Preferential redistribution of lipoprotein-unassociated apoA-IV to an HDL subpopulation with a high degree of LCAT modification.

Abstract:

:The relationship between LCAT mediated HDL modification and the redistribution of lipoprotein-unassociated apoA-IV to HDL was investigated in vitro. Immunoaffinity-isolated rat lipoprotein-unassociated apoA-IV was added to apoB-, apoE-, apoA-IV depleted, [3H]cholesterol labelled rat plasma and incubated at 37 degrees C. The addition of lipoprotein-unassociated apoA-IV resulted in a modest (10%) but significant reduction in the rate of cholesterol esterification. Incubations conducted in the presence of active LCAT led to a time-dependent increase in the amount of the 3H label retained by an anti-apoA-IV immunoaffinity column. Lipoproteins retained by the anti-apoA-IV immunoaffinity column had experienced a greater conversion of [3H]cholesterol to [3H]cholesteryl esters (48% esterification at 30 min) than the unretained lipoproteins (19% esterification at 30 min). These data suggest that during the course of LCAT-induced cholesterol esterification, lipoprotein-unassociated apoA-IV transfers to a subpopulation of HDL which has been modified by LCAT to a greater extent than the remaining HDL. Further analysis of the data demonstrates that 48% cholesterol esterification is sufficient to allow apoA-IV to be accommodated on the surface of an HDL particle.

journal_name

Lipids

journal_title

Lipids

authors

Lefevre M,Goudey-Lefevre JC,Roheim PS

doi

10.1007/BF02544075

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1035-8

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

24

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Rapid and improved method for the determination of bile acids in human feces using MS.

    abstract::A simple method for the determination of bile acids in adult human fecal samples using GC-MS is described. Bile acids are directly extracted from feces by ethanol (95%) containing 0.1 N NaOH. Extracts are purified by passage through a reversed-phase C18 silica cartridge and then analyzed by GC-MS. The present study ha...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-002-1005-0

    authors: Perwaiz S,Mignault D,Tuchweber B,Yousef IM

    更新日期:2002-11-01 00:00:00

  • Application of new methods and analytical approaches to research on polyunsaturated fatty acid homeostasis.

    abstract::New methods and analytical approaches are important to challenge and/or validate established beliefs in any field including the metabolism of polyunsaturated fatty acids (PUFA; polyunsaturates). Four methods that have recently been applied toward obtaining a better understanding of the homeostasis of PUFA include the ...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-001-0808-3

    authors: Cunnane SC

    更新日期:2001-09-01 00:00:00

  • Mechanisms of linoleic acid uptake by rabbit small intestinal brush border membrane vesicles.

    abstract::We examined the initial transport of a long-chain unsaturated fatty acid, linoleic acid, by brush border membrane vesicles isolated from rabbit small intestine. This preparation allowed us to examine the transport of linoleic acid across the brush border membrane without the effect of the unstirred water layer or cyto...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535264

    authors: Ling KY,Lee HY,Hollander D

    更新日期:1989-01-01 00:00:00

  • Resolution of molecular species of intact serine and ethanolamine phosphatides by argentation chromatography of their trifluoroacetamides.

    abstract::An effective resolution of intact phosphatidylserines on the basis of unsaturation has been achieved by conventional argentation thin layer chromatography (TLC) following trifluoracetylaction. The trifluoroacetamides are prepared by treatment with trifluoroacetic anhydride or N-methyl-bis-trifluoroacetamide. The aceta...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533377

    authors: Yeung SK,Kuksis A,Marai L,Myher JJ

    更新日期:1977-07-01 00:00:00

  • Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling.

    abstract::An important enzyme involved in phospholipid turnover is the acyl-CoA: lysophosphatidylcholine acyltransferase (LPCAT). Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-008-3233-y

    authors: Kazachkov M,Chen Q,Wang L,Zou J

    更新日期:2008-10-01 00:00:00

  • Lysophosphatidylcholine accumulation in the ischemic canine heart.

    abstract::The production of cardiac arrhythmias and the elevation of lysophosphatidylcholine level in the ischemic myocardium have been well-documented in a number of studies. However, the relationship between the production arrhythmias and the elevation of tissue lysophosphatidylcholine level was not reported. In this study, t...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535301

    authors: Kinnaird AA,Choy PC,Man RY

    更新日期:1988-01-01 00:00:00

  • Maternal high-fat-diet programs rat offspring liver fatty acid metabolism.

    abstract::In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4018-8

    authors: Seet EL,Yee JK,Jellyman JK,Han G,Ross MG,Desai M

    更新日期:2015-06-01 00:00:00

  • Quantification, characterization and fatty acid composition of lysophosphatidic acid in different rat tissues.

    abstract::The amount and composition of lysophosphatidate present in different rat tissues have been estimated by an internal standard method in which a synthetic unnatural isomer (1-heptadecanoyl-rac-glycerol-3-phosphate) was added to the total lipid extracts, and the fatty acid composition of purified lysophosphatidate was de...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535172

    authors: Das AK,Hajra AK

    更新日期:1989-04-01 00:00:00

  • Derivatization of keto fatty acids, X: Synthesis of thiazanones.

    abstract::The synthesis of alkyl chain-substituted thiazanones from oxo fatty esters and a long chain aldehyde is reported. Four oxo compounds-methyl 10-oxoundecanoate, methyl 9-oxooctadecanoate, methyl 9,10-dioxooctadecanoate and octadecanal-were allowed to react with β-mercaptopropionic acid in the presence of ammonium carbon...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537284

    authors: Khan A,Husain SR,Ahmad F,Siddiqui MS,Pimlott W

    更新日期:1987-08-01 00:00:00

  • Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress-induced gastric erosions.

    abstract::The purpose of this study was to examine the influence of long-term feeding of dietary fat rich in either n-3 or n-6 fatty acids on the availability of arachidonic acid (20:4n-6) in major phospholipids of gastric mucosa in rats. Three groups of male Wistar rats were fed either a standard diet, a cod liver oil-enriched...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0562-6

    authors: Olafsson SO,Hallgrimsson J,Gudbjarnason S

    更新日期:2000-06-01 00:00:00

  • Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp.

    abstract::Schizochytrium sp. is an algae-like microorganism utilized for commercial production of docosahexaenoic acid (DHA)-rich oil and dried microalgae for use as a source of DHA in foods, feeds, and nutritional supplements. Electron microscopic analysis of whole cells of Schizochytrium sp. employing sample preparation by hi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0655-2

    authors: Ashford A,Barclay WR,Weaver CA,Giddings TH,Zeller S

    更新日期:2000-12-01 00:00:00

  • Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture.

    abstract::The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0454-9

    authors: Xu X,Wang Y,Constantinou AI,Stacewicz-Sapuntzakis M,Bowen PE,van Breemen RB

    更新日期:1999-10-01 00:00:00

  • Increased Serum Level of Cyclopropaneoctanoic Acid 2-Hexyl in Patients with Hypertriglyceridemia-Related Disorders.

    abstract::We recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (b...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-016-4141-1

    authors: Mika A,Stepnowski P,Chmielewski M,Malgorzewicz S,Kaska L,Proczko M,Ratnicki-Sklucki K,Sledzinski M,Sledzinski T

    更新日期:2016-07-01 00:00:00

  • High-Fat Diet from Weaning until Early Adulthood Impairs T Cell Development in the Thymus.

    abstract::The growing prevalence of childhood obesity has become a serious health problem over the past few decades. Although the immune system is greatly affected by childhood obesity, whether obesity influences the T cell development in the thymus is poorly understood. In this study, we used a high-fat diet (HFD)-induced obes...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12193

    authors: Li H,Wetchapinant C,Zhang L,Wu K

    更新日期:2020-01-01 00:00:00

  • Sterol ester hydrolase in Fusarium oxysporum.

    abstract::Two electrophoretically different forms of sterol ester hydrolase (EC 3.1.1.13) were obtained from the cytoplasmic extract of the mycelia of Fusarium oxysporum. The entities, estimated at 60,000 (I) and 15,000 (II) molecular weights, were obtained in Sephadex G100 column chromatography of the ammonium sulfate precipit...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535686

    authors: Madhosingh C,Orr W

    更新日期:1981-02-01 00:00:00

  • Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro.

    abstract::The lipid quality of ruminant products is largely determined by the extent of rumen microbial biohydrogenation (BH) of polyunsaturated fatty acids (FAs) and the substances formed thereby. In vitro batch incubations with mixed rumen bacteria were tracked over 24 h to characterize the profiles and kinetics of the BH pro...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3032-x

    authors: Jouany JP,Lassalas B,Doreau M,Glasser F

    更新日期:2007-04-01 00:00:00

  • Modification of odd-chain length unsaturated fatty acids by hepatocytes of rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil.

    abstract::Hepatocytes isolated from rainbow trout fed on diets containing either fish oil or olive oil were incubated with individual odd-chain length unsaturated fatty acids (19:1n-9, 19:2n-6, 19:3n-3, 21:2n-6, 21:3n-6, 21:4n-6, 21:3n-3, and 21:5n-3) to examine whether these fatty acids were substrates for modification by desa...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-997-0078-0

    authors: Rodríguez C,Henderson RJ,Porter AE,Dick JR

    更新日期:1997-06-01 00:00:00

  • Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism.

    abstract::There is convincing evidence that normal cultured human keratinocytes possess a 15-lipoxygenase activity which, however, does not appear to manifest itself without cell membrane damage. When "activated", this enzyme transforms arachidonic acid into 15-hydroxyeicosatetraenoic acid (15-HETE), and linoleic acid into 13-h...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536012

    authors: Green FA

    更新日期:1990-10-01 00:00:00

  • Effects of ethionine and phenobarbital on the phosphatidylcholines of rat liver.

    abstract::The diglyceride species of phosphatidylcholines from livers of male rats after treatment of the animals with ethionine (1 mg/g divided among 4 doses 2 hr apart), phenobarbital (80 mg/kg each day for 3 days), or a combination of the two drugs were determined using gas chromatography. Ethionine treatment greatly elevate...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533307

    authors: Dyer RA,Klopfenstein WE

    更新日期:1977-11-01 00:00:00

  • The Hordaland Homocysteine Studies.

    abstract::The Hordaland Homocysteine Study is a population-based screening of total plasma homocysteine (tHcy) in approximately 18,000 men and women aged 40-67 yr that took place in 1992-1993 in the county of Hordaland in Western Norway. In this cohort, tHcy was associated with several physiologic and life-style factors, includ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0679-7

    authors: Ueland PM,Nygård O,Vollset SE,Refsum H

    更新日期:2001-01-01 00:00:00

  • Changes in the cholesterol and phospholipid content of mouse spleen after Raucscher leukemia virus infection.

    abstract::The effect of Rauscher Leukemia Virus (MuLV-R) infection on the lipid composition of mouse spleen from BALB/c mice was investigated. Drastic changes in the lipid composition of the spleen as a result of tumor growth induced by the virus could be demonstrated at 21 days after infection. The molar ratio of cholesterol t...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533406

    authors: Montfoort A,Boere WA,Griensven LJLDV

    更新日期:1976-11-01 00:00:00

  • Intestinal absorption of ester and ether glycerophospholipids in guinea pig. Role of a phospholipase A2 from brush border membrane.

    abstract::In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534872

    authors: Diagne A,Mitjavila S,Fauvel J,Chap H,Douste-Blazy L

    更新日期:1987-01-01 00:00:00

  • Activation of the phospholipase A1 activity of lipoprotein lipase by apoprotein C-II.

    abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02540967

    authors: Stocks J,Galton DJ

    更新日期:1980-03-01 00:00:00

  • Effect of SMP-500, a novel ACAT inhibitor, on hepatic cholesterol disposition in rats.

    abstract::The effects of SMP-500, a novel ACAT inhibitor, on serum lipid levels, hepatic lipid secretion rate, and hepatic lipid disposition in rats were studied to clarify its lipid-lowering action. SMP-500 reduced the serum cholesterol level in a dose-dependent manner in rats fed a hypercholesterolemic diet. SMP-500 also redu...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s1145-002-0907-1

    authors: Ioriya K,Nishimura T,Ohashi N

    更新日期:2002-04-01 00:00:00

  • Human platelets release a paf-acether: acetylhydrolase similar to that in plasma.

    abstract::Intact washed human platelets aggregated in response to paf-acether (paf) and did not metabolize [3H]paf at concentrations up to 10 nM. However, when platelets were lysed by exposure to pH 9.5, resulting in 37.5 +/- 2.5% (mean +/- SD, n = 3) lactic dehydrogenase (LDH) release, 20.5 +/- 5.7% of the radioactivity was de...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536639

    authors: Korth R,Bidault J,Palmantier R,Benveniste J,Ninio E

    更新日期:1993-03-01 00:00:00

  • Identification of a novel all-cis-5,9,12-heptadecatrienoic acid in the cellular slime mold Polysphondylium pallidum.

    abstract::The all-cis-5,9,12-heptadecatrienoic acid was identified in the cellular slime mold Polysphondylium pallidum. The structural elucidation was accomplished by capillary gas chromatography, argentation thin-layer chromatography, and gas chromatography/mass spectrometry. This fatty acid has not been reported previously. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522934

    authors: Saito T,Ochiai H

    更新日期:1996-04-01 00:00:00

  • The optical rotation of a major component of plant cutin.

    abstract::The major component of cutin from the fruit of both tomato and papaya, dihydroxypalmitate, is shown to have plain positive rotation and is, therefore, assigned L configuration in analogy to other known hydroxy fatty acids. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533487

    authors: Espelie KE,Kolattukudy PE

    更新日期:1978-11-01 00:00:00

  • Capillary gas chromatography and tandem mass spectrometry of paf-acether and analogs: absence of 1-O-alkyl-2-propionyl-sn-glycero-3-phosphocholine in human polymorphonuclear neutrophils.

    abstract::Fast atom bombardment-tandem mass spectrometry was used to identify molecular species of paf-acether (paf) produced by human polymorphonuclear neutrophils. Using this biological material, normal phase high performance liquid chromatography was necessary prior to the fast atom bombardment-tandem mass spectrometry step....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535248

    authors: Bossant MJ,Farinotti R,De Maack F,Mahuzier G,Benveniste J,Ninio E

    更新日期:1989-02-01 00:00:00

  • The effects of a dietary oxidized oil on lipid metabolism in rats.

    abstract::This study was carried out to investigate the effects of a dietary oxidized oil on lipid metabolism in rats, particularly the desaturation of fatty acids. Two groups of rats were fed initially for a period of 35 d diets containing 10% of either fresh oil or thermally treated oil (150 degrees C, 6 d). The dietary fats ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0418-0

    authors: Eder K

    更新日期:1999-07-01 00:00:00

  • Determination of the specific positions ofcis andtrans double bonds in polyenes.

    abstract::A method is described for the determination of the positions and geometric configurations of double bonds in polyunsaturated fatty acids. The procedure consists of three steps: 1) Partial reduction of the double bonds with hydrazine under conditions which give high yields of monoenes. 2) Isolation of thecis- and thetr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532998

    authors: Privett OS,Nickell EC

    更新日期:1966-03-01 00:00:00