Abstract:
:Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCAT when studied over the concentration range of 1 to 5 mM. The order of inhibition was dibucaine>benzocaine>tetracaine>lidocaine>procaine. Since LCAT activity represents the combined effect of a deacylation step and an esterification step, inhibition of LCAT by local anesthetics could theoretically involve either or both steps.
journal_name
Lipidsjournal_title
Lipidsauthors
Bell FP,Hubert EVdoi
10.1007/BF02534370subject
Has Abstractpub_date
1980-10-01 00:00:00pages
811-4issue
10eissn
0024-4201issn
1558-9307journal_volume
15pub_type
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