Abstract：
:Lifibrol, a new hypocholesterolemic agent with activity in humans, was examined in normal rats for its short-term and long-term effects on lipid homeostasis. Cholesterol (Chol) synthesis inhibition by lifibrol was demonstrated in vitro in liver minces from normal rats by following [1-14C]acetate ([14C]Ac) and DL-[2-14C]mevalonate ([14C]-MVA) incorporation into [14C]Chol. When administered at 50 mg/kg/d, lifibrol reduced plasma total Chol and triglycerides (TG) (P < 0.001) within 24 h. The Chol reduction was largely a result of reduction of low density and very low density lipoprotein cholesterol (LDL + VLDL-chol) and a smaller decrease in high density lipoprotein cholesterol (HDL-chol). After 10 d, however, a rebound effect emerged, and after 41 d, plasma Chol, LDL + VLDL-chol, and HDL-chol were restored. In contrast, plasma TG remained at reduced levels (P < 0.01). The rebound is attributed to counter-regulation of hepatic sterologenesis that was assessed both ex vivo and in vivo. The ex vivo incorporation of [14C]MVA and [14C]octanoate into [14C]Chol and total digitonin-precipitable [14C]sterols ([14C]DPS) in liver minces was increased 2-and 6-fold, respectively, in rats treated 6 d at 50 mg/kg. Similarly, in vivo incorporation of intraperitoneally injected [14C]Ac into hepatic [14C]DPS (2 h post-injection) was increased 2- to 5-fold at 50 mg/kg, and evidence for increased sterologenesis in nonhepatic tissue was also obtained. The increased hepatic sterologenesis, evident within 48 h, persisted out to 41 d of treatment by which time increases (P < 0.002) in hepatic Chol and carcass total sterols were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Lipidsjournal_title
Lipidsauthors
Bell FP,St John LCdoi
10.1007/BF02537074subject
Has Abstractpub_date
1993-12-01 00:00:00pages
1079-85issue
12eissn
0024-4201issn
1558-9307journal_volume
28pub_type
杂志文章相关文献
LIPIDS文献大全abstract：:Studies are reported on the capacity of isolated rat renal papilla (inner medulla) to synthesize and release prostaglandin (PG) E from endogenous and exogenous precursor(s) during development of an essential fatty acid (EFA) deficiency in the rat. Weanling (21-day-old) male Sprague-Dawley rats were fed a fat-free diet...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533845
更新日期：1978-12-01 00:00:00
abstract：:Polar lipids of bacteria from the class Thermomicrobia are known to contain long-chain 1,2-diols instead of glycerol, although the nature of polar head groups has not been investigated. We have studied phospholipid classes of two species from the class Thermomicrobia-Sphaerobacter thermophilus and Thermomicrobia sp. W...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-014-3979-3
更新日期：2015-03-01 00:00:00
abstract：:This study was carried out to investigate the effects of a dietary oxidized oil on lipid metabolism in rats, particularly the desaturation of fatty acids. Two groups of rats were fed initially for a period of 35 d diets containing 10% of either fresh oil or thermally treated oil (150 degrees C, 6 d). The dietary fats ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-999-0418-0
更新日期：1999-07-01 00:00:00
abstract：:The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar lev...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02637097
更新日期：1996-03-01 00:00:00
abstract：:Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-014-3889-4
更新日期：2014-05-01 00:00:00
abstract：:The activity of lysosomal acid cholesteryl ester hydrolase (acid CEH, EC 3.1.1.13) in rat liver was determined at 3, 5, 7, 10 and 20 wk following birth. The levels of acid CEH activity showed a marked decrease as rats grew older, whereas those of other lysosomal marker enzymes, such as acid phosphatase, beta-glucuroni...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533950
更新日期：1987-09-01 00:00:00
abstract：:The present study enumerates the synthesis, spectroscopic characterization, and evaluation of anticancer potential of esters of two n-9 fatty acids viz., oleic acid (OLA) and ricinoleic acid (RCA) with 2,4- or 2,6-diisopropylphenol. The synthesis strategy involved esterification of the hydroxyl group of diisopropylphe...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-012-3707-9
更新日期：2012-10-01 00:00:00
abstract：:Serum high density lipoprotein is increasingly recognized as a negative risk for cardiovascular disease. The distribution and interrelationship of serum lipids, lipoproteins, anthropometric measurements and blood pressures were determined in some 5,000 children. Children had mean +/- S.D. alpha-lipoprotein cholesterol...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533576
更新日期：1979-01-01 00:00:00
abstract：:Fatty acid alpha-hydroxylase from Sphingomonas paucimobilis is an unusual cytochrome P450 enzyme that hydroxylates the alpha-carbon of fatty acids in the presence of H2O2. Herein, we describe our investigation concerning the utilization of various substrates and the optical configuration of the alpha-hydroxyl product ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-000-533-y
更新日期：2000-04-01 00:00:00
abstract：:Phosphatidylinositol (PtdIns) and phosphatidylinositol 4-phosphate (PtdIns4P) kinase activities in plasma membranes isolated from canine left ventricle were partially characterized, and their sensitivity to a number of intracellular variables was established. PtdIns and PtdIns4P kinase activities were estimated by the...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02544590
更新日期：1989-09-01 00:00:00
abstract：:It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02543975
更新日期：1991-03-01 00:00:00
abstract：:Usually, the chemical structures of cerebrosides in sea creatures are more complicated than those from terrestrial plants and animals. Very little is known about the method for high-throughput molecular profiling of cerebrosides in sea cucumbers. In this study, cerebrosides from four species of edible sea cucumbers, s...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-015-4039-3
更新日期：2015-07-01 00:00:00
abstract：:Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-998-0250-6
更新日期：1998-06-01 00:00:00
abstract：:The fatty acid (FA) profile of oysters generally reflects the dietary FA composition. Moreover, incorporation of FA into tissues is modulated by various metabolic factors, and final composition will depend upon the dietary sources, cumulative intake, and oysters' development stage. Thus, the aim of this study was to a...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1002/lipd.12177
更新日期：2019-09-01 00:00:00
abstract：:A group of Angus beef cattle was removed from temperate pastures and fed a very low beta-carotene cereal-based ration in a feedlot for over 300 d. Half the group was supplemented weekly with retinyl palmitate (at the rate of 60,000 IU vitamin A/100 live weight (LW)/day), sufficient to offset clinical vitamin A deficie...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-006-5107-5
更新日期：2006-04-01 00:00:00
abstract：:The seed oil ofEuonymus verrucosus Scop., family Celastraceae, contains more than 90% 1,2-diacyl-3-acetins (monoacetotriglycerides). The constituent triglyceride acids, other than acetic, are the usual long-chain fatty acids.Thin-layer chromatography (TLC), infrared (IR) and hydrolysis with pancreatic lipase indicate ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02533174
更新日期：1967-11-01 00:00:00
abstract：:Cholesterol biosynthesis from acetate-2-(14)C by the livers of suckling rats, which is known to be relatively slow, was increased 2-3-fold within 24 hours after severing the bile duct. Cholesterol synthesis by sham-operated litter mates showed no change under similar treatment. Mevalonate biosynthesis from acetate-2-(...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02530913
更新日期：1967-03-01 00:00:00
abstract：:An experiment examined delta9 desaturase activity and FA composition in subcutaneous adipose tissue in two differing breeds of cattle. Jersey-sired cattle had significantly higher rates of desaturase activity than Limousin-sired cattle (1.55 vs. 0.75 nmol/mg protein/min). This difference was also demonstrated by a low...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-003-1339-7
更新日期：2003-05-01 00:00:00
abstract：:Vegetable oils are one of the main agricultural commodities. Demand has been increasing steadily over the last five decades and, with finite land available, it is vital that we increase productivity. My laboratory has focused on the regulation of plant lipid metabolism and, as part of this work, we identified diacylgl...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1002/lipd.12267
更新日期：2020-09-01 00:00:00
abstract：:The reaction products of alpha-tocopherol and its model compound, 2,2,5,7,8-pentamethylchroman-6-ol, during the autoxidation of methyl linoleate at 37 C were investigated. Two isomeric trimers were obtained as the major reaction products of alpha-tocopherol, and a trimer was obtained as that of its model chroman. The ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02536221
更新日期：1988-08-01 00:00:00
abstract：:1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) is known to stimulate platelet aggregation and serotonin release in concentrations ranging from 10(-10)-10(-5) M. Since a variety of synthetic PAF analogues are potent antineoplastic agents in vitro and in vivo, it was the aim of th...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02535546
更新日期：1987-11-01 00:00:00
abstract：:Guar gum has a well-recognized hypolipidemic effect. This effect is thought to be due to the physicochemical properties of guar gum, which may cause changes in adsorption of lipids or the viscosity of the intestinal contents. Guar gum is a non-specific absorption inhibitor of any type of lipid-soluble compound. Perman...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-011-3570-0
更新日期：2011-08-01 00:00:00
abstract：:Lipophilic toxins have been introduced into the environment both as functional compounds, such as pesticides, and as industrial waste from incineration or the manufacture of electrical transformer components. Among these substances are compounds that are carcinogenic and that affect the endocrine system. Accidental hi...
journal_title：Lipids
pub_type： 杂志文章,评审
doi：10.1007/s11745-001-0844-z
更新日期：2001-12-01 00:00:00
abstract：:Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to determine if 39 g soy (85 mg aglycone isoflavones, treatment) compar...
journal_title：Lipids
pub_type： 临床试验,杂志文章
doi：10.1007/s11745-006-5095-5
更新日期：2006-03-01 00:00:00
abstract：:This study investigated a possible role for the epidermal growth factor (EGF) receptor protein tyrosine kinase in phosphoinositide metabolism with plasma membrane vesicles from human epidermoid carcinoma (A431) cells. We found a novel chloroform-soluble product radiolabeled with [gamma-32P]ATP that did not migrate fro...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/BF02534242
更新日期：1985-07-01 00:00:00
abstract：:Previous reports have suggested that cargo-free cationic nanoparticles (cNP) consisting of cationic monovalent lipids, such as 1,2-oleoyl-3-trimethylammonium-propane (DOTAP), induce reactive oxygen species (ROS) generation and toxicity in cells. In addition, cNP containing six lysine residues (6K) and cargo (6K-cNP) e...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1002/lipd.12124
更新日期：2018-11-01 00:00:00
abstract：:Hydrolysis of symmetrical acetylenic TG of type AAA [viz., glycerol tri-(4-decynoate), glycerol tri-(6-octadecynoate), glycerol tri-(9-octadecynoate), glycerol tri-(10-undecynoate), and glycerol tri-(13-docosynoate)] in the presence of eight microbial lipases was studied. Novozyme 435 (Candida antarctica), an efficien...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-006-0992-1
更新日期：2002-10-01 00:00:00
abstract：:Steroids bearing ketone functionality at carbon-7 are found commonly in nature, and the most prevalent of these are the 7-keto-delta5-sterols. These substances have diverse biological properties and are present in biological samples and food products. For the purpose of studying this class of oxysterols, many chemical...
journal_title：Lipids
pub_type： 杂志文章,评审
doi：10.1007/s11745-004-1299-y
更新日期：2004-08-01 00:00:00
abstract：:The tissue distribution of newly synthesized 22:6n-3 and intermediate PUFA was examined in rainbow trout to further our understanding of the metabolism of this EFA in fish. Rainbow trout were fed a pulse of deuterated linolenic acid (D5-17,17,18,18,18-18:3n-3), and the tissue distribution of deuterated anabolites was ...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-003-1146-1
更新日期：2003-09-01 00:00:00
abstract：:HMG-CoA reductase (HMGCR) is an enzyme involved in cholesterol synthesis. To investigate the contribution of the HMGCR gene to lipids and lipoprotein subfractions in different ethnicities, we performed an association study in the Multi-Ethnic Study of Atherosclerosis (MESA). In total, 2,444 MESA subjects [597 African-...
journal_title：Lipids
pub_type： 杂志文章
doi：10.1007/s11745-009-3314-6
更新日期：2009-08-01 00:00:00
