Abstract:
:This work reports the effect of the apolipoproteins A-I and A-II (apoA-I and apoA-II) on the release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist (IL-1Ra) and on the oxidative burst of human neutrophils. By themselves, apoA-I and apoA-II do not affect the basal liberation of these cytokines, whereas apoA-I affects the release of IL-1beta from lipopolysaccharide (LPS)-stimulated neutrophils and apoA-II affects IL-8 released from LPS-stimulated neutrophils. ApoA-II also decreases the production of IL-8 released by neutrophils stimulated with the acute phase apolipoprotein serum amyloid A. Both apoA-I and apoA-II exerted approximately 30% inhibition on the oxidative burst of neutrophils stimulated by opsonized zymosan, as revealed by the luminol-enhanced chemiluminescence assay. These findings give additional support to the idea that the role of human plasma lipoproteins and apolipoproteins goes beyond their function in lipid transport and metabolism. HDL apolipoproteins appear to be a class of mediators that can participate in the regulation of the activity of neutrophils.
journal_name
Lipidsjournal_title
Lipidsauthors
Furlaneto CJ,Ribeiro FP,Hatanaka E,Souza GM,Cassatella MA,Campa Adoi
10.1007/s11745-002-0981-4subject
Has Abstractpub_date
2002-09-01 00:00:00pages
925-8issue
9eissn
0024-4201issn
1558-9307journal_volume
37pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Apolipoprotein E (apo E) plays an essential role in lipoprotein metabolism, where it is involved in the clearance of chylomicrons and very low density lipoproteins. Apart from some rare variants, apo E exists in three common isoforms (E2, E3, and E4). The different isoforms have not only been associated with different...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0500-7
更新日期:2000-01-01 00:00:00
abstract::Recently, significant differences between rats fed a casein diet and rats fed a soybean protein diet have been observed in hepatic phospholipid fatty acid patterns (Sjöblom, L., and Eklund, A., Biochim. Biophys. Acta 1004, 187-192, 1990). The influence of these two diets on the delta 6 desaturase activity was investig...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544003
更新日期:1991-02-01 00:00:00
abstract::Docosahexaenoic acid (DHA), a prominent long-chain fatty acid of the omega-3 family, is present at high amount in brain tissues, especially in membrane phospholipids. This polyunsaturated fatty acid is the precursor of various oxygenated lipid mediators involved in diverse physiological and pathophysiological processe...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12006
更新日期:2018-01-01 00:00:00
abstract::Decreased triacylglycerol synthesis within hepatocytes due to decreased diacylglycerol acyltransferase (DGAT) activity has been suggested to be an important mechanism by which diets rich in fish oil lower plasma triacylglycerol levels. New findings suggest that eicosapentaenoic acid (EPA), and not docosahexaenoic acid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0445-x
更新日期:1999-09-01 00:00:00
abstract::This paper describes a simple method for the analysis of tocopherols in tissues by which frozen tissues-70 degrees C were pulverized at dry ice temperatures (-70 degrees C) and immediately extracted with hexane. There was no need to remove the coeluting lipids from tissues by saponification, since at that level of neu...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0040-1
更新日期:1997-03-01 00:00:00
abstract::The purpose of the present study was to investigate the physiological control of the main regulatory enzymes of cholesterol metabolism in isolated enterocytes obtained from chick duodenum, jejunum and ileum. Cholesterol feeding resulted in an inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and mevalonate 5-pyr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536087
更新日期:1993-06-01 00:00:00
abstract::The growth inhibitory effects of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) and various liposome compositions of ET-18-OCH3 were compared in a standardized growth inhibition assay utilizing a diverse tumor cell line panel including cell lines expressing multidrug resistance. ET-18-OCH3 and ELL-1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0135-8
更新日期:1997-10-01 00:00:00
abstract::The major component of cutin from the fruit of both tomato and papaya, dihydroxypalmitate, is shown to have plain positive rotation and is, therefore, assigned L configuration in analogy to other known hydroxy fatty acids. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533487
更新日期:1978-11-01 00:00:00
abstract::The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9,trans-11 CLA (9c,11 tCLA); trans-10,cis-12 CLA (10t,12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic hamsters. One hundred ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5068-8
更新日期:2006-01-01 00:00:00
abstract::This study was conducted to investigate the effects of dietary cyclic fatty acid monomers (CFAM), contained in heated fat from a commercial deep-fat frying operation, on rat liver enzyme activity. A partially hydrogenated soybean oil (PHSBO) used 7 d (7-DH) for frying foodstuffs, or 0.15% methylated CFAM diets was fed...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0256-0
更新日期:1998-07-01 00:00:00
abstract::The effect of essential fatty acid (EFA) deficiency on rat-brain myelin proteins was studied. Rats were maintained on a lipid-free diet and compared with control rats fed the same diet supplemented with 3% corn oil. At 17 days of age, each pup was injected with [3H]leucine and rats from each group were killed over a p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537414
更新日期:1984-06-01 00:00:00
abstract::This study was designed to examine the incorporation of omega-3 (n-3) fatty acids into the immune tissues of pigs nursing fish oil-fed sows and to determine the effect of maternal dietary n-3 consumption on in vitro immune cell eicosanoid production. On day 107 of gestation, 12 sows were randomly allotted to a diet co...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535986
更新日期:1993-08-01 00:00:00
abstract::An important enzyme involved in phospholipid turnover is the acyl-CoA: lysophosphatidylcholine acyltransferase (LPCAT). Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3233-y
更新日期:2008-10-01 00:00:00
abstract::The tail gland of the red fox (Vulpes vulpes) secretes lipids containing volatile terpenes used in social communication. We have analysed lipids extracted from fur of the tail gland, body (flanks) and muzzle of foxes. GC-MS showed a novel group of iso-valerate and tiglate monoesters of alkane-1,2-diols (C18:0-22:0). T...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4270-1
更新日期:2017-07-01 00:00:00
abstract::A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3918-3
更新日期:2014-08-01 00:00:00
abstract::Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536287
更新日期:1995-11-01 00:00:00
abstract::The effect of 1.7-2.2 mg/day oral phenobarbital over short (1 MO) and long term (6-24 MO) treatment on primary bile acid (BA) secretion, composition, synthesis, pool size, and enterohepatic cycling rates as well as phospholipid (PL) and cholesterol (C) secretion rates and biliary composition was determined in 12 asymp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533915
更新日期:1979-03-01 00:00:00
abstract::A maternal high fat diet (HFD) can have adverse effects on skeletal muscle development. Skeletal muscle PLIN proteins (PLIN2, 3 and 5) are thought to play critical roles in lipid metabolism, however effects of HFD on PLIN and lipases (HSL, ATGL, CGI-58) in mothers as well as their offspring have yet to be investigated...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3985-5
更新日期:2015-02-01 00:00:00
abstract::The phospholipid composition of gill tissue from thermally acclimated rainbow trout, Salmo gairdneri, was determined by Iatroscan analysis following an initial development of the chromarods in a non-polar solvent to remove neutral lipids. Standard curves for all phospholipids, although linear through most of the conce...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534892
更新日期:1985-08-01 00:00:00
abstract::Microtiter plate methods were developed for the enzymatic determination of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG), and for the turbidometric determination of apolipoproteins. The micromethods resulted in accurate, precise values that were in good agreement with...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535780
更新日期:1993-02-01 00:00:00
abstract::The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0454-9
更新日期:1999-10-01 00:00:00
abstract::Barth syndrome (BTHS) is an X-linked genetic disease resulting in loss of cardiolipin (Ptd2Gro). Patients may be predisposed to hypoglycemia and exhibit increases in whole-body glucose disposal rates and a higher fat mass percentage. We examined the reasons for this in BTHS lymphoblasts. BTHS lymphoblasts exhibited a ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4232-7
更新日期:2017-02-01 00:00:00
abstract::Treatment of (13S,9Z,11E)-13-hydroperoxy-9,11-octadecadienoic acid (13S-HPODE) with strong alkali resulted in the formation of about 75% of the corresponding hydroxy acid, (13S,9Z,11E)-13-hydroxy-9,11-octadecadienoic acid (13S-HODE), and the remaining 25% of products was a mixture of several oxidized fatty acids, the ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522458
更新日期:1996-10-01 00:00:00
abstract::The biosynthesis of [14C] CDP-diglyceride was studied using rat liver microsomes which were endogenously labeled with [14C] phosphatidic acid by preincubation of unlabeled microsomes with sn-[14C] glycerol-3-phosphate and appropriate cofactors. The formation of CDP-diglyceride from radioactive phosphatidate showed an ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544050
更新日期:1976-04-01 00:00:00
abstract::Lipoproteins from the plasma of three nonlactating Holstein cows were isolated using either preparative ultracentrifugation or gel filtration chromatography. Lipoprotein classes obtained by ultracentrifugation were very low density plus chylomicra, less than 1.006 g/ml; low density, 1.007-1.039 g/ml; high density1, 1....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534638
更新日期:1983-11-01 00:00:00
abstract::The effects of n-3 fatty acids on plasma lipids, lipoproteins and apoproteins have usually been studied in humans after feeding of purified fish oil. This study describes the effect of a natural diet, containing salmon as the source of n-3 fatty acids, on these parameters as compared to a diet very low in n-3 fatty ac...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544001
更新日期:1991-02-01 00:00:00
abstract::The 4-monomethylsterol and 4,4-dimethylsterol fractions were separated from the unsaponifiables of 20 vegetable oils by preparative thin layer chromatography, and their compositions were determined by gas liquid chromatography. Tentative identification of the individual components of these fractions was carried out by...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532729
更新日期:1975-10-01 00:00:00
abstract::Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-010-3385-4
更新日期:2010-02-01 00:00:00
abstract::The pyrrolidide and picolinyl ester derivatives of the fatty acids in two natural lipid samples rich in unsaturated fatty acids, pig testis lipids and cod liver oil were satisfactorily resolved on capillary columns of fused silica coated with stationary phases of varying polarity. The picolinyl esters, in particular, ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537217
更新日期:1986-10-01 00:00:00
abstract::Although hypocholesterolemia is a reported finding in sickle cell disease (SCD), low-density lipoprotein (LDL)/high-density lipoprotein (HDL) subfractions and HDL-associated enzymes have not been determined in SCD patients. Blood was collected from 38 hemoglobin (Hb)A volunteers and 45 homozygous HbSS patients who had...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3849-4
更新日期:2013-12-01 00:00:00