Atherogenesis in swine fed several types of lipid-cholesterol diets.

Abstract:

:Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300% with each diet. Changes in serum concentrations of Sf 20+ and Sf 0-20 lipoproteins varied with diets fed. Serum concentration of high density lipoprotein was increased in all cases. Intima concentration of Sf 0-20 lipoprotein fraction was elevated by feeding the corn oil diet. There was no development of atherosclerosis as a result of feeding the corn oil-cholesterol diet, but there was an increase in atherosclerosis as a result of feeding the lard or coconut oil diet. There were no correlations between fatty acid patterns of several lipid fractions from serum and corresponding lipid fractions from aortic intima of corn oil fed animals.

journal_name

Lipids

journal_title

Lipids

authors

Goldsmith DP,Jacob HP

doi

10.1007/BF02533395

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

174-80

issue

3

eissn

0024-4201

issn

1558-9307

journal_volume

13

pub_type

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