Abstract:
:Linoleic acid was efficiently converted into the two major components of conjugated linoleic acid, 9Z,11E-octadecadienoic (1a) and 10E,12Z-octadecadienoic acid (1b) using either the superbase (n-butyllithium/potassium tert-butoxide) or by simply refluxing with KOH in 1-butanol. In turn, 1a and 1b were separated from each other using the lipase from Aspergillus niger via stereoselective esterification in 1-butanol. This enzyme has a preference for the 9Z,11E isomer, 1a, and has excellent selectivity. This method has allowed the ready preparation of gram quantities of 1a and 1b in their highly purified forms, which are not readily accessible by current methods.
journal_name
Lipidsjournal_title
Lipidsauthors
Chen CA,Lu W,Sih CJdoi
10.1007/s11745-999-0436-ysubject
Has Abstractpub_date
1999-08-01 00:00:00pages
879-84issue
8eissn
0024-4201issn
1558-9307journal_volume
34pub_type
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