A maternal high fat diet has long-lasting effects on skeletal muscle lipid and PLIN protein content in rat offspring at young adulthood.

Abstract:

:A maternal high fat diet (HFD) can have adverse effects on skeletal muscle development. Skeletal muscle PLIN proteins (PLIN2, 3 and 5) are thought to play critical roles in lipid metabolism, however effects of HFD on PLIN and lipases (HSL, ATGL, CGI-58) in mothers as well as their offspring have yet to be investigated. The primary objective of this study was to determine whether maternal HFD would influence skeletal muscle lipase and PLIN protein content in offspring at weaning (19 d) and young adulthood (3 mo). Female rats (28 d old, n = 9/group) were fed control (CON, AIN93G, 7% soybean oil) or HFD (AIN93G, 20% lard) for 10 weeks prior to mating and throughout pregnancy and lactation. All offspring were weaned to CON [n = 18/group, 1 female and 1 male pup per litter were studied at weaning (19 d) and 3 mo of age]. There was no effect of sex for the main outcomes measured in plantaris, therefore male and female data was combined. Maternal HFD resulted in higher triacylglycerol content in pups at 3 mo (p < 0.05), as well as in the dams (p = 0.015). Maternal HFD resulted in higher PLIN5 content in pups at weaning and 3 mo (p = 0.05). PLIN2 and PLIN5 content decreased at 3 mo versus weaning (p < 0.001). HFD dams had a higher PLIN3 content (p = 0.016). Diet had no effect on ATGL, CGI-58, or HSL content. In conclusion, exposure to a maternal HFD resulted in higher skeletal muscle lipid and PLIN5 content in plantaris of offspring through to young adulthood.

journal_name

Lipids

journal_title

Lipids

authors

MacPherson RE,Castelli LM,Miotto PM,Frendo-Cumbo S,Milburn A,Roy BD,LeBlanc PJ,Ward WE,Peters SJ

doi

10.1007/s11745-014-3985-5

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

205-17

issue

2

eissn

0024-4201

issn

1558-9307

journal_volume

50

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Ether lipids and analogs in experimental cancer therapy. A brief review of the Munich experience.

    abstract::This review covers the work of our laboratory on the antineoplastic activity of some ether lipids and derivatives that are related to platelet-activating factor (PAF). Various 1-O-alkyl lysophospholipid derivatives (ALP) show therapeutic activity in mouse transplant tumor models and in metastatic 3-Lewis lung carcinom...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/BF02535567

    authors: Berdel WE

    更新日期:1987-11-01 00:00:00

  • Detection of Endogenous Phosphatidylinositol 4,5-bisphosphate in Phytophthora cinnamomi.

    abstract::Plant diseases caused by Phytophthora species are serious threats to agriculture and the natural environment. Genome sequencing has revealed the lack of a gene for canonical phospholipase C (PLC), an enzyme that was hitherto thought to be ubiquitous in eukaryotes. PLC acts in the hydrolysis of phosphatidylinositol 4,5...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12093

    authors: Howard JM,Beech PL,Callahan DL

    更新日期:2018-08-01 00:00:00

  • Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.

    abstract::Unsaturated free fatty acids (FFA) are able to prevent deleterious effects of saturated FFA in skeletal muscle cells although the mechanisms involved are still not completely understood. FFA act as endogenous ligands of peroxisome proliferator-activated receptors (PPAR), transcription factors regulating the expression...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4058-0

    authors: Tumova J,Malisova L,Andel M,Trnka J

    更新日期:2015-10-01 00:00:00

  • Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes.

    abstract::Mice exposed to cold rely upon brown adipose tissue (BAT)-mediated nonshivering thermogenesis to generate body heat using dietary glucose and lipids from the liver and white adipose tissue. In this report, we investigate how cold exposure affects the PI3 K/Akt signaling cascade and the expression of genes involved in ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3422-3

    authors: Deiuliis JA,Liu LF,Belury MA,Rim JS,Shin S,Lee K

    更新日期:2010-06-01 00:00:00

  • Effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens.

    abstract::The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3104-y

    authors: Tang X,Ma H,Zou S,Chen W

    更新日期:2007-11-01 00:00:00

  • Acetate treatment increases fatty acid content in LPS-stimulated BV2 microglia.

    abstract::Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3911-x

    authors: Bhatt DP,Rosenberger TA

    更新日期:2014-07-01 00:00:00

  • Formation of cleavage products by autoxidation of lycopene.

    abstract::The cleavage products formed by autoxidation of lycopene were evaluated in order to elucidate possible oxidation products of lycopene in biological tissues. Lycopene solubilized at 50 microM in toluene, aqueous Tween 40, or liposomal suspension was oxidized by incubating at 37 degrees C for 72 h. Among a number of oxi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0706-8

    authors: Kim SJ,Nara E,Kobayashi H,Terao J,Nagao A

    更新日期:2001-02-01 00:00:00

  • Diversity of mouse lipoxygenases: identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern.

    abstract::By using reverse transcription-polymerase chain reaction technology (RT-PCR) and Northern blot analysis, the tissue-specific mRNA expression patterns of seven mouse lipoxygenases (LOX)--including 5S-, 8S-, three isoforms of 12S-, 12R-LOX, and a LOX of an as-of-yet unknown specificity, epidermis-type LOX-3 (e-LOX-3)--w...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0576-0

    authors: Heidt M,Fürstenberger G,Vogel S,Marks F,Krieg P

    更新日期:2000-07-01 00:00:00

  • High dietary cholesterol masks type 2 diabetes-induced osteopenia and changes in bone microstructure in rats.

    abstract::Type 2 diabetes mellitus (T2DM) often occurs concurrently with high blood cholesterol or dyslipidemia. Although T2DM has been hypothesized to impair bone microstructure, several investigations showed that, when compared to age-matched healthy individuals, T2DM patients had normal or relatively high bone mineral densit...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3950-3

    authors: Lapmanee S,Charoenphandhu N,Aeimlapa R,Suntornsaratoon P,Wongdee K,Tiyasatkulkovit W,Kengkoom K,Chaimongkolnukul K,Seriwatanachai D,Krishnamra N

    更新日期:2014-10-01 00:00:00

  • Separation and quantitation of mono-, di-, and triglycerides and free oleic acid using thin-layer chromatography with flame-ionization detection.

    abstract::alpha-Monoolein was prepared from glycidol and oleic acid by the regioselective opening of glycidol in the presence of an anionic resin. During the reaction, the lipochemical synthesis medium becomes enriched in monoolein, the effective emulsifying agent. This mixture can be analyzed by thin-layer chromatography coupl...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522406

    authors: Peyrou G,Rakotondrazafy V,Mouloungui Z,Gaset A

    更新日期:1996-01-01 00:00:00

  • Effects of different fractions of the barley kernel on the hepatic lipid metabolism of chickens.

    abstract::Various physical fractions of the barley kernel were fed to one-day-old female and male chickens to determine their effect on hepatic beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase, cholesterol 7 alpha-hydroxylase and the lipogenic enzymes, acetyl-CoA carboxylase (ACX), malic enzyme (ME), citrate-clea...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534592

    authors: Burger WC,Qureshi AA,Prentice N,Elson CE

    更新日期:1982-12-01 00:00:00

  • Intermembrane cholesterol transfer: role of sterol carrier proteins and phosphatidylserine.

    abstract::The effect of phosphatidylserine and sterol carrier proteins on cholesterol exchange was determined using an assay not requiring separation of donor and acceptor membrane vesicles. Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called ste...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544032

    authors: Schroeder F,Butko P,Hapala I,Scallen TJ

    更新日期:1990-11-01 00:00:00

  • Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens.

    abstract::The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols, modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a co...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-5119-1

    authors: Yu SG,Thomas AM,Gapor A,Tan B,Qureshi N,Qureshi AA

    更新日期:2006-05-01 00:00:00

  • The effect of various dietary factors on the size distribution of lymph fat particles in rat.

    abstract::By means of cellulose acetate electrophoresis and measurement of radio-activity, lipoproteins (d less than or equal to 1,006) of lymph collected from rats fed a diet containing fats added to labeled fatty acids for 20-24 hr, have been separated into two kinds differing in their size. Fats with different saturated and ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535449

    authors: Boquillon M,Paris R,Clement J

    更新日期:1977-06-01 00:00:00

  • Elevated production of docosahexaenoic acid in females: potential molecular mechanisms.

    abstract::Observational evidence suggests that in populations consuming low levels of n-3 highly unsaturated fatty acids, women have higher blood levels of docosahexaenoic acid (DHA; 22:3n-6) as compared with men. Increased conversion of alpha-linolenic acid (ALA; 18:3n-3) to DHA by females has been confirmed in fatty acid stab...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-010-3391-6

    authors: Kitson AP,Stroud CK,Stark KD

    更新日期:2010-03-01 00:00:00

  • The structural analysis of wheat flour glycerolipids.

    abstract::The compositions of the fatty acids in the 1, 2 and 3 positions of the principal glycerolipids and their various stereoisomers were determined. Fatty acids in the 1 and 3 positions of triglycerides were similar in composition and less unsaturated than those in the 2 position. Fatty acids in the 1,2-, 1,3- and 2,3-digl...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02531305

    authors: Arunga RO,Morrison WR

    更新日期:1971-10-01 00:00:00

  • Conjugated linoleic acids and CLA-containing phospholipids inhibit NO formation in aortic endothelial cells.

    abstract::This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-008-3160-y

    authors: Jenko KJ,Vanderhoek JY

    更新日期:2008-04-01 00:00:00

  • Human platelets release a paf-acether: acetylhydrolase similar to that in plasma.

    abstract::Intact washed human platelets aggregated in response to paf-acether (paf) and did not metabolize [3H]paf at concentrations up to 10 nM. However, when platelets were lysed by exposure to pH 9.5, resulting in 37.5 +/- 2.5% (mean +/- SD, n = 3) lactic dehydrogenase (LDH) release, 20.5 +/- 5.7% of the radioactivity was de...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536639

    authors: Korth R,Bidault J,Palmantier R,Benveniste J,Ninio E

    更新日期:1993-03-01 00:00:00

  • Effect of dietary linseed oil on tumoricidal activity and eicosanoid production in murine macrophages.

    abstract::Diets that contain high levels of n-3 fatty acids from fish oil have been shown to significantly effect macrophage cytolytic capacity, tumor necrosis factor alpha production and eicosanoid production. The present study was undertaken to determine whether n-3 fatty acids from vegetable origin [linseed oil (LIN)] would ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536100

    authors: Hubbard NE,Chapkin RS,Erickson KL

    更新日期:1994-09-01 00:00:00

  • Preparation and properties of various salt forms of plant phosphatidyl inositols.

    abstract::The Ca and Mg content of flax and corn phosphatidyl inositol fractions has been determined. Procedures were devised to prepare various salt forms of phosphatidyl inositol. The divalent cations were exchanged for monovalent ions (Na or K) on chelating resin columns. With the Folch wash procedure the Na or K forms of ph...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02668119

    authors: Carter HE,Weber EJ

    更新日期:1966-01-01 00:00:00

  • Effect of dietary fats on ovine adipose tissue metabolism.

    abstract::The effects of different dietary fats on ovine adipose tissue metabolism have been investigated. Six-month old sheep were fed for 6 weeks a control diet or diets supplemented with either tallow or a mixture of sunflower seed oil and soybean oil, treated to protect the fats from hydrolysis and hydrogenation in the rume...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532883

    authors: Vernon RG

    更新日期:1976-09-01 00:00:00

  • Influence of trichloroacetic acid-phosphotungstic acid on the thin layer chromatographic mobility of gangliosides.

    abstract::Trichloroacetic acid (TCA)-phosphotungstic acid (PTA) precipitation has been used as a faster procedure than dialysis for the isolation of gangliosides, but the TCA-PTA treatment causes striking abnormalities in the thin layer chromatographic mobilities of the gangliosides. However, a normal chromatographic pattern ca...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533321

    authors: Seyfried TN,Weber EJ,Yu RK

    更新日期:1977-11-01 00:00:00

  • Separation and identification of phospholipid peroxidation products.

    abstract::The molecular species in mixtures of phospholipid hydroperoxides are difficult to separate and identify by typical chromatographic and mass spectrometric techniques. As reported by Havrilla and coworkers, silver ion coordination ion-spray mass spectrometry (CIS-MS) has proven to be a powerful technique for the identif...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0841-2

    authors: Milne GL,Porter NA

    更新日期:2001-11-01 00:00:00

  • A human dietary arachidonic acid supplementation study conducted in a metabolic research unit: rationale and design.

    abstract::While there are many reports of studies that fed arachidonic acid (AA) to animals, there are very few reports of AA feeding to humans under controlled conditions. This 130-d study was conceived as a controlled, symmetrical crossover design with healthy, adult male volunteers. They lived in the metabolic research unit ...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-997-0054-8

    authors: Nelson GJ,Kelley DS,Emken EA,Phinney SD,Kyle D,Ferretti A

    更新日期:1997-04-01 00:00:00

  • Sterol composition of phaeodactylum tricornutum as influenced by growth temperature and light spectral quality.

    abstract::In a detailed sterol analysis of the marine diatom Phaeodactylum tricornutum, free sterols as well as esterified and glycosylated conjugates were found. When the alga was grown under standard conditions (i.e., at 13 degrees C under white light), 64% of total sterols were steryl glycosides. In all sterol classes, excep...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522694

    authors: Véron B,Billard C,Dauguet JC,Hartmann MA

    更新日期:1996-09-01 00:00:00

  • Lipid content of swine influenza and other vaccines.

    abstract::An analysis of the lipids in swine influenza vaccines was performed, comparing six different lots of swine influenza, other influenza and noninfluenza vaccines. Cholesterol content and phospholipid content varied greatly, but there were no major differences between the types of vaccines. Appreciable amounts of phospha...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535698

    authors: Leskawa KC,Hogan EL,Dasgupta S,Chien JL,Erwin RE,Brostoff SW

    更新日期:1986-05-01 00:00:00

  • Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors.

    abstract::Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-010-3524-y

    authors: Gillingham LG,Harris-Janz S,Jones PJ

    更新日期:2011-03-01 00:00:00

  • Effects of dietary vitamin E, selenium, and polyunsaturated fats on in vivo lipid peroxidation in the rat as measured by pentane production.

    abstract::Starting at 21 days of age, groups of six rats each were fed a basal Torula yeast diet supplemented with 0.4% L-methionine and varying amounts of vitamin E as dl-alpha tocopherol acetate, selenium as sodium selenite, and with either 10% stripped corn oil, stripped lard, or coconut oil. By 7 wk, pentane production by r...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533708

    authors: Dillard CJ,Litov RE,Tappel AL

    更新日期:1978-06-01 00:00:00

  • Comparison of separations of fatty acids from fish products using a 30-m Supelcowax-10 and a 100-m SP-2560 column.

    abstract::Commercial fish oils and foods containing fish may contain trans and/or isomerized fatty acids (FA) produced during processing or as part of prepared foods. The current American Oil Chemists' Society (AOCS) official method for marine oils (method Ce 1i-07) is based on separation by use of poly(ethylene glycol) (PEG) c...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-011-3645-y

    authors: Santercole V,Delmonte P,Kramer JK

    更新日期:2012-03-01 00:00:00

  • Lipid composition and peroxide levels of mucosal cells in the rat large intestine in relation to dietary fat.

    abstract::To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in "non-proliferative" and "proliferative" cells in the large intestine, Sprague-Dawley rats were fed diets providing a polyunsaturated-to-saturated fatty acid ratio of 1.2 or 0.3 at a high or low level of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536069

    authors: Turini ME,Thomson AB,Clandinin MT

    更新日期:1991-06-01 00:00:00