Abstract:
:Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critical assessment of the current body of evidence surrounding efficacy of dietary monounsaturated fatty acids (MUFA) for reduction of traditional risk factors defining metabolic syndrome (MetS) and CVD. Due to existing and emerging research on health attributes of MUFA rich diets, and to the low prevalence of chronic disease in populations consuming MUFA rich Mediterranean diets, national dietary guidelines are increasingly recommending dietary MUFA, primarily at the expense of saturated fatty acids (SFA). Consumption of dietary MUFA promotes healthy blood lipid profiles, mediates blood pressure, improves insulin sensitivity and regulates glucose levels. Moreover, provocative newer data suggest a role for preferential oxidation and metabolism of dietary MUFA, influencing body composition and ameliorating the risk of obesity. Mounting epidemiological and human clinical trial data continue to demonstrate the cardioprotective activity of the MUFA content of dietary fat. As the debate on the optimal fatty acid composition of the diet continues, the benefit of increasing MUFA intakes, particularly as a substitute for dietary SFA, deserves considerable attention.
journal_name
Lipidsjournal_title
Lipidsauthors
Gillingham LG,Harris-Janz S,Jones PJdoi
10.1007/s11745-010-3524-ysubject
Has Abstractpub_date
2011-03-01 00:00:00pages
209-28issue
3eissn
0024-4201issn
1558-9307journal_volume
46pub_type
杂志文章,评审相关文献
LIPIDS文献大全abstract::The prevalence of colorectal cancer (CRC) continues to increase. Treatment of CRC remains a significant clinical challenge, and effective therapies for advanced CRC are desperately needed. Increasing attention and ongoing research efforts have focused on krill oil that may provide health benefits to the human body. He...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12281
更新日期:2020-09-15 00:00:00
abstract::A protocol, based on the use of Pseudomonas lipase, is presented to measure quantitatively the amount of triacylglycerols in extracts from cultured cells of tissues. Since the lipase also acts on di- and monoacylglycerols, separation of the extracts by thin-layer chromatography is recommended. In order to allow the li...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-0166-1
更新日期:1997-12-01 00:00:00
abstract::The bile acid pool was found to be ca. 50 mumoles/100 g body wt in male and female rats maintained on standard laboratory chow and ca. 30 mumoles/100 g body wt in those maintained on a standard semisynthetic diet. The distribution of bile acids within the pool was similar in plasma, liver, and intestinal tract, except...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532657
更新日期:1976-02-01 00:00:00
abstract::A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3918-3
更新日期:2014-08-01 00:00:00
abstract::Stearoyl-coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. Recently, SCD1 down-regulation has been implicated in the prevention of obesity, and the improvement of insulin and leptin sensitivity. In this study, we examined...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3784-4
更新日期:2013-05-01 00:00:00
abstract::The effect of dexamethasone on the incorporation and conversion of [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in isolated hepatocytes and in hepatoma tissue culture (HTC) cells was studied. In both kinds of cells, no changes in the exogenous acid incorporation were found when the hormone was added to the ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534824
更新日期:1986-03-01 00:00:00
abstract::Wistar male rats were treated for six days with broad spectrum beta-lactam antibiotics, latamoxef, and cefotaxime. On the seventh day, the number of fecal anaerobic microbes decreased, total fecal bile acids decreased, and bile acid pools increased. Secondary bile acids such as beta-hyocholic, hyodeoxycholic, lithocho...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02523830
更新日期:1996-06-01 00:00:00
abstract::This study proposed lipid fingerprinting of human seminal plasma by mass spectrometry as an analytical method to differentiate biological conditions. For this purpose, we chose infertile men as a model to study specific conditions, namely: high and low seminal plasma lipid peroxidation levels (sub-study 1.1), high and...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3922-7
更新日期:2014-09-01 00:00:00
abstract::Iron and ascorbic acid appear to be the normal catalytic components responsible for the lipid peroxidation reaction in aerobically incubated rat tissue homogenates. The amounts of each present in the catalytically-active fractions of rat liver, brain, testis, and kidney are appropriate to explain the lipid peroxidatio...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533008
更新日期:1966-03-01 00:00:00
abstract::The phospholipid and the fatty chain compositions of diacyl, alkylacyl and alkenylacyl glycerophospholipids of the free-living nematode, Caenorhabditis elegans, were investigated. The phospholipids were comprised of 54.5% ethanolamine glycerophospholipid (EGP), 32.3% choline glycerophospholipid (CGP), 8.1% sphingomyel...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536239
更新日期:1993-09-01 00:00:00
abstract::Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Si...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3302-x
更新日期:2009-06-01 00:00:00
abstract::Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3889-4
更新日期:2014-05-01 00:00:00
abstract::We examined the effect of dietary alpha-linolenic acid (ALA) on the indices of lipid and coagulation status and on the fatty acid composition of serum and peripheral blood mononuclear cell (PBMNC) lipids in ten healthy men (age 21-37 yr) who consumed all their meals at the Western Human Nutrition Research Center for 1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536085
更新日期:1993-06-01 00:00:00
abstract::Cholesterol and cholesteryl esters were separated according to their carbon number and number of double bonds by high performance reversed-phase chromatography (HPRC) using acetonitrile/chloroform/methanol (1:1:1, v/v) as a mobile phase. It was found that within the same equivalent carbon number (ECN) category, choles...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534908
更新日期:1981-08-01 00:00:00
abstract::The effect of SM-10661, a selective antagonist of platelet-activating factor (PAF), on passive anaphylactic bronchoconstriction was examined in guinea pigs. A challenge of ovalbumin to passively sensitized guinea pigs induced bronchoconstriction, which peaked at 4 min. When SM-10661 was administered intravenously 2 mi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536553
更新日期:1991-12-01 00:00:00
abstract::After administering the equivalent of 1 g of eicosapentaenoic acid (EPA) in four different chemical forms, the kinetics of EPA incorporation into plasma triglycerides (TG) were compared by gas liquid chromatography on a capillary column following separation of the lipid fraction by thin layer chromatography. EPA incor...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533970
更新日期:1987-10-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a collective term that describes different isomers of linoleic acid with conjugated double bonds. Although the main dietary isomer is 9cis,11trans-18:2, which is present in dairy products and ruminant fat, the biological effects of CLA generally have been studied using mixtures in whi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0759-8
更新日期:2001-06-01 00:00:00
abstract::Membrane lipids of photosynthetic organisms consist of glycerophospholipids and glyceroglycolipids. We investigated a method for the simultaneous quantitative analysis of neutral and acidic lipids using HPLC-ELSD, and quantified monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and sulfoquinovosyl...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3248-4
更新日期:2009-01-01 00:00:00
abstract::This study evaluated the effects of conjugated linoleic acids (CLA) on tissue fatty acid composition and ex vivo prostaglandin E2 (PGE2) production in rats given diets varying in n-6 and n-3 fatty acids. Four groups of rats were given a basal semipurified diet (AIN-93G) containing 70 g/kg of added fat for 42 d. The fa...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0223-9
更新日期:1998-04-01 00:00:00
abstract::A 10-hydroxy stearic acid-containing lipid from Cryptosporidium parvum was purified by thin-layer chromatography and analyzed by infrared spectroscopy, fast-atom bombardment mass spectrometry, 1H and 31P nuclear magnetic resonance spectroscopy, and was identified as phosphatidyl-ethanolamine. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0102-4
更新日期:1997-07-01 00:00:00
abstract::We have investigated the regulation of cholesterol synthesis in isolated human small intestine epithelial cells (enterocytes). It was established that the amount of cholesterol synthesized increased linearly with the incubation time and the number of cells in the incubation mixture; the synthesis was suppressed by 7-k...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535408
更新日期:1986-12-01 00:00:00
abstract::CDPcholine:1,2-diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is located on the cytoplasmic side of the endoplasmic reticulum, and catalyzes the final step in the synthesis of phosphatidylcholine via the CDPcholine pathway. The enzyme was solubilized from hamster liver microsomes by 3% Triton QS-15, and partial...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02562217
更新日期:1990-02-01 00:00:00
abstract::Peroxisome proliferator-activated receptor alpha (PPARalpha) belongs to the nuclear receptor superfamily that regulates multiple target genes involved in lipid metabolism. Cholesterol ester transfer protein (CETP) is a secreted glycoprotein that modifies high-density lipoprotein (HDL) particles. In humans, plasma CETP...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3187-0
更新日期:2008-07-01 00:00:00
abstract::This study reports the cloning, functional characterization, tissue expression, and nutritional regulation of a delta6 fatty acyl desaturase of Atlantic cod (Gadus morhua). PCR primers were designed based on the sequences of conserved motifs in available fish desaturases and used to isolate a cDNA fragment from cod li...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5051-4
更新日期:2006-11-01 00:00:00
abstract::Stimulation of platelets induces a rapid release of arachidonate from specific phospholipids and subsequent remodeling of arachidonate-containing phospholipids. This process is accompanied by transformation of released arachidonate by cyclooxygenase and lipoxygenase enzymes. We addressed the question of whether the cy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536506
更新日期:1991-12-01 00:00:00
abstract::Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532900
更新日期:1976-07-01 00:00:00
abstract::The objective of this study was to examine whether whole body oxidation rates of dietary linoleic, alpha-linolenic and oleic acids differ when the acids are provided in identical quantities. Male rats were fed for 10 wk a 15% fat (w/w) diet containing equal amounts of linoleic, alpha-linolenic and oleic acids (22.7, 2...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02578246
更新日期:1994-07-01 00:00:00
abstract::Schizochytrium sp. is an algae-like microorganism utilized for commercial production of docosahexaenoic acid (DHA)-rich oil and dried microalgae for use as a source of DHA in foods, feeds, and nutritional supplements. Electron microscopic analysis of whole cells of Schizochytrium sp. employing sample preparation by hi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0655-2
更新日期:2000-12-01 00:00:00
abstract::Rats were fed semipurified diets containing olive oil or partially hydrogenated corn oil at the 5 or 20% level for ca. 30 days. These fat diets contained the same amount of octadecenoate but differed in the geometry with respect to each fat level. Contents of t-18:1 were 26% and 41% of total fatty acids, respectively....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534500
更新日期:1984-02-01 00:00:00
abstract::Both diacyl GPC (glycerylphosphorylcholine) and diacyl GPE (glycerylphosphorylethanolamine) are synthesized in human placental tissue from their respective monoacyl precursors. The origin of the monacyl phosphatides is apparently not the result of placental phosphatide acyl-hydrolase activity. The most likely source i...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531854
更新日期:1967-09-01 00:00:00