Synthesis and characterization of novel n-9 fatty acid conjugates possessing antineoplastic properties.

abstract：:The present studies tested the hypothesis that some effects of tumor necrosis factor-alpha (TNF-alpha) are mediated by activation of sphingomyelinases and the production of ceramides. Differentiated 3T3-L1 adipocytes were incubated with short-chain ceramide analogs, (C2- and C6-ceramides: N-acetyl- and N-hexanoyl-sphi...

journal_title：Lipids

authors： Brindley DN,Wang CN,Mei J,Xu J,Hanna AN

更新日期：1999-01-01 00:00:00

abstract：:The effect of dietary n-3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n-3 treatments were formulated with added alpha-linol...

journal_title：Lipids

authors： Li Y,Greiner RS,Salem N Jr,Watkins BA

更新日期：2003-06-01 00:00:00

abstract：:The fatty acid composition of cerebrosides of developing foetal human brain and regional variations, if any, during intrauterine life were studied. While palmitic and stearic acids were the predominant normal fatty acids throughout intrauterine life, long chain fatty acids, like lignoceric and nervonic acids, which we...

journal_title：Lipids

authors： Rao PS

更新日期：1977-04-01 00:00:00

abstract：:In the present study, changes in phospholipid compositions of liver microsomes, erythrocyte membranes, platelets, aorta, cardiac muscle and brain of rats fed olive oil were compared with those of rats fed sunflower oil. Four groups of rats starting at weaning were fed for four weeks a basal diet containing 5 or 25% ol...

journal_title：Lipids

authors： Navarro MD,Periago JL,Pita ML,Hortelano P

更新日期：1994-12-01 00:00:00

abstract：:Developing rat brain has the capacity for either delta 9 or delta 6 desaturation of fatty acids. In liver, evidence supports the existence of separate enzymes for each reaction, but it is not known whether in brain delta 9 or delta 6 desaturation of saturated fatty acids involves distinct enzymes. We have used fatty a...

journal_title：Lipids

authors： Cook HW

更新日期：1979-09-01 00:00:00

abstract：:We studied the actions of oxysterols on fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells. Cultures were labeled with [1-14C]arachidonate or [1-14C]oleate. During a 24-hr incubation, 25- or 22R-hydroxycholesterol enhanced the incorporation of label into triglycerides, concomitan...

journal_title：Lipids

authors： Seillan C

更新日期：1990-03-01 00:00:00

abstract：:Oxidized LDL (oxLDL) has been shown to activate the sphingomyelinase pathway producing ceramide in vascular smooth muscle cells. Therefore ceramide, which is a biologically active lipid causing apoptosis in a variety of cells, may be involved in the apoptotic action of oxLDL. In this study, we examined whether cholest...

journal_title：Lipids

authors： Ichi I,Takashima Y,Adachi N,Nakahara K,Kamikawa C,Harada-Shiba M,Kojo S

更新日期：2007-10-01 00:00:00

abstract：:Jasmonic acid (JA) is synthesized from linolenic acid (18:3n-3) by sequential action of 13-lipoxygenase, allene oxide synthase (AOS), and allene oxide cyclase. The fungus Lasiodiplodia theobromae can produce large amounts of JA and was recently reported to form the JA precursor 12-oxophytodienoic acid. The objective o...

journal_title：Lipids

authors： Jernerén F,Eng F,Hamberg M,Oliw EH

更新日期：2012-01-01 00:00:00

abstract：:The stereochemistry of fat digestion and absorption was investigated in rats with thoracic duct fistulas, after feeding synthetic triacylglycerol or alkyldiacylglycerol. After feeding 1,2-dilauroyl-3-oleoyl-sn-glycerol, dilauroyloleoylglycerol and lauroyldioleoylglycerol were the most abundant chyle triacylglycerols. ...

journal_title：Lipids

authors： Akesson B,Gronowitz S,Herslof B,Ohlson R

更新日期：1978-05-01 00:00:00

abstract：:Trilinoleoylglycerol (LLL), trilinolenoylglycerol (LnLnLn) and four synthetic triacylglycerols were autoxidized and the volatile products were investigated to determine the effect of fatty acid glyceride position on the mechanism of hydroperoxide decomposition. Capillary gas chromatography provided a sensitive method ...

journal_title：Lipids

authors： Frankel EN,Selke E,Neff WE,Miyashita K

更新日期：1992-06-01 00:00:00

abstract：:This review covers the work of our laboratory on the antineoplastic activity of some ether lipids and derivatives that are related to platelet-activating factor (PAF). Various 1-O-alkyl lysophospholipid derivatives (ALP) show therapeutic activity in mouse transplant tumor models and in metastatic 3-Lewis lung carcinom...

journal_title：Lipids

authors： Berdel WE

更新日期：1987-11-01 00:00:00

abstract：:The effects of increasing concentrations of eicosapentaenoic acid (20:5n-3; EPA) and oleic acid (18:1n-9; OA) on esterification to triacylglycerols (TG) and phospholipids (PL), and the relationship to formation and secretion of the very low density lipoproteins (VLDL) were compared in the isolated perfused rat liver. ...

journal_title：Lipids

authors： Zhang ZJ,Wilcox HG,Castellani L,Fungwe TV,Elam MB,Heimberg M

更新日期：1993-05-01 00:00:00

abstract：:Phosphatidylinositol (PtdIns) and phosphatidylinositol 4-phosphate (PtdIns4P) kinase activities in plasma membranes isolated from canine left ventricle were partially characterized, and their sensitivity to a number of intracellular variables was established. PtdIns and PtdIns4P kinase activities were estimated by the...

journal_title：Lipids

authors： Kasinathan C,Xu ZC,Kirchberger MA

更新日期：1989-09-01 00:00:00

abstract：:In an attempt to combine the hypocholesterolemic properties of plant sterols with the hypotriglyceridemic action of fish oil FA, plant sterols have recently been esterified to fish oil n-3 PUFA. The objective of this study was to determine the effects of plant sterols esterified to n-3 PUFA on plasma lipid levels and ...

journal_title：Lipids

authors： Demonty I,Ebine N,Jia X,Jones PJ

更新日期：2005-07-01 00:00:00

abstract：:A new triterpene alcohol was isolated fron shea butter and its structure was shown to be 24-methylenelanost-9(11)-en-3beta-ol. Gas chromatographic correlations between this triterpene alcohol and other related compounds are discussed. ...

journal_title：Lipids

authors： Itoh T,Tamura T,Matsumoto T

更新日期：1975-08-01 00:00:00

abstract：:Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...

journal_title：Lipids

authors： Smith LL

更新日期：1996-05-01 00:00:00

abstract：:A group of homologous, nonmethylene-interrupted dienoic fatty acids (NMID) recently reported in oysters has been found in several other shellfish species and also in other marine phyla. The distribution of most other "normal" fatty acids among several species of shellfish is basically similar but mantle lipids from tw...

journal_title：Lipids

authors： Paradis M,Ackman RG

更新日期：1977-02-01 00:00:00

abstract：:Ceramides are a family of signalling lipids with diverse physiological functions that include pro-differentiative and pro-apoptotic signalling. Ceramides and their derivatives are major constituents of myelin, maintaining neuronal conductivity. Ceramides are synthesized by ceramide synthases, of which there are six is...

journal_title：Lipids

authors： Couttas TA,Lim XY,Don AS

更新日期：2015-01-01 00:00:00

abstract：:The acylation of lysophospholipids by rat liver acyltransferases was studied. A comparison between ester and ether lysophospholipids as substrates revealed large differences in substrate properties. For instance, oleic acid from oleoyl-CoA and arachidonic acid from arachidonoyl-CoA were not incorporated into 1-O-octad...

journal_title：Lipids

authors： Neumüller W,Fleer EA,Unger C,Eibl H

更新日期：1987-11-01 00:00:00

abstract：:Previous studies from our laboratory have shown that retinitis pigmentosa (RP), a family of hereditary retinal degenerations, is often accompanied by abnormal levels of cholesterol or polyunsaturated fatty acids. The requirement of the retina for n-3 fatty acids is well known, and a defect in the supply of these lipid...

journal_title：Lipids

authors： Huq L,McLachlan T,Hammer HM,Bedford D,Packard CJ,Shepherd J,Converse CA

更新日期：1993-11-01 00:00:00

abstract：:Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups a...

journal_title：Lipids

authors： Pereira AD,Ribeiro DC,de Santana FC,de Sousa Dos Santos A,Mancini-Filho J,do Nascimento-Saba CC,Velarde LG,da Costa CA,Boaventura GT

更新日期：2016-08-01 00:00:00

abstract：:A fluorescent radiolabeled triacylglycerol has been synthesized by using a fluorescent fatty acid (pyrene decanoic acid) and a radiolabeled oleic acid. This analog of the natural substrate, 1(3)pyrene decanoic-2,3 (1,2)-dioleoyl-sn-glycerol, has been tested as substrate for determining lipoprotein lipase and hepatic t...

journal_title：Lipids

authors： Dousset N,Negre A,Salvayre R,Rogalle P,Dang QQ,Douste-Blazy L

更新日期：1988-06-01 00:00:00

abstract：:Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300% with each diet. Changes in serum concentrations of Sf 20+ and Sf 0-20 lip...

journal_title：Lipids

authors： Goldsmith DP,Jacob HP

更新日期：1978-03-01 00:00:00

abstract：:The conversion of labeled palmitic, linoleic, arachidonic and docosahexaenoic acids to their respective acyl CoA's was studied in homogenates and microsomes of rat tissues. The highest activity, both in homogenates and microsomes, was seen in liver and heart. There was moderate activity in retina, brain, lung, kidney ...

journal_title：Lipids

authors： Reddy TS,Bazan NG

更新日期：1984-12-01 00:00:00

abstract：:The content and positional distribution of CLA in TAG fractions of lamb tissues was examined with either preformed CLA or the linoleic acid precursor of CLA in the diet as experimental treatments. The CLA content of phospholipid (PL) from these tissues was also examined. Thirteen lambs were randomized to the following...

journal_title：Lipids

authors： Paterson LJ,Weselake RJ,Mir PS,Mir Z

更新日期：2002-06-01 00:00:00

abstract：:Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to determine if 39 g soy (85 mg aglycone isoflavones, treatment) compar...

journal_title：Lipids

authors： Campbell CG,Brown BD,Dufner D,Thorland WG

更新日期：2006-03-01 00:00:00

abstract：:The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

journal_title：Lipids

authors： Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

更新日期：1995-09-01 00:00:00

abstract：:Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...

journal_title：Lipids

authors： Alonso A,Martínez-González MA

更新日期：2004-12-01 00:00:00

abstract：:The objective of this study was to establish the impact of caloric restriction on high fat diet-induced alterations on regulators of skeletal muscle growth. We hypothesized that caloric restriction would reverse the negative effects of high fat diet-induced obesity on REDD1 and mTOR-related signaling. Following an ini...

journal_title：Lipids

authors： Dungan CM,Li J,Williamson DL

更新日期：2016-08-01 00:00:00

abstract：:Previous studies show that long term variations in dietary fat consumption impact circulating fatty acid ethanolamide (FAE) concentrations, however, few studies have investigated short term effects of dietary fat feeding on FAE levels. The trial's objective was to explore the effect of acute feeding of varying amounts...

journal_title：Lipids

authors： Olatinsu AO,Sihag J,Jones PJH

更新日期：2017-11-01 00:00:00