar structure of natural stratum corneum lipids (SCL) has been a subject of considerable interest. We have examined this question by using a synthetic pseudo-ceramide (sphingolipid E, SLE) which was analogous to the naturally occurring ceramide type 2. The thermotropic pr...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536040
更新日期：1995-04-01 00:00:00
abstract：:Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups a...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-016-4165-6
更新日期：2016-08-01 00:00:00
abstract：:The present study was performed to investigate the effect of dietary conjugated linoleic acid (CLA) on the growth performance, immune parameters and disease resistance to Aeromonas hydrophila of juvenile Jian carp. A total of 900 juvenile Jian carp (10.71 +/- 0.02 g) were randomly allocated into six groups of each thr...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-010-3425-0
更新日期：2010-06-01 00:00:00
abstract：:Although migrating birds use stored triacylglycerol as their primary fuel for flight, they must retain sufficient stores of omega 6 and omega 3 fatty acids to sustain reproduction after the spring migration. Hepatic monoacylglycerol:acyl-coenzyme A acyltransferase (EC 2.3.1.22) (MGAT) activity is associated with physi...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536701
更新日期：1994-11-01 00:00:00
abstract：:Several ions in the mass spectra of wax esters were related to the molecular structures. Assigned structures of ions were confirmed by deuterium labeling. A simple, direct method for quantititive analyses of mixtures was developed. The method involved a comparison of sets of three ions, RCO2H(+), RCO2H2 (+) and [R'-1]...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02531236
更新日期：1971-07-01 00:00:00
abstract：:The weight loss supplement conjugated linoleic acid (CLA) consists of an equal mixture of trans-10,cis-12 (10,12) and cis-9,trans-11 (9,11) isomers. However, high levels of mixed CLA isomers, or the 10,12 isomer, causes chronic inflammation, lipodystrophy, or insulin resistance. We previously demonstrated that 10,12 C...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-012-3711-0
更新日期：2012-11-01 00:00:00
abstract：:Water and lipid contents, fatty acid distribution, and lipoprotein lipase activity were determined in 11 samples taken from the Omentum Majus of five dry Alpine goats. Samples were chosen to standardize sampling sites using geometric guide marks representative of different adipose tissue sites. Sample location explain...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536391
更新日期：1992-06-01 00:00:00
abstract：:Oxidized LDL (oxLDL) has been shown to activate the sphingomyelinase pathway producing ceramide in vascular smooth muscle cells. Therefore ceramide, which is a biologically active lipid causing apoptosis in a variety of cells, may be involved in the apoptotic action of oxLDL. In this study, we examined whether cholest...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-007-3067-z
更新日期：2007-10-01 00:00:00
abstract：:The cytotoxicity of fatty acids from seed oils containing conjugated linolenic acids (CLN) was studied. Fatty acids from pomegranate, tung, and catalpa were cytotoxic to human monocytic leukemia cells at concentrations exceeding 5 microM for pomegranate and tung and 10 microM for catalpa, but fatty acids from pot mari...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-001-0746-0
更新日期：2001-05-01 00:00:00
abstract：:The effects of n-3 fatty acids on plasma lipids, lipoproteins and apoproteins have usually been studied in humans after feeding of purified fish oil. This study describes the effect of a natural diet, containing salmon as the source of n-3 fatty acids, on these parameters as compared to a diet very low in n-3 fatty ac...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02544001
更新日期：1991-02-01 00:00:00
abstract：:Fast atom bombardment-tandem mass spectrometry was used to identify molecular species of paf-acether (paf) produced by human polymorphonuclear neutrophils. Using this biological material, normal phase high performance liquid chromatography was necessary prior to the fast atom bombardment-tandem mass spectrometry step....
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02535248
更新日期：1989-02-01 00:00:00
abstract：:Because bile contains substantial amounts of cholesterol precursors, e.g., squalene and different methyl sterols, the fate of biliary squalene was studied by incubating isolated jejunal loops of the rat in vivo with bile containing 3H-squalene and 14C-cholesterol. After 90 min, no radioactivity was found in plasma lip...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02535392
更新日期：1983-08-01 00:00:00
abstract：:Two per thousand pregnant women have hyperthyroidism (HT), and although the symptoms are attenuated during pregnancy, they rebound after delivery, affecting infant development. To examine the effects of hyperthyroidism on lactation, we studied lipid metabolism in maternal mammary glands and livers of hyperthyroid rats...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-001-0787-4
更新日期：2001-08-01 00:00:00
abstract：:This review explores the effects of dietary long chain polyunsaturated fatty acids (LCPUFA) on various aspects of early immune development and their potential role in the development or the prevention of immune disease. Modern diets have become increasingly rich in n-6 LCPUFA and relatively n-3 LCPUFA deficient. These...
journal_title：Lipids
pub_type： 杂志文章,评审
doi：10.1007/s11745-007-3030-z
更新日期：2007-09-01 00:00:00
abstract：:The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-003-1053-5
更新日期：2003-03-01 00:00:00
abstract：:The purpose of this study was to compare fish intake and plasma phospholipid concentrations of n-3 fatty acids, in particular of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among representative population samples of Québecers, James Bay Cree, and Inuit of Nunavik (Canada). The relationships between the...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-003-1070-4
更新日期：2003-04-01 00:00:00
abstract：:The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CL...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-998-0236-4
更新日期：1998-05-01 00:00:00
