Activation of polyunsaturated fatty acids by rat tissues in vitro.

Abstract:

:The conversion of labeled palmitic, linoleic, arachidonic and docosahexaenoic acids to their respective acyl CoA's was studied in homogenates and microsomes of rat tissues. The highest activity, both in homogenates and microsomes, was seen in liver and heart. There was moderate activity in retina, brain, lung, kidney and testes and the lowest activity was found in spleen. Docosahexaenoic acid was activated much less actively in heart tissue than the other fatty acids. In all tissues examined, the highest activation was observed with arachidonic acid and the lowest with docosahexaenoic acid. Except for liver, those tissues that contained high levels of docosahexaenoic acid also had the highest activation capacity for this fatty acid.

journal_name

Lipids

journal_title

Lipids

authors

Reddy TS,Bazan NG

doi

10.1007/BF02534740

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

987-9

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

19

pub_type

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