Abstract:
:Azaserine induced two phenotypically different populations of foci, namely, acidophilic and basophilic foci. The effects of dietary modification during the post-initiation phase of carcinogenesis were examined. A diet of 20% (w/w) unsaturated fat (unsat) compared to a 20% saturated fat (sat) diet or a control diet (5% unsaturated fat) increased the number of acidophilic foci, as well as the thymidine labeling index (LI) of their nuclei. While the basophilic foci are carcinogen-induced and at 2.5 mo post-initiation have a similarly high growth rate to the acidophilic foci, this rate is not sustained as indicated by examination of both the LI and mean size of foci at 4 mo post-initiation.
journal_name
Lipidsjournal_title
Lipidsauthors
Roebuck BDdoi
10.1007/BF02536413subject
Has Abstractpub_date
1986-04-01 00:00:00pages
281-4issue
4eissn
0024-4201issn
1558-9307journal_volume
21pub_type
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