An improved method for analysis of glucosylceramide species having cis-8 and trans-8 isomers of sphingoid bases by LC-MS/MS.

abstract：:The effect of 4,4'-diethylamino-ethoxyhexestrol (DH) on acid esterase in rat liver was studied in vivo and in vitro. The acid esterase activity in the livers of rats treated with 0.125% DH for 1 week was found to decrease more than 60% as compared with that in untreated rats. The addition of DH to the incubation mediu...

journal_title：Lipids

authors： Kasama K,Yoshida K,Takeda S,Tsujimura R,Hasegawa S

更新日期：1976-10-01 00:00:00

abstract：:The anesthetic potency of four derivatives of n-octane was measured by tadpole righting reflex and expressed as effective millimolar concentration of drug in membrane, EDM50. Potency diminished (ED50 increased) in this order: 1-octanol, EDM50 = 5.5; 1-(2-methoxyethoxy)octane, EDM50 = 28; 1-methoxyoctane, EDM50 = 61; a...

journal_title：Lipids

authors： Brockerhoff H,Brockerhoff S,Box LL

更新日期：1986-06-01 00:00:00

abstract：:Unsaturated free fatty acids (FFA) are able to prevent deleterious effects of saturated FFA in skeletal muscle cells although the mechanisms involved are still not completely understood. FFA act as endogenous ligands of peroxisome proliferator-activated receptors (PPAR), transcription factors regulating the expression...

journal_title：Lipids

authors： Tumova J,Malisova L,Andel M,Trnka J

更新日期：2015-10-01 00:00:00

abstract：:Saturated fatty acids are the most abundant fatty acids in the brain, however, there has been some debate regarding the ability of intact dietary saturated fatty acids to be incorporated into the brain. In the present study, we use compound specific isotope analysis to measure the natural abundance carbon isotopic sig...

journal_title：Lipids

authors： Lacombe RJS,Giuliano V,Chouinard-Watkins R,Bazinet RP

更新日期：2018-05-01 00:00:00

abstract：:Dyslipoproteinemia of the Nagase analbuminemic rat (NAR) is characterized by elevated concentrations of VLDL and LDL attributed to increased rates of liver lipoprotein synthesis. Increased lysophosphatidylcholine (LPC) in NAR HDL has been attributed to high plasma LCAT activity. We show here that, as compared with Spr...

journal_title：Lipids

authors： Catanozi S,Rocha JC,Passarelli M,Mesquita CH,Suguiama VY,Guzzo ML,dos Santos Filho A,Quintão EC,Nakandakare ER

更新日期：2006-07-01 00:00:00

abstract：:Factors involved in reduced glutathione (GSH) and vitamin E-mediated inhibition of NADPH-dependent rat liver microsomal lipid peroxidation were examined. Lipid peroxidation was monitored over a time-course of 180 min by thiobarbituric acid reactive product formation. The addition of 5 mM GSH to the reaction system con...

journal_title：Lipids

authors： Graham KS,Reddy CC,Scholz RW

更新日期：1989-11-01 00:00:00

abstract：:Dietary fat intake influences plasma glucose concentration through modifying glucose uptake and utilization by adipose and skeletal muscle tissues. In this paper, we studied the effects of a low-fat diet on diaphragm GLUT4 expression and fatty acid composition in control and streptozotocin-induced diabetic rats. Contr...

journal_title：Lipids

authors： Girón MD,Salto R,Hortelano P,Periago JL,Vargas AM,Suárez MD

更新日期：1999-08-01 00:00:00

abstract：:Oxidative stress is thought to play an important role in atherogenesis. The statin group of cholesterol-lowering drugs have been shown to reduce cardiovascular events and possess antioxidant properties. We aimed to assess the effects of simvastatin on a novel measure of prooxidant-antioxidant balance (PAB) in dyslipid...

journal_title：Lipids

authors： Parizadeh SM,Azarpazhooh MR,Moohebati M,Nematy M,Ghayour-Mobarhan M,Tavallaie S,Rahsepar AA,Amini M,Sahebkar A,Mohammadi M,Ferns GA

更新日期：2011-04-01 00:00:00

abstract：:Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...

journal_title：Lipids

authors： Li R,Yu K,Hildebrand DF

更新日期：2010-02-01 00:00:00

abstract：:Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCA...

journal_title：Lipids

authors： Bell FP,Hubert EV

更新日期：1980-10-01 00:00:00

abstract：:The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...

journal_title：Lipids

authors： Xu X,Wang Y,Constantinou AI,Stacewicz-Sapuntzakis M,Bowen PE,van Breemen RB

更新日期：1999-10-01 00:00:00

abstract：:Using an experimental model that enables the effects of alcohol to be distinguished from the effects of the nonalcoholic components present in wine, we determined whether wine has effects other than those of alcohol on the metabolism of cholesterol. Male rats were fed a standard diet and had free access to water and e...

journal_title：Lipids

authors： Cascón E,Roig R,Ardèvol A,Salvadó MJ,Arola L,Bladé C

更新日期：2001-04-01 00:00:00

abstract：:Membrane phospholipid (PL) composition has been shown to affect cellular function by altering membrane physical structure. The sarcolemma plasma membrane (SLpm) is integral to skeletal muscle function and health. Previous studies assessing SLpm PL composition have demonstrated contamination from transverse (t)-tubule,...

journal_title：Lipids

authors： Fajardo VA,McMeekin L,Basic A,Lamb GD,Murphy RM,LeBlanc PJ

更新日期：2013-04-01 00:00:00

abstract：:Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...

journal_title：Lipids

authors： Yamashita K,Iizuka Y,Imai T,Namiki M

更新日期：1995-11-01 00:00:00

abstract：:Bioassay-guided fractionation of a collection of Moorea bouillonii from Papua New Guinea led to the isolation of a new alkyl amide, mooreamide A (1), along with the cytotoxic apratoxins A-C and E. The planar structure of 1 was elucidated by NMR spectroscopy and mass spectrometry analysis. Structural homology between m...

journal_title：Lipids

authors： Mevers E,Matainaho T,Allara' M,Di Marzo V,Gerwick WH

更新日期：2014-11-01 00:00:00

abstract：:In order to determine the minimal amount of dietary 9-trans, 12-trans-linoleate which can decrease endoperoxide metabolites synthesized and their precursor in rat platelets, graded amounts (0, 0.1, 0.5, 1.0, 2.5%) of the trans-linoleate were fed to rats with a constant amount of all-cis-linoleate (2.5%) for 12 weeks. ...

journal_title：Lipids

authors： Hwang DH,Chanmugam P,Anding R

更新日期：1982-04-01 00:00:00

abstract：:Several water soluble and organic solvent soluble fluorescent peaks were observed in extracts of uteri from vitamin E deficient or supplemented rats following Sephadex column chromatography and spectrophotofluorometric analysis. Levels of one of the organic and two of the water soluble fluorescent peaks were found to ...

journal_title：Lipids

authors： Csallany AS,Ayaz KL,Menken BZ

更新日期：1984-12-01 00:00:00

abstract：:Stimulation of platelets induces a rapid release of arachidonate from specific phospholipids and subsequent remodeling of arachidonate-containing phospholipids. This process is accompanied by transformation of released arachidonate by cyclooxygenase and lipoxygenase enzymes. We addressed the question of whether the cy...

journal_title：Lipids

authors： Chevy F,Wolf C,Colard O

更新日期：1991-12-01 00:00:00

abstract：:Camelina sativa is an oilseed plant rich in n-3 and n-6 fatty acids and extruding the seeds results in high protein meal (*40%) containing high levels of n-3 fatty acids. In this study, we examined the effects of feeding extruded defatted camelina meal to commercial laying hens, measuring egg production, quality, and ...

journal_title：Lipids

authors： Kakani R,Fowler J,Haq AU,Murphy EJ,Rosenberger TA,Berhow M,Bailey CA

更新日期：2012-05-01 00:00:00

abstract：:CLA mixtures are now commercially available. They differ from each other with respect to their content of CLA isomers and their degree of purification. As a group of natural FA, CLA have been widely assumed to be safe. However, the suspected presence of both impurities and particular isomers might induce undesirable s...

journal_title：Lipids

authors： Gaullier JM,Berven G,Blankson H,Gudmundsen O

更新日期：2002-11-01 00:00:00

abstract：:The acylation of lysophospholipids by rat liver acyltransferases was studied. A comparison between ester and ether lysophospholipids as substrates revealed large differences in substrate properties. For instance, oleic acid from oleoyl-CoA and arachidonic acid from arachidonoyl-CoA were not incorporated into 1-O-octad...

journal_title：Lipids

authors： Neumüller W,Fleer EA,Unger C,Eibl H

更新日期：1987-11-01 00:00:00

abstract：:The biosynthesis of [14C] CDP-diglyceride was studied using rat liver microsomes which were endogenously labeled with [14C] phosphatidic acid by preincubation of unlabeled microsomes with sn-[14C] glycerol-3-phosphate and appropriate cofactors. The formation of CDP-diglyceride from radioactive phosphatidate showed an ...

journal_title：Lipids

authors： Holub BJ,Piekarski J

更新日期：1976-04-01 00:00:00

abstract：:The production of cardiac arrhythmias and the elevation of lysophosphatidylcholine level in the ischemic myocardium have been well-documented in a number of studies. However, the relationship between the production arrhythmias and the elevation of tissue lysophosphatidylcholine level was not reported. In this study, t...

journal_title：Lipids

authors： Kinnaird AA,Choy PC,Man RY

更新日期：1988-01-01 00:00:00

abstract：:The objective of the present studies was to examine the effect of dietary fat on the lipid composition of rat colonocytes and their utilization of short-chain fatty acids (SCFA). Rats were fed 14% beef fat, fish oil or safflower oil plus 2% corn oil in a semi-synthetic base diet for 4 wk. Colonocytes were isolated and...

journal_title：Lipids

authors： Awad AB,Ferger SL,Fink CS

更新日期：1990-06-01 00:00:00

abstract：:During ruminal biohydrogenation of α-linolenic acid, a non-conjugated non-methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15-18:2. The present study was designed to examine whether t10,c15-18:2 would exert similar anti-adipogenic effects compared to t10,c12-18:2 in 3T3-L1 adipocy...

journal_title：Lipids

authors： Vahmani P,Meadus WJ,Rolland DC,Duff P,Dugan ME

更新日期：2016-11-01 00:00:00

abstract：:Choline is an essential nutrient required for the biosynthesis of membrane lipid phosphatidylcholine (PtdCho). Here we elucidate the mechanism of how palmitic acid (PAM) and oleic acid (OLA) regulate choline transporter-like protein 1 (CTL1/SLC44A1) function. We evaluated the mechanism of extracellular and intracellul...

journal_title：Lipids

authors： Schenkel LC,Bakovic M

更新日期：2014-08-01 00:00:00

abstract：:A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of th...

journal_title：Lipids

authors： Lin YH,Hanson JA,Strandjord SE,Salem NM,Dretsch MN,Haub MD,Hibbeln JR

更新日期：2014-08-01 00:00:00

abstract：:By using reverse transcription-polymerase chain reaction technology (RT-PCR) and Northern blot analysis, the tissue-specific mRNA expression patterns of seven mouse lipoxygenases (LOX)--including 5S-, 8S-, three isoforms of 12S-, 12R-LOX, and a LOX of an as-of-yet unknown specificity, epidermis-type LOX-3 (e-LOX-3)--w...

journal_title：Lipids

authors： Heidt M,Fürstenberger G,Vogel S,Marks F,Krieg P

更新日期：2000-07-01 00:00:00

abstract：:Rats were fed either a high alpha-linolenate diet or a high linoleate diet from weaning to 4 mon of age. Soybean oil was used as a control. Phospholipid compositions of erythrocytes from the three dietary groups were not significantly different. However, the difference in the alpha-linolenate (18:3n-3)/linoleate (18:2...

journal_title：Lipids

authors： Sakai K,Okuyama H,Kon K,Maeda N,Sekiya M,Shiga T,Reitz RC

更新日期：1990-12-01 00:00:00

abstract：:A 24-hr pretreatment of cultured human fibroblasts with trifluoperazine induced a marked increase in incorporation of saturated (stearic, palmitic) and unsaturated (oleic, arachidonic) fatty acids into phospholipids (1.5- to 2-fold for 5.10(-5) M trifluoperazine). Concomitantly, incorporation into cholesteryl esters w...

journal_title：Lipids

authors： Mazière C,Mazière JC,Mora L,Auclair M,Polonovski J

更新日期：1988-05-01 00:00:00