Abstract:
:Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Sixty adult male Wistar rats were divided into six groups of 10 animals each: 1 sham-operated, NB diet; 2 sham-operated, PF diet; 3 total splenectomy (TS), NB diet; 4 TS, PF diet; 5 TS followed by splenic autotransplantation (SA), NB diet; and 6 SA, PF diet. Blood samples were collected at the beginning (D0) and after 12 weeks of the experiment (D + 12) for plasma lipid determination. Morphologic regeneration of splenic tissues was observed, with no differences between groups 5 and 6. When D + 12 plasma lipid levels were compared to D0 levels there were no differences in groups 1, 3, and 5, while in groups 2, 4, and 6 total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triacylglycerols (TAG) increased, and high density lipoprotein (HDL) decreased. At D + 12, groups 2, 4, and 6 had lower HDL than group 3. In conclusion, regardless of the surgical procedure applied to the spleen, an NB diet maintained plasma lipid levels while a diet with PF as source of lipids changed the animals' lipid profile.
journal_name
Lipidsjournal_title
Lipidsauthors
Dinis AP,Marques RG,Simões FC,Diestel CF,Caetano CE,Secchin DJ,Neto JF,Portela MCdoi
10.1007/s11745-009-3302-xsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
537-43issue
6eissn
0024-4201issn
1558-9307journal_volume
44pub_type
杂志文章相关文献
LIPIDS文献大全abstract::The evaluation of antioxidant activity in vivo is difficult. In this study, the effects of dietary natural and synthetic antioxidants on the lipid peroxidation in mice were assessed using a biomarker, total hydroxyoctadecadienoic acid (tHODE). Biological samples such as plasma, erythrocytes, and tissues were first red...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3043-7
更新日期:2007-05-01 00:00:00
abstract::The current study evaluated the composition and relationships of polyunsaturated fatty acid biohydrogenation products (PUFA-BHP) from the perirenal (PRF) and subcutaneous fat (SCF) of yearling steers fed a 70 % grass hay diet with concentrates containing either sunflower-seed (SS) or flaxseed (FS). Analysis of varianc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3876-1
更新日期:2014-03-01 00:00:00
abstract::Stearoyl-coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. Recently, SCD1 down-regulation has been implicated in the prevention of obesity, and the improvement of insulin and leptin sensitivity. In this study, we examined...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3784-4
更新日期:2013-05-01 00:00:00
abstract::Tris(N,N-dimethyl)amide of phosphorous acid activated by addition of iodine at an optimal molar ratio of 1.05:0.05 was used as a phosphorylating reagent to synthesize cholecalciferyl-3-O-(1-2-isopropylidene-rac-glycero-3-O-)-thiophos phate and cholecalciferyl-3-O-(1,2-dipalmitoyl-rac-glycero-3-O-)thiophosphat e of met...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536388
更新日期:1992-06-01 00:00:00
abstract::The aim of this study was to determine the effects of an omega-3 (n-3) polyunsaturated fatty acid (PUFA)-enriched diet on animal fat depots and lipid oxidation in the blood and meat of broiler chickens. Abdominal fat pad (AFP), sartorius muscle and liver histology were used to assess the effect of the dietary fat on a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3785-3
更新日期:2013-07-01 00:00:00
abstract::A sucrose-rich diet (SRD) induces insulin resistance and dyslipidemia with impaired hepatic glucose production and gluconeogenesis, accompanied by altered post-receptor insulin signaling steps. The aim of this study was to examine the effectiveness of fish oil (FO) to reverse or improve the impaired hepatic glucose me...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-011-3623-4
更新日期:2012-02-01 00:00:00
abstract::Trilinoleoylglycerol (LLL), trilinolenoylglycerol (LnLnLn) and four synthetic triacylglycerols were autoxidized and the volatile products were investigated to determine the effect of fatty acid glyceride position on the mechanism of hydroperoxide decomposition. Capillary gas chromatography provided a sensitive method ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536386
更新日期:1992-06-01 00:00:00
abstract::The physiological role of long-chain fatty acyl-CoA is thought to be primarily in intermediary metabolism of fatty acids. However, recent data show that nM to microM levels of these lipophilic molecules are potent regulators of cell functions in vitro. Although long-chain fatty acyl-CoA are present at several hundred ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522684
更新日期:1996-09-01 00:00:00
abstract::Dietary fatty acids have different effects on fat deposition in pigs. To clarify the underlying mechanisms of this difference, we compared the metabolism of palmitic (PAM, saturated), oleic (OLA, monounsaturated) and linoleic acid (LNA, polyunsaturated) in porcine adipocytes treated with 100 μM PAM, OLA or LNA. We obs...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4302-x
更新日期:2017-11-01 00:00:00
abstract::The synthesis of thioether phospholipids, which represent a new class of antitumor agents, is reported here. In particular, the route of synthesis of 3-hexadecylmercapto-2-methoxymethylpropyl-2'-trimethylammoni o-ethyl phosphate (BM 41.440, Ilmofosine), one of the most potent cytostatic/cytotoxic derivatives, is descr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535561
更新日期:1987-11-01 00:00:00
abstract::The artificial rearing model was used to investigate the effects of short-term exposure to ethanol on growth and fatty acid composition of forebrain (FB) and cerebellum (CB) during the brain growth spurt in either n-3 fatty acid-adequate (AD) or n-3 deficient (DEF) rat pups. On postnatal day 5, offspring of female rat...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0469-2
更新日期:1999-11-01 00:00:00
abstract::Lifibrol, a new hypocholesterolemic agent with activity in humans, was examined in normal rats for its short-term and long-term effects on lipid homeostasis. Cholesterol (Chol) synthesis inhibition by lifibrol was demonstrated in vitro in liver minces from normal rats by following [1-14C]acetate ([14C]Ac) and DL-[2-14...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537074
更新日期:1993-12-01 00:00:00
abstract::The effects of feeding CLA to hens on newly hatched chick hepatic and carcass lipid content, liver TAG accumulation, and FA incorporation in chick tissues such as liver, heart, brain, and adipose were studied. These tissues were selected owing to their respective roles in lipid assimilation (liver), as a major oxidati...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1367-3
更新日期:2005-02-01 00:00:00
abstract::A method is described for the separation, identification, and quantitative estimation of the individual molecular species occurring in natural lecithin mixtures. Purified lecithin preparations are converted into diglyceride acetates by enzymic dephosphorylation and acetylation. The diglyceride acetates are separated o...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532559
更新日期:1967-05-01 00:00:00
abstract::Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury, and infection in some individuals and these can lead, progressively, to sepsis and septic shock. The hyperinflammation is characterized by the production of inflammatory cytokines, arachidonic acid-...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1342-z
更新日期:2004-12-01 00:00:00
abstract::Previous research in rats and mice has suggested that gamma-linolenic acid (GLA) derived from borage oil (BO: 23% GLA) may be an appropriate source for increasing levels of long-chain n-6 FA in the developing brain. Recently, transgenic technology has made available a highly enriched GLA seed oil from the canola plant...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1048-2
更新日期:2003-02-01 00:00:00
abstract::Total lipid content in the thermophilic fungi-Thermoascus aurantiacus, Humicola lanuginosa, Malbranchea pulchella var.sulfurea, andAbsidia ramosa-varied from 5.3 to 19.1% of mycelial dry weight. The neutral and polar lipid fractions accounted for 56.4 to 80.2% and 19.8 to 43.6%, respectively. All the fungi contained m...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533048
更新日期:1976-10-01 00:00:00
abstract::This study reports the cloning, functional characterization, tissue expression, and nutritional regulation of a delta6 fatty acyl desaturase of Atlantic cod (Gadus morhua). PCR primers were designed based on the sequences of conserved motifs in available fish desaturases and used to isolate a cDNA fragment from cod li...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5051-4
更新日期:2006-11-01 00:00:00
abstract::alpha-Monoolein was prepared from glycidol and oleic acid by the regioselective opening of glycidol in the presence of an anionic resin. During the reaction, the lipochemical synthesis medium becomes enriched in monoolein, the effective emulsifying agent. This mixture can be analyzed by thin-layer chromatography coupl...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522406
更新日期:1996-01-01 00:00:00
abstract::Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1223-5
更新日期:2004-03-01 00:00:00
abstract::Fatty acids of Ophiuroidea (brittle star) Ophiura sarsi have been investigated by gas-liquid chromatography (GLC). About 2-13% of four unidentified fatty acids were found in total fatty acids from a sample caught at a depth of 1,100 m. Structural analyses were undertaken after partial hydrogenation of their concentrat...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0854-x
更新日期:2001-12-01 00:00:00
abstract::Recently, a number of inhibitors of the enzyme oxidosqualene cyclase (OSC; EC 5.4.99.7), a key enzyme in sterol biosynthesis, were shown to inhibit in mammalian cells the multiplication of Trypanosoma cruzi, the parasite agent of Chagas' disease. The gene coding for the OSC of T. cruzi has been cloned and expressed in...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1493-y
更新日期:2005-12-01 00:00:00
abstract::Lipoxygenase was isolated and partially purified from peanut seed by ammonium sulfate precipitation, gel filtration, and ion exchange column chromatography. Three isozymes of lipoxygenase were identified. Two had pH optima of 6.2, and the other an optimum of 8.3. Molecular weight of each isozyme was 7.3 x 10(4), as de...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532761
更新日期:1975-11-01 00:00:00
abstract::The biosynthesis of [14C] CDP-diglyceride was studied using rat liver microsomes which were endogenously labeled with [14C] phosphatidic acid by preincubation of unlabeled microsomes with sn-[14C] glycerol-3-phosphate and appropriate cofactors. The formation of CDP-diglyceride from radioactive phosphatidate showed an ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544050
更新日期:1976-04-01 00:00:00
abstract::The pyrrolidide and picolinyl ester derivatives of the fatty acids in two natural lipid samples rich in unsaturated fatty acids, pig testis lipids and cod liver oil were satisfactorily resolved on capillary columns of fused silica coated with stationary phases of varying polarity. The picolinyl esters, in particular, ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537217
更新日期:1986-10-01 00:00:00
abstract::The naturally occurring (6Z)-(±)-2-methoxy-6-hexadecenoic acid (1) and (6Z)-(±)-2-methoxy-6-octadecenoic acid (2) were synthesized in 7-8 steps with 38 and 13% overall yields, respectively, by using an acetylide coupling approach, which made it possible to obtain a 100% cis-stereochemistry for the double bonds. In a s...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4262-1
更新日期:2017-06-01 00:00:00
abstract::Microsomal and myelin membrane fractions were prepared from the brains of warm-adapted (room temperature) and hibernating Syrian Hamsters (Mesocricetus auratus). Ethanolamineglycerophospholipids were isolated and subjected to a fractionation scheme to separate the fatty acids of the plasmenylethanolamine and the phosp...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533441
更新日期:1979-12-01 00:00:00
abstract::When the sewage fungus Leptomitus lacteus was grown in liquid culture aerobically and then transferred to medium containing long-chain fatty acids, it produced a number of oxygenated fatty acids. From linoleic acid (18:2n-6), the major metabolite produced was R-8-hydroxy-9Z,12Z-octadecadienoic acid (8R-HODE), with add...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0490-5
更新日期:2000-01-01 00:00:00
abstract::To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in "non-proliferative" and "proliferative" cells in the large intestine, Sprague-Dawley rats were fed diets providing a polyunsaturated-to-saturated fatty acid ratio of 1.2 or 0.3 at a high or low level of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536069
更新日期:1991-06-01 00:00:00
abstract::Chemical composition of subcellular components of HeLa, KB, human heart and liver tissue-culture cell lines have been studied.The concentration of RNA, protein and phospholipid (mug/mug of DNA) of total subcellular particles was similar for all four cell lines studied. The greatest RNA concentration and lowest protein...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531999
更新日期:1967-01-01 00:00:00