Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats.

abstract：:A test meal (300 mg casein, 600 mg sucrose, 100 mg corn oil, tracer dose of 9.10(3)H oleic acid) was given to fasting adult rats with intestinal lymph fistulas. One group received an acute oral dose of ethanol (3.2 g/kg body weight) simultaneously with the test meal. Controls received 2.5 ml of water instead of ethano...

journal_title：Lipids

authors： Boquillon M

更新日期：1976-12-01 00:00:00

abstract：:The physiological role of long-chain fatty acyl-CoA is thought to be primarily in intermediary metabolism of fatty acids. However, recent data show that nM to microM levels of these lipophilic molecules are potent regulators of cell functions in vitro. Although long-chain fatty acyl-CoA are present at several hundred ...

journal_title：Lipids

authors： Gossett RE,Frolov AA,Roths JB,Behnke WD,Kier AB,Schroeder F

更新日期：1996-09-01 00:00:00

abstract：:The present study aimed to elucidate the effective phylogenetic specificity of distribution of a cis-4,7,10, trans-13-22:4 (22:4(n-9)Delta13trans) among pectinids. For this purpose, we extended the analysis of membrane glycerophospholipids FA composition to 13 species of scallops, covering 11 genera and 7 tribes repre...

journal_title：Lipids

authors： Kraffe E,Grall J,Palacios E,Guerra C,Soudant P,Marty Y

更新日期：2010-05-01 00:00:00

abstract：:Bile acids solubilize proteins from liver plasma membrane both in vivo and in vitro. The ability to solubilize the proteins is dependent on the species of bile acid. In this paper, the effect of phospholipid on the solubilization of a membrane-bound enzyme by bile acids was investigated in vitro. Taurocholate (TC) and...

journal_title：Lipids

authors： Nokubo M

更新日期：1987-01-01 00:00:00

abstract：:The current study evaluated the composition and relationships of polyunsaturated fatty acid biohydrogenation products (PUFA-BHP) from the perirenal (PRF) and subcutaneous fat (SCF) of yearling steers fed a 70 % grass hay diet with concentrates containing either sunflower-seed (SS) or flaxseed (FS). Analysis of varianc...

journal_title：Lipids

authors： Mapiye C,Aalhus JL,Turner TD,Rolland DC,Basarab JA,Baron VS,McAllister TA,Block HC,Proctor SD,Dugan ME

更新日期：2014-03-01 00:00:00

abstract：:Membrane phospholipid (PL) composition has been shown to affect cellular function by altering membrane physical structure. The sarcolemma plasma membrane (SLpm) is integral to skeletal muscle function and health. Previous studies assessing SLpm PL composition have demonstrated contamination from transverse (t)-tubule,...

journal_title：Lipids

authors： Fajardo VA,McMeekin L,Basic A,Lamb GD,Murphy RM,LeBlanc PJ

更新日期：2013-04-01 00:00:00

abstract：:A ubiquitously expressed member of the cytochrome P450 superfamily, CYP51, encodes lanosterol 14alpha-demethylase, the first step in the conversion of lanosterol into cholesterol in mammals. The biosynthetic intermediates of lanosterol 14alpha-demethylation are oxysterols, which inhibit HMG-CoA reductase and sterol sy...

journal_title：Lipids

authors： Gibbons GF

更新日期：2002-12-01 00:00:00

abstract：:After two months feeding either an (n-3) or an (n-6) fatty acid-rich diet, two groups of trout were switched to the (n-6) or the (n-3) fatty acid-rich diet, respectively. Half of each group was treated with 0.03% 5,8,11,14-eicosatetraynoic acid (ETYA) in the diet. Liver and intestinal brush border membrane lipids were...

journal_title：Lipids

authors： Pelletier X,Leray C

更新日期：1987-12-01 00:00:00

abstract：:The pyrrolidide and picolinyl ester derivatives of the fatty acids in two natural lipid samples rich in unsaturated fatty acids, pig testis lipids and cod liver oil were satisfactorily resolved on capillary columns of fused silica coated with stationary phases of varying polarity. The picolinyl esters, in particular, ...

journal_title：Lipids

authors： Christie WW,Brechany EY,Johnson SB,Holman RT

更新日期：1986-10-01 00:00:00

abstract：:In this study, to obtain further information on the structural diversity of non-methylene-interrupted (NMI) fatty acids (FA) in the gonads of the limpet Cellana toreuma, previously unreported minor NMI FA, fractionated by argentation thin-layer chromatography (TLC), in the ovaries were characterized by gas chromatogra...

journal_title：Lipids

authors： Kawashima H

更新日期：2020-05-01 00:00:00

abstract：:Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but al...

journal_title：Lipids

authors： Reddy BS

更新日期：1992-10-01 00:00:00

abstract：:Competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase improve hypercholesterolemia. However, reports about the effects of these agents on bile acid synthesis, the metabolic pathway of cholesterol, are conflicting. We studied the short-term effect on one of these agents, pravastatin, on bile acid synthesis...

journal_title：Lipids

authors： Yoshida T,Honda A,Shoda J,Abei M,Matsuzaki Y,Tanaka N,Miyazaki H,Osuga T

更新日期：1997-08-01 00:00:00

abstract：:Several experimental approaches were used to determine whether rat liver and testes express an acyl-CoA-dependent delta8 desaturase. When [1-14C]5,11,14-eicosatrienoic acid was injected via the tail vein, or directly into testes, it was incorporated into liver and testes phospholipids, but it was not metabolized to ot...

journal_title：Lipids

authors： Chen Q,Yin FQ,Sprecher H

更新日期：2000-08-01 00:00:00

abstract：:The effect of Rauscher Leukemia Virus (MuLV-R) infection on the lipid composition of mouse spleen from BALB/c mice was investigated. Drastic changes in the lipid composition of the spleen as a result of tumor growth induced by the virus could be demonstrated at 21 days after infection. The molar ratio of cholesterol t...

journal_title：Lipids

authors： Montfoort A,Boere WA,Griensven LJLDV

更新日期：1976-11-01 00:00:00

abstract：:This study investigates the protective effect of N-stearoylethanolamine (NSE), a bioactive N-acylethanolamine , on the lipid profile distribution in the pancreas of obesity-induced insulin resistant (IR) rats fed with prolonged high fat diet (58% of fat for 6 months). The phospholipid composition was determined using ...

journal_title：Lipids

authors： Onopchenko OV,Kosiakova GV,Oz M,Klimashevsky VM,Gula NM

更新日期：2015-01-01 00:00:00

abstract：:The hypolipidemic drug clofibrate is known to affect the hepatic transport of various organic anions including bilirubin, fatty acids and sulfobromophthalein. Changes in the rate of metabolism and/or intracellular transport have been claimed responsible for the effect. To evaluate these possibilities, the transport of...

journal_title：Lipids

authors： Sorrentino D,Weisiger RA,Bass NM,Licko V

更新日期：1989-05-01 00:00:00

abstract：:This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...

journal_title：Lipids

authors： Jenko KJ,Vanderhoek JY

更新日期：2008-04-01 00:00:00

abstract：:The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-alpha-tocopheryl acetate for 6 wk. Tocopherol levels in the diets, plasma, liver, kidn...

journal_title：Lipids

authors： Meydani SN,Shapiro AC,Meydani M,Macauley JB,Blumberg JB

更新日期：1987-05-01 00:00:00

abstract：:Plant diseases caused by Phytophthora species are serious threats to agriculture and the natural environment. Genome sequencing has revealed the lack of a gene for canonical phospholipase C (PLC), an enzyme that was hitherto thought to be ubiquitous in eukaryotes. PLC acts in the hydrolysis of phosphatidylinositol 4,5...

journal_title：Lipids

authors： Howard JM,Beech PL,Callahan DL

更新日期：2018-08-01 00:00:00

abstract：:A one-carbon degradation of long-chain fatty acids, which was found to occur in the brains of rats in vivo, has been investigated in a brain microsomal fraction in vitro. Decarboxylation of the alpha-hydroxy acid, a possible intermediate product between the substrate and the next shorter acid, in the presence of brain...

journal_title：Lipids

authors： Macdonald RC,Mead JF

更新日期：1968-05-01 00:00:00

abstract：:This study was designed to examine the incorporation of omega-3 (n-3) fatty acids into the immune tissues of pigs nursing fish oil-fed sows and to determine the effect of maternal dietary n-3 consumption on in vitro immune cell eicosanoid production. On day 107 of gestation, 12 sows were randomly allotted to a diet co...

journal_title：Lipids

authors： Fritsche KL,Alexander DW,Cassity NA,Huang SC

更新日期：1993-08-01 00:00:00

abstract：:Lipids were extracted from four dog adipose tissue sites, perirenal, pericardial, inguinal subcutaneous, and mesenteric. The triglycerides were purified by thin-layer chromatography and the sub-classes separated by silver nitrate-silica gel plates. Gas chromatography was used to delineate the fatty acid composition of...

journal_title：Lipids

authors： Gold M

更新日期：1968-11-01 00:00:00

abstract：:Milk fatty acids consist of about 20-25% palmitic acid (16:0), with about 70% of 16:0 esterified to the sn-2 position of the milk triacylglycerols. Hydrolysis of dietary triacylglycerols by endogeneous lipases produces sn-2 monoacylglycerols and free fatty acids, which are absorbed, reesterified, and then secreted int...

journal_title：Lipids

authors： Innis SM,Dyer R,Nelson CM

更新日期：1994-08-01 00:00:00

abstract：:Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...

journal_title：Lipids

authors： Suzuki M,Muranaka T

更新日期：2007-02-01 00:00:00

abstract：:The combustion method has been modified to increase the recovery of tritiated water after combustion of a tritium-labeled tissue sample. This was accomplished by cooling the bottom of the combustion flask in a dry ice-acetone bath while irradiating the top with an infrared lamp. The procedure resulted in at least 92% ...

journal_title：Lipids

authors： Parekh CK,Eigen E

更新日期：1968-05-01 00:00:00

abstract：:A 24-hr pretreatment of cultured human fibroblasts with trifluoperazine induced a marked increase in incorporation of saturated (stearic, palmitic) and unsaturated (oleic, arachidonic) fatty acids into phospholipids (1.5- to 2-fold for 5.10(-5) M trifluoperazine). Concomitantly, incorporation into cholesteryl esters w...

journal_title：Lipids

authors： Mazière C,Mazière JC,Mora L,Auclair M,Polonovski J

更新日期：1988-05-01 00:00:00

abstract：:Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and ...

journal_title：Lipids

authors： Luo T,Deng ZY,Li XP,Rao H,Fan YW

更新日期：2014-05-01 00:00:00

abstract：:In tests with purified menhaden oil at 37C and with squalene at 37C and 50C, unsubstituted tocol, 7,8-dimethyl tocol (gamma-tocol), and 8-methyl tocol (sigma-tocol) were superior antioxidants to 5,7-dimethyl tocol and 5,7,8-trimethyl tocol (alpha-tocol). In contrast to previous reports, there were no differences in th...

journal_title：Lipids

authors： Olcott HS,Van der Veen J

更新日期：1968-07-01 00:00:00

abstract：:Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...

journal_title：Lipids

authors： Alonso A,Martínez-González MA

更新日期：2004-12-01 00:00:00

abstract：:High-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) approaches have enabled high selectivity and sensitivity for the identification and quantification of glucosylceramide molecular species. Here we demonstrate that HPLC-ESI-MS/MS is an efficient method for character...

journal_title：Lipids

authors： Imai H,Hattori H,Watanabe M

更新日期：2012-12-01 00:00:00